Highlights of the evidence of benefit for women aged 40-49 years from the 14-year follow-up of the Breast Cancer Detection Demonstration Project.


:Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size, and the length and adequacy of follow-up. For women 40-49 years of age at entry the first randomized breast cancer screening trial, the Health Insurance Program of Greater New York (HIP), showed a statistically significant decrease of 24% in breast cancer mortality at 18 years of follow-up, virtually the same as the 23% decrease seen in women 50-59 years of age. At 10-12 years of follow-up, five of seven randomized trials have shown nonstatistical decreases in breast cancer mortality. No trials with fewer than 8 years of follow-up have shown a decrease in mortality for women 40-49 years of age; whereas seven trials have shown a decrease for women older than 50 years of age. The largest study on the screening of women aged 40-49 (93,471) was the Breast Cancer Detection Demonstration Program (BCDDP). This demonstration program was not a randomized trial but has yielded indirect supportive evidence for the screening of women aged 40-49, by comparing age group results. Three highlights of these studies are presented: (1) Mammography in the BCDDP (1970s) was improved greatly compared to that in the HIP study (1960s). Mammography detected 40% of the cancers in women 40-49 years of age in the HIP compared to 90% in the BCDDP. In women 50-59 years of age, mammography detected 60% of cancers in the HIP but 92% in the BCDDP. (2) Using annual two-view mammography plus clinical breast examination after the first screen of women 45 years of age and older, subsequent detection rates were virtually the same for all age groups. The number of women screened annually yields slightly more than two breast cancers per 1000 women, regardless of age group. (3) Similar types, sizes, stage distributions, and survival and case fatality rates were demonstrated in women aged 40-49, 50-59 and 60-69 years.






Smart CR




Has Abstract


1994-07-01 00:00:00




1 Suppl










  • Long-term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma.

    abstract:BACKGROUND:The authors report the long-term treatment results for advanced stage base of tongue (BOT) and tonsillar fossa (TF) carcinomas treated with surgery and postoperative radiation therapy (RT) at Memorial Sloan-Kettering Cancer Center. METHODS:Between 1973 and 1986, 51 patients with squamous cell carcinoma of t...


    pub_type: 杂志文章


    authors: Zelefsky MJ,Harrison LB,Armstrong JG

    更新日期:1992-11-15 00:00:00

  • Malignant lymphoepithelial lesion of the parotid gland: poorly differentiated squamous cell carcinoma with lymphoid stroma.

    abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...


    pub_type: 杂志文章


    authors: Redondo C,Garcia A,Vazquez F

    更新日期:1981-07-15 00:00:00

  • Paclitaxel, carboplatin, and long-term continuous infusion of 5-fluorouracil in the treatment of advanced squamous and other selected carcinomas: results of a Phase II trial.

    abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility, toxicity, and efficacy of the combination of paclitaxel, carboplatin, and long-term continuous infusion 5-fluorouracil (5-FU) in the treatment of advanced squamous carcinomas of various primary sites. METHODS:Patients were eligible for this trial if...


    pub_type: 临床试验,杂志文章


    authors: Hainsworth JD,Burris HA 3rd,Meluch AA,Baker MN,Morrissey LH,Greco FA

    更新日期:2001-08-01 00:00:00

  • Resection of brain metastases from colorectal carcinoma in 73 patients.

    abstract:BACKGROUND:At the time of diagnosis of colorectal carcinoma, 2-3% of patients are likely to be harboring brain metastases, and another 10% of patients will develop brain lesions during the course of their disease. The purpose of this study was to examine the clinical course of a group of patients with metastatic brain ...


    pub_type: 杂志文章


    authors: Wroński M,Arbit E

    更新日期:1999-04-15 00:00:00

  • Common expression of parathyroid hormone-related protein and no correlation of calcium level in renal cell carcinomas.

    abstract:BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal...


    pub_type: 杂志文章


    authors: Gotoh A,Kitazawa S,Mizuno Y,Takenaka A,Arakawa S,Matsumoto O,Kitazawa R,Fujimori T,Maeda S,Kamidono S

    更新日期:1993-05-01 00:00:00

  • Prognostic value of CD44 isoform expression in thymic epithelial neoplasms.

    abstract:BACKGROUND:Many histologic classifications of thymic epithelial tumors have been reported to date, but to the authors' knowledge, none of them closely reflect the clinical behavior or prognosis of the tumor. Therefore, it is necessary to establish a biologic marker for thymic epithelial tumors. Variants of CD44 may be ...


    pub_type: 杂志文章


    authors: Sonobe S,Miyamoto H,Nobukawa B,Izumi H,Futagawa T,Ishikawa N,Yamazaki A,Uekusa T,Abe H,Suda K

    更新日期:2005-05-15 00:00:00

  • Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas.

    abstract:BACKGROUND:Patients with advanced soft tissue sarcomas (STS) have limited therapeutic options. Sorafenib (BAY 43-9006) is a multitargeted tyrosine kinase inhibitor of raf, vascular endothelial growth factor receptors 1 (VEGFR1) through 3, platelet-derived growth factor B, fms-like tyrosine kinase 3, and c-kit, and some...


    pub_type: 杂志文章,多中心研究


    authors: von Mehren M,Rankin C,Goldblum JR,Demetri GD,Bramwell V,Ryan CW,Borden E

    更新日期:2012-02-01 00:00:00

  • Humoral immune response in melanoma and glioma patients: a solubilized melanoma-membrane component as a tool for detecting circulating antibodies.

    abstract::In search of tumor-associated components in human melanomas and gliomas, plasma membranes were isolated from these tumors and compared morphologically, biochemically and immunologically with those from normal human brain. The preparations exhibited a comparable ultrastructure of empty vesicles of various form and size...


    pub_type: 杂志文章


    authors: Birkmayer GD

    更新日期:1981-12-01 00:00:00

  • Ascertainment of postprostatectomy radiotherapy for prostate cancer in the Surveillance, Epidemiology, and End Results database.

    abstract:BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data are frequently used to examine receipt of adjuvant radiotherapy (RT), but to the authors' knowledge the accuracy of data regarding second-course treatments is unknown. METHODS:Using SEER-Medicare-linked data, the authors identified a cohort of men who ...


    pub_type: 杂志文章


    authors: Wang K,Sheets NC,Basak R,Chen RC

    更新日期:2016-10-01 00:00:00

  • The use of prognostic factors in clinical trials.

    abstract::Numerous examples exist of prognostic factors that have been conclusively established and that can segregate the target patient population into subgroups with vastly different outcomes. At the same time, we can expect, in the majority of trials being conducted, that if a new treatment turns out to be successful, it ge...


    pub_type: 杂志文章


    authors: Sather HN

    更新日期:1986-07-15 00:00:00

  • Pathologic findings from the National Surgical Adjuvant Breast Project. VIII. Relationship of chemotherapeutic responsiveness to tumor differentiation.

    abstract::The possible influence of histologic grade, necrosis and size of invasive breast cancers on the five year survival rate of women treated in NSABP clinical trials with regimens of L-PAM (P) and L-PAM + 5-FU (PF) and for four years in those receiving L-PAM + 5-FU + methotrexate (PMF) was investigated. Generally, all reg...


    pub_type: 杂志文章


    authors: Fisher ER,Redmond C,Fisher B

    更新日期:1983-01-15 00:00:00

  • Nonbleeding adenomas: Evidence of systematic false-negative fecal immunochemical test results and their implications for screening effectiveness-A modeling study.

    abstract:BACKGROUND:If some adenomas do not bleed over several years, they will cause systematic false-negative fecal immunochemical test (FIT) results. The long-term effectiveness of FIT screening has been estimated without accounting for such systematic false-negativity. There are now data with which to evaluate this issue. ...


    pub_type: 杂志文章


    authors: van der Meulen MP,Lansdorp-Vogelaar I,van Heijningen EM,Kuipers EJ,van Ballegooijen M

    更新日期:2016-06-01 00:00:00

  • Prognostic variables in patients with hepatic metastases from colorectal cancer. Importance of medical assessment of liver involvement.

    abstract::Variation in response rates to chemotherapy and survival in patients with hepatic metastases from colorectal carcinoma may be due to patient selection factors. The prognostic importance of 13 factors were analyzed in 112 patients with only hepatic metastases, who were eligible for hepatic artery infusional chemotherap...


    pub_type: 杂志文章


    authors: Kemeny N,Niedzwiecki D,Shurgot B,Oderman P

    更新日期:1989-02-15 00:00:00

  • Use of adjuvant radiotherapy at hospitals with and without on-site radiation services.

    abstract:BACKGROUND:In many areas of health care, whether patients receive specific medical interventions often is influenced heavily by the local availability of resources for delivering those services. However, relations between resource availability and utilization are relatively unexplored in cancer care, including perioper...


    pub_type: 杂志文章


    authors: Wong SL,Wei Y,Birkmeyer JD

    更新日期:2007-02-15 00:00:00

  • Smoking status and survival in the national comprehensive cancer network non-small cell lung cancer cohort.

    abstract:BACKGROUND:The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non-small cell lung cancer (NSCLC). METHODS:The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, form...


    pub_type: 杂志文章


    authors: Ferketich AK,Niland JC,Mamet R,Zornosa C,D'Amico TA,Ettinger DS,Kalemkerian GP,Pisters KM,Reid ME,Otterson GA

    更新日期:2013-02-15 00:00:00

  • Brain metastasis from renal cell carcinoma: presentation, recurrence, and survival.

    abstract:BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...


    pub_type: 杂志文章


    authors: Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

    更新日期:2008-10-01 00:00:00

  • Prostate cancer mortality and metastasis under different biopsy frequencies in North American active surveillance cohorts.

    abstract:BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...


    pub_type: 杂志文章


    authors: Lange JM,Laviana AA,Penson DF,Lin DW,Bill-Axelson A,Carlsson SV,Newcomb LF,Trock BJ,Carter HB,Carroll PR,Cooperberg MR,Cowan JE,Klotz LH,Etzioni RB

    更新日期:2020-02-01 00:00:00

  • Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

    abstract:BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...


    pub_type: 杂志文章


    authors: Cassier PA,Gelderblom H,Stacchiotti S,Thomas D,Maki RG,Kroep JR,van der Graaf WT,Italiano A,Seddon B,Dômont J,Bompas E,Wagner AJ,Blay JY

    更新日期:2012-03-15 00:00:00

  • Breast cancer in women of Japanese and Caucasian ancestry in Hawaii.

    abstract::A pathology review of breast cancers in Japanese and Caucasian women indicates more numerous in situ carcinomas in the Japanese. Carcinomas with uniform nuclei were also more numerous among Japanese. Japanese women showed more extensive lymphocytic infiltrates adjacent to their tumors than did Caucasian women, and als...


    pub_type: 杂志文章


    authors: Stemmermann GN,Catts A,Fukunaga FH,Horie A,Nomura AM

    更新日期:1985-07-01 00:00:00

  • Recurrent meningioma.

    abstract::Single meningiomas are histologically classified as benign tumors, but clearly malignant types have been encountered. The standard mode of management is total macroscopic removal with excision of the dural attachment and abnormal bone, if there is any. Despite this aggressive surgery, recurrence rates of approximately...


    pub_type: 杂志文章,评审


    authors: Boylan SE,McCunniff AJ

    更新日期:1988-04-01 00:00:00

  • Familial ovarian cancer. A report of 658 families from the Gilda Radner Familial Ovarian Cancer Registry 1981-1991.

    abstract:BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...


    pub_type: 杂志文章


    authors: Piver MS,Baker TR,Jishi MF,Sandecki AM,Tsukada Y,Natarajan N,Mettlin CJ,Blake CA

    更新日期:1993-01-15 00:00:00

  • Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas.

    abstract::Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...


    pub_type: 杂志文章


    authors: Gray SR,Cornog JL Jr,Seo IS

    更新日期:1976-09-01 00:00:00

  • Intrapulmonary presentation of extraskeletal myxoid chondrosarcoma of the extremity. Report of two cases.

    abstract::Two cases of extraskeletal myxoid chondrosarcoma are reported. The patients presented with metastasis to the lung, 10 years and 2 years, respectively, prior to discovery of the primary neoplasms in the soft tissues of the lower extremities. ...


    pub_type: 杂志文章


    authors: D'Ambrosio FG,Shiu MH,Brennan MF

    更新日期:1986-09-01 00:00:00

  • A case of multiple myeloma with two subclones producing separately kappa and defective gamma chains.

    abstract::A case of multiple myeloma is described that contained two morphologically identical but immunologically diverse subpopulations. One of the subclones produced only kappa chains, whereas the other contained only gamma chains. Additional immunohistologic investigations revealed production by one of the subpopulations of...


    pub_type: 杂志文章


    authors: Metz K,Leder LD

    更新日期:1985-09-15 00:00:00

  • A phase I report of paclitaxel dose escalation combined with a fixed dose of carboplatin in the treatment of head and neck carcinoma.

    abstract:BACKGROUND:Standard therapy for advanced head and neck carcinoma is surgery and radiation, and the subsequent 5-year survival with this treatment has been less than 50%. New combined modality treatment strategies are being tested to improve survival. New chemotherapy combinations are being developed and administered si...


    pub_type: 临床试验,杂志文章


    authors: Dunphy FR,Boyd JH,Kim HJ,Dunphy CH,Harrison BR,Dunleavy TL,Rodriguez JJ,McDonough EM,Minster JR,Hilton JG

    更新日期:1997-05-15 00:00:00

  • Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience.

    abstract:BACKGROUND:In 1991, the Italian Association for Pediatric Hematology-Oncology and the National Council of Research (CNR) initiated an Italian Cooperative Study (SE 91-CNR Protocol) with the main objective of improving the overall survival (SUR) and the event free survival (EFS) of children and young adults with localiz...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Rosito P,Mancini AF,Rondelli R,Abate ME,Pession A,Bedei L,Bacci G,Picci P,Mercuri M,Ruggieri P,Frezza G,Campanacci M,Paolucci G

    更新日期:1999-08-01 00:00:00

  • Validation of a multidimensional evaluation scale for use in elderly cancer patients.

    abstract:BACKGROUND:Although aging is one of the most important risk factors for cancer, elderly patients tend to be excluded from cancer clinical trials, only on the basis of chronologic age. Performance Status (PS) has been used widely to select adult patients for entry into clinical trials, but it does not include a comprehe...


    pub_type: 杂志文章


    authors: Monfardini S,Ferrucci L,Fratino L,del Lungo I,Serraino D,Zagonel V

    更新日期:1996-01-15 00:00:00

  • Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.

    abstract:BACKGROUND:Multiple cell-signaling ligands and receptors-including vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), endothelial growth factor (EGF), v-akt murine thymoma viral oncogene homolog (AKT), platelet-derived growth factor (PDGF), mitogen-activated protein kinase (MAPK), and 70-kilod...


    pub_type: 杂志文章


    authors: Abdeen A,Chou AJ,Healey JH,Khanna C,Osborne TS,Hewitt SM,Kim M,Wang D,Moody K,Gorlick R

    更新日期:2009-11-15 00:00:00

  • Risk factors for bilateral testicular germ cell tumors. Does heredity play a role?

    abstract::Twenty-three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on th...


    pub_type: 杂志文章,评审


    authors: Kratzik C,Aiginger P,Kuber W,Riccabona M,Kührer I,Joos H,Frick J,Amann G,Mayr W

    更新日期:1991-08-15 00:00:00

  • Observations on growth rate of breast carcinomas and its possible implications for lead time.

    abstract::Doubling times were estimated for 15 breast carcinomas in 13 patients, and were found to be between 42 and 397 days with the average at 211 days. The mean lead time at mean growth rate from the average size of 44 preclinical to the average size of 118 clinical tumors was estimated to be 3 years. This period may be con...


    pub_type: 杂志文章


    authors: Lundgren B

    更新日期:1977-10-01 00:00:00