Abstract:
:Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose and more frequent administration of MTX-CF. In view of the transient nature of the abnormalities, a biochemical cause is implicated, and the mechanisms by which it may occur are discussed.
journal_name
Cancerjournal_title
Cancerauthors
Jaffe N,Takaue Y,Anzai T,Robertson Rdoi
10.1002/1097-0142(19850915)56:6<1356::aid-cncr2820subject
Has Abstractpub_date
1985-09-15 00:00:00pages
1356-60issue
6eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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