Malignant "Triton" tumors. Natural history and immunohistochemistry of nine new cases with literature review.


:Malignant schwannomas with rhabdomyoblastic differentiation have been termed malignant "Triton" tumors (MTT). To define the natural history of MTT, we have analyzed our experience (9 cases, the largest series reported) in combination with the 27 previously described in the literature (total 36 cases). This study was initiated due to the unusual presentation of MTT as a polypoid esophageal mass. Rhabdomyoblastic differentiation in these tumors was confirmed using myoglobin immunohistochemistry. Two groups of patients were identified: those with Von Recklinghausen's Neurofibromatosis (Group I, VRN cases); and those without (Group II, sporadic, non-VRN cases). Group I patients accounted for over 70% of cases and displayed a marked male predominance, young age, and common head and neck presentation. By contrast, Group II patients were older, had a female predominance, and tumors frequently located on the trunk. Both groups fared equally poorly: local recurrence was common and the 5-year survival rate for all cases was 12%. Our data support the view that the natural history of MTT, whether in VRN patients or not, is much more aggressive than sporadic malignant schwannoma and similar to VRN sarcomas in general. This poor outlook could not be attributed to site; rather, it appeared to reflect the high frequency of Grade III histology in this disease.






Brooks JS,Freeman M,Enterline HT




Has Abstract


1985-06-01 00:00:00














  • Randomized study of 5-FU and CCNU in pancreatic cancer: report of the Veterans Administration Surgical Adjuvant Cancer Chemotherapy Study Group.

    abstract::Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Bot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frey C,Twomey P,Keehn R,Elliott D,Higgins G

    更新日期:1981-01-01 00:00:00

  • The diagnostic value of the hemoccult as a screening test in patients taking anticoagulants.

    abstract::The value of a 3-day Hemoccult II test in the diagnosis of colorectal disease in patients receiving anticoagulant therapy was studied. The influence of rehydration and nonrehydration of the slide was investigated, as well as the reproducibility of positive tests. Eight hundred forty-nine patients on anticoagulant ther...


    pub_type: 杂志文章


    authors: Kewenter J,Svanvik J,Svensson C,Wållgren K

    更新日期:1984-12-15 00:00:00

  • B-cell lymphoma in severe combined immunodeficiency not associated with the Epstein-Barr virus.

    abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...


    pub_type: 杂志文章


    authors: Garcia CR,Brown NA,Schreck R,Stiehm ER,Hudnall SD

    更新日期:1987-12-15 00:00:00

  • Automated tobacco assessment and cessation support for cancer patients.

    abstract:BACKGROUND:Tobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients. METHODS:A structured tobacco assessment was incorporated into the electronic heal...


    pub_type: 杂志文章


    authors: Warren GW,Marshall JR,Cummings KM,Zevon MA,Reed R,Hysert P,Mahoney MC,Hyland AJ,Nwogu C,Demmy T,Dexter E,Kelly M,O'Connor RJ,Houstin T,Jenkins D,Germain P,Singh AK,Epstein J,Dobson Amato KA,Reid ME

    更新日期:2014-02-15 00:00:00

  • The prognostic significance of nuclear DNA content in malignant epithelial tumors of the ovary.

    abstract::Recent studies have indicated that the nuclear DNA content of certain malignant neoplasms can be used as an adjunct in predicting their biologic behavior. The DNA content of 99 ovarian carcinomas was determined by flow cytometric analysis of nuclei obtained from paraffin-embedded tissue. Of the 99 tumors, 51 were dipl...


    pub_type: 杂志文章


    authors: Brescia RJ,Barakat RA,Beller U,Frederickson G,Suhrland MJ,Dubin N,Demopoulos RI

    更新日期:1990-01-01 00:00:00

  • Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas.

    abstract:BACKGROUND:Despite optimal therapy with surgery and radiotherapy, the prognosis of patients with glioblastomas remains poor. Stereotactic brachytherapy involves the accurate placement of radioactive isotopes within brain tumors, significantly increasing the dose of radiation that can be delivered to the tumor bed witho...


    pub_type: 临床试验,杂志文章


    authors: Wen PY,Alexander E 3rd,Black PM,Fine HA,Riese N,Levin JM,Coleman CN,Loeffler JS

    更新日期:1994-06-15 00:00:00

  • Spinal epidural tumor in patients with prostate cancer. Clinical and radiographic predictors of response to radiation therapy.

    abstract::The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...


    pub_type: 杂志文章


    authors: Zelefsky MJ,Scher HI,Krol G,Portenoy RK,Leibel SA,Fuks ZY

    更新日期:1992-11-01 00:00:00

  • The size of breast masses at presentation. The impact of prior medical training.

    abstract::Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...


    pub_type: 杂志文章


    authors: Buttlar CA,Templeton AC

    更新日期:1983-05-01 00:00:00

  • Earlier diagnosis of second primary melanoma confirms the benefits of patient education and routine postoperative follow-up.

    abstract:BACKGROUND:Rising health care costs have caused providers to question the benefit of regular follow-up after treatment for patients with early stage cutaneous melanoma. The authors hypothesized that routine reassessment and careful education of these patients would facilitate earlier diagnosis of a subsequent second pr...


    pub_type: 杂志文章


    authors: DiFronzo LA,Wanek LA,Morton DL

    更新日期:2001-04-15 00:00:00

  • Management and results of endometrial carcinoma treated at Instituto Português de Oncologia de Francisco Gentil.

    abstract::The experience of 260 patients with endometrial carcinoma was reviewed. The influence of factors such as age, stage of disease, grade and degree of myometrial penetration on the survival was presented, showing that survival decreases in elderly patients, in patients with advanced stage of disease, when the tumor is un...


    pub_type: 杂志文章


    authors: Tavares MA,Patricio MB,Vilhena M,Da Silva JN

    更新日期:1977-02-01 00:00:00

  • Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.

    abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...


    pub_type: 杂志文章,评审


    authors: Epstein AL,Levy R,Kim H,Henle W,Henle G,Kaplan HS

    更新日期:1978-11-01 00:00:00

  • Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer: findings from the bolus, infusional, or capecitabine with camptostar-celecoxib study.

    abstract:BACKGROUND:Irinotecan-based chemotherapy regimens are 1 option for treatment of metastatic colorectal cancer (mCRC). The authors report the safety and efficacy of such regimens in elderly patients using a large phase III trial (bolus, infusional, or capecitabine with camptostar-celecoxib [BICC-C]) cohort. METHODS:In p...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jackson NA,Barrueco J,Soufi-Mahjoubi R,Marshall J,Mitchell E,Zhang X,Meyerhardt J

    更新日期:2009-06-15 00:00:00

  • Influence of the time between surgery and radiotherapy on local recurrence in patients with lymph node-positive, early-stage, invasive breast carcinoma undergoing breast-conserving surgery: results of the French Adjuvant Study Group.

    abstract:BACKGROUND:Radiotherapy (RT) after breast-conserving surgery (BCS) has produced significant reductions in ipsilateral breast carcinoma (BC) recurrence. It was shown previously that a delay in the initiation of RT resulted in a higher local recurrence (LR) rate. In the current retrospective analysis, the authors investi...


    pub_type: 杂志文章


    authors: Benchalal M,Le Prisé E,de Lafontan B,Berton-Rigaud D,Belkacemi Y,Romestaing P,Peignaux K,Courdi A,Monnier A,Montcuquet P,Goudier MJ,Marchal C,Chollet P,Abadie-Lacourtoisie S,Datchary J,Veyret C,Kerbrat P

    更新日期:2005-07-15 00:00:00

  • Hepatoid adenocarcinomas of the stomach. An analysis of seven cases.

    abstract::Hepatoid adenocarcinomas of the stomach are gastric carcinomas with both adenocarcinomatous and hepatocellular differentiations. They usually produce large amounts of alpha-fetoprotein (AFP) with a Concanavalin A-binding property of hepatic type. In this study, these carcinomas occurred in older persons, with the antr...


    pub_type: 杂志文章


    authors: Ishikura H,Kirimoto K,Shamoto M,Miyamoto Y,Yamagiwa H,Itoh T,Aizawa M

    更新日期:1986-07-01 00:00:00

  • Current role of gallium scan and magnetic resonance imaging in the management of mediastinal Hodgkin lymphoma.

    abstract:BACKGROUND:A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium-67 (67Ga) imagin...


    pub_type: 杂志文章


    authors: Gasparini MD,Balzarini L,Castellani MR,Tesoro Tess JD,Maffioli LS,Petrillo R,Ceglia E,Musumeci R,Buraggi GL

    更新日期:1993-07-15 00:00:00

  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...


    pub_type: 杂志文章


    authors: Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

    更新日期:2012-01-15 00:00:00

  • Gender and other survival predictors in patients with metastatic melanoma on Southwest Oncology Group trials.

    abstract:BACKGROUND:Some studies have suggested that women with metastatic malignant melanoma have a better survival rate than men. However, little is known about the effect of gender on survival in combination with other clinical variables and treatment variables. Thus, an analysis of 813 eligible patients from 15 consecutive ...


    pub_type: 杂志文章,meta分析,多中心研究


    authors: Unger JM,Flaherty LE,Liu PY,Albain KS,Sondak VK

    更新日期:2001-03-15 00:00:00

  • Multiple visceral and cutaneous granular cell tumors. Ultrastructural and immunocytochemical evidence of Schwann cell origin.

    abstract::Granular cell tumor of the stomach is rare and may occur in association with similar tumors in the skin. Two such tumors were found in association with cutaneous granular cell tumors in two black females. Infiltrating carcinoma of the stomach was suspected at surgery in one case. All of the lesions were typical granul...


    pub_type: 杂志文章


    authors: Seo IS,Azzarelli B,Warner TF,Goheen MP,Senteney GE

    更新日期:1984-05-15 00:00:00

  • Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma.

    abstract:BACKGROUND:Ribonucleotide reductase M1 (RRM1) is an important molecule in different types of cancer. The objective of this study was to evaluate the predictive roles of RRM1 in the survival of patients with resectable pancreatic adenocarcinoma who received treatment with gemcitabine or nongemcitabine adjuvant therapy. ...


    pub_type: 杂志文章


    authors: Xie H,Jiang W,Jiang J,Wang Y,Kim R,Liu X,Liu X

    更新日期:2013-01-01 00:00:00

  • A retrospective study of 370 borderline tumors of the ovary treated at the Norwegian Radium Hospital from 1970 to 1982. A review of clinicopathologic features and treatment modalities.

    abstract:METHODS:Three-hundred seventy patients with borderline tumors treated between 1970 and 1982 at the Norwegian Radium Hospital were analyzed retrospectively for clinicopathologic features, treatment, and survival characteristics. RESULTS:One hundred seventy-eight patients had mucinous tumors, 174 patients had serous tum...


    pub_type: 杂志文章


    authors: Kaern J,Tropé CG,Abeler VM

    更新日期:1993-03-01 00:00:00

  • Patient issues in breast reconstruction.

    abstract::Breast reconstruction is not a new idea. Techniques have been developing since the late 1800s. The state of the art is such that the knowledge of its availability and success has significant effect on the willingness of women to seek earlier diagnosis and treatment. However, reconstruction is not for everyone. This pa...


    pub_type: 杂志文章,评审


    authors: Brown HG

    更新日期:1991-09-01 00:00:00

  • A comparison of treatment outcomes for black patients and white patients with metastatic breast cancer. The Piedmont Oncology Association experience.

    abstract::Prior studies have shown that black patients with breast cancer have poorer survival times compared with white patients even when adjusted for stage. Seventy-four black patients treated on six Piedmont Oncology Association (POA) protocols were compared with 74 randomly selected white patients treated with the same pro...


    pub_type: 杂志文章


    authors: Kimmick G,Muss HB,Case LD,Stanley V

    更新日期:1991-06-01 00:00:00

  • Primary hepatic or hepatosplenic non-Hodgkin's lymphoma in children.

    abstract::Non-Hodgkin's lymphoma confined to the liver is unusual in adults and has not been reported in children. Two children with primary hepatic and one with hepatosplenic NHL are described. All three patients are males, and both tumors examined for cell surface markers were of B-cell origin. Two patients, treated with chem...


    pub_type: 杂志文章


    authors: Miller ST,Wollner N,Meyers PA,Exelby P,Jereb B,Miller DR

    更新日期:1983-12-15 00:00:00

  • Feasibility study of active immunotherapy in patients with solid tumors.

    abstract::Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...


    pub_type: 杂志文章


    authors: Gerner RE,Moore GE

    更新日期:1976-07-01 00:00:00

  • Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors.

    abstract:BACKGROUND:Response rates to second-line chemotherapy in recurrent high-grade glial tumors are low and new effective treatments are needed. The objective of this study was to evaluate response rates and tolerability of chemotherapy with bevacizumab and irinotecan in recurrent high-grade gliomas. METHODS:Twenty patient...


    pub_type: 杂志文章


    authors: Bokstein F,Shpigel S,Blumenthal DT

    更新日期:2008-05-15 00:00:00

  • Symptoms and rehabilitation needs of patients with early stage breast cancer during primary therapy.

    abstract::The treatment for women diagnosed with early breast cancer is complex, dynamic, and controversial. More choices are available for local control and indications for systemic adjuvant therapy have changed dramatically. Knowledge of predictable physical and psychological responses through the various phases of primary tr...


    pub_type: 杂志文章,评审


    authors: Knobf MT

    更新日期:1990-09-15 00:00:00

  • Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes.

    abstract:BACKGROUND:The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to i...


    pub_type: 杂志文章


    authors: Kim JH,Yoon HK,Sung KB,Ko GY,Gwon DI,Shin JH,Song HY

    更新日期:2008-10-01 00:00:00

  • Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region.

    abstract:BACKGROUND:Diencephalic syndrome (DS) is a complex of signs and symptoms related to hypothalamic dysfunction; its main features are emaciation, despite a normal or slightly diminished caloric intake, and an alert appearance. DS has been almost exclusively described in association with space-occupying lesions of the hyp...


    pub_type: 杂志文章


    authors: Perilongo G,Carollo C,Salviati L,Murgia A,Pillon M,Basso G,Gardiman M,Laverda A

    更新日期:1997-07-01 00:00:00

  • Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy.

    abstract::An analysis of patterns of relapse from complete remission in patients with non-Hodgkin's lymphoma treated with combination chemotherapy has demonstrated differences between histologic subgroups. Patients with diffuse histiocytic lymphoma who achieved a histologically proven complete remission after 6 months of treatm...


    pub_type: 杂志文章


    authors: Schein PS,Chabner BA,Canellos GP,Young RC,DeVita VT Jr

    更新日期:1975-02-01 00:00:00

  • Ureteral obstruction in patients with breast cancer.

    abstract::Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...


    pub_type: 杂志文章


    authors: Recloux P,Weiser M,Piccart M,Sculier JP

    更新日期:1988-05-01 00:00:00