Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation.

Abstract:

BACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree. METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenetics and flow results from 424 patients, before and after hematopoietic cell transplantation, and compared the prognostic impact of discordant and concordant results. RESULTS:Informative discordant results were observed in 22% of patients. Compared with patients who had double-negative test results, either positive result had a significant impact on overall survival and relapse-free survival. The hazard ratios with either positive cytogenetic results or positive MFC results pretransplantation were 3.1 (P = .009) and 2.5 (P = .0008), respectively, for reduced overall survival and 2.7 (P = .01) and 4.1 (P < .0001), respectively, for decreased recurrence-free survival. Similar findings were obtained post-transplantation. Molecular cytogenetics, ie, fluorescence in situ hybridization (FISH), added value to the evaluation of discordant cases. CONCLUSIONS:The detection of residual AML by either cytogenetics or flow cytometry in patients who underwent hematopoietic cell transplantation predicted early relapse and shortened survival.

journal_name

Cancer

journal_title

Cancer

authors

Fang M,Storer B,Wood B,Gyurkocza B,Sandmaier BM,Appelbaum FR

doi

10.1002/cncr.26539

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

2411-9

issue

9

eissn

0008-543X

issn

1097-0142

journal_volume

118

pub_type

杂志文章

相关文献

CANCER文献大全
  • Prognosis in Black children with neuroblastoma.

    abstract::Thirty white and 15 black children with neuroblastoma were compared with respect to survival. Patient age and tumor stage at diagnosis were similar in the two groups, as was duration of symptoms prior to diagnosis. There was no significant difference between the white and black children in regard to median duration of...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1151::aid-cncr282036

    authors: DiNicola W,Movassaghi N,Leikin S

    更新日期:1975-09-01 00:00:00

  • Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome.

    abstract:BACKGROUND:The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20431

    authors: Chang G,Orav EJ,McNamara T,Tong MY,Antin JH

    更新日期:2004-08-15 00:00:00

  • Basaloid squamous cell carcinoma of floor of mouth.

    abstract:BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820

    authors: Coppola D,Catalano E,Tang CK,Elfenbein IB,Harwick R,Mohr R

    更新日期:1993-10-15 00:00:00

  • Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder.

    abstract:BACKGROUND:Transitional cell carcinoma (TCC) of the bladder displays an unpredictable biologic behavior and the morphologic methods of grading tumor malignancy are often insufficient to predict the clinical outcome of patients with TCC of the bladder. Thus, the new indicator should reliably reflect prognosis. In this s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19961015)78:8<1762::aid-cn

    authors: Shiina H,Igawa M,Nagami H,Yagi H,Urakami S,Yoneda T,Shirakawa H,Ishibe T,Kawanishi M

    更新日期:1996-10-15 00:00:00

  • Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study.

    abstract::Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810201)47:3<470::aid-cncr28204

    authors: Askin FB,Land VJ,Sullivan MP,Ragab AH,Steuber CP,Dyment PG,Talbert J,Moore T

    更新日期:1981-02-01 00:00:00

  • Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcoma.

    abstract:BACKGROUND:There have been several recent reports that Wilms tumor gene (WT1) mRNA is overexpressed in many types of neoplasms, and those results suggested that WT1 has oncogenic properties. The objective of the current study was to evaluate the prognostic significance of WT1 mRNA expression in patients with soft tissu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21861

    authors: Sotobori T,Ueda T,Oji Y,Naka N,Araki N,Myoui A,Sugiyama H,Yoshikawa H

    更新日期:2006-05-15 00:00:00

  • Social needs and health-related quality of life among African American cancer survivors: Results from the Detroit Research on Cancer Survivors study.

    abstract:BACKGROUND:Social needs may affect cancer survivors' health-related quality of life (HRQOL) above and beyond sociodemographic and cancer-related factors. The purpose of this study was to estimate associations between social needs and HRQOL. METHODS:Results included data from 1754 participants in the Detroit Research o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33286

    authors: Hastert TA,McDougall JA,Strayhorn SM,Nair M,Beebe-Dimmer JL,Schwartz AG

    更新日期:2021-02-01 00:00:00

  • Use of carcinoembryonic antigen in small cell lung cancer. Prognostic value and relation to the clinical course 1.

    abstract::Carcinoembryonic antigen (CEA) was measured in 147 patients at diagnosis of small cell lung cancer; 17% of patients with limited disease and 51% with extensive disease had an abnormal CEA level (greater than 10 ng/ml). The median level was higher in extensive than in limited disease (11 ng/ml and 5.8 ng/ml, respective...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2047::aid-cncr282

    authors: Laberge F,Fritsche HA,Umsawasdi T,Carr DT,Welch S,Murphy WK,Chiuten DF,Dhingra HM,Farha P,Spitzer G

    更新日期:1987-06-15 00:00:00

  • Evaluation of cervical cancer by computed tomography: current status.

    abstract::In the evaluation of cervical cancer, computed tomography (CT) is used primarily to stage advanced tumors and evaluate for recurrence. Because of reports that CT imaging lacks sensitivity and specificity in the detection of primary tumors and metastatic lesions, its use in these applications has been limited, but rece...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11684

    authors: Pannu HK,Fishman EK

    更新日期:2003-11-01 00:00:00

  • Deceptive bizarre stromal cells in polyps and ulcers of the gastrointestinal tract.

    abstract::The clinical and pathologic features of 33 pseudomalignant lesions of the gastrointestinal tract with bizarre stromal cells are reported. Deceptive histologic changes were identified in ulcers of seven patients and in inflammatory polyps of 26. A misdiagnosis of malignant neoplasm was made in six of the 33 patients (t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910415)67:8<2111::aid-cncr2820

    authors: Shekitka KM,Helwig EB

    更新日期:1991-04-15 00:00:00

  • Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes.

    abstract:BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33105

    authors: Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

    更新日期:2020-11-01 00:00:00

  • Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer.

    abstract:BACKGROUND:The purpose of this study was to characterize insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) expression in patients with nonsmall cell lung cancer (NSCLC). METHODS:A total of 459 patients who underwent curative resection of NSCLC were studied (median follow-up duration, 4.01 years)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26492

    authors: Kim JS,Kim ES,Liu D,Lee JJ,Solis L,Behrens C,Lippman SM,Hong WK,Wistuba II,Lee HY

    更新日期:2012-05-01 00:00:00

  • Assessing the impact of patient navigation: prevention and early detection metrics.

    abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.26267

    authors: Battaglia TA,Burhansstipanov L,Murrell SS,Dwyer AJ,Caron SE,Prevention and Early Detection Workgroup, National Patient Navigation Leadership Summit.

    更新日期:2011-08-01 00:00:00

  • Tumor vaccine for ovarian carcinoma targeting sperm protein 17.

    abstract:BACKGROUND:The authors previously identified sperm protein 17 (Sp17) as being expressed in patients with multiple myeloma. The restricted expression of Sp17 in normal tissue makes it an ideal target for tumor vaccine. In the current study, the authors extended their research to include ovarian carcinoma. METHODS:A pai...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10506

    authors: Chiriva-Internati M,Wang Z,Salati E,Timmins P,Lim SH

    更新日期:2002-05-01 00:00:00

  • Intramedullary hemangioblastoma of the spinal cord: definitive management with irradiation.

    abstract::A young woman with a very extensive intramedullary hemangioblastoma of the spinal cord was treated with a moderately high dose of irradiation after biopsy only of the tumor. Now, five years following treatment, there have been no radiation sequelae and no evidence of progressive disease. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800101)45:1<49::aid-cncr282045

    authors: Richardson RG,Griffin TW,Parker RG

    更新日期:1980-01-01 00:00:00

  • T-antigen in normal and neoplastic urothelium.

    abstract::The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820

    authors: Limas C,Lange P

    更新日期:1986-09-15 00:00:00

  • Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma.

    abstract:BACKGROUND:Multicentric breast carcinomas have a higher frequency of axillary lymph node metastasis than unifocal tumors of similar stage. It remains unclear whether this merely reflects larger tumor volumes or a different biologic behavior. The authors have shown previously that when aggregate tumor diameter are used ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11880

    authors: Andea AA,Bouwman D,Wallis T,Visscher DW

    更新日期:2004-01-01 00:00:00

  • Risk-directed therapy for childhood acute lymphoblastic leukemia. Results of the Associazione Italiana Ematologia Oncologia Pediatrica '82 studies.

    abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19931015)72:8<2517::aid-cncr2820

    authors: Vecchi V,Aricò M,Basso G,Ceci A,Madon E,Mandelli F,Masera G,Massimo L,Pession A,Zanesco L

    更新日期:1993-10-15 00:00:00

  • Nonrandom expression of polypeptide hormones in pancreatic endocrine tumors. An immunohistochemical study in a case of multiple islet cell neoplasia.

    abstract::One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880501)61:9<1815::aid-cncr2820

    authors: Pilato FP,D'Adda T,Banchini E,Bordi C

    更新日期:1988-05-01 00:00:00

  • Anterior chemotherapy in esophageal cancer.

    abstract::Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with methotrexate alone. Response rate was in...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851001)56:7<1502::aid-cncr2820

    authors: Advani SH,Saikia TK,Swaroop S,Ramakrishnan G,Nair CN,Dinshaw KA,Sharma S,Vyas JJ,Desai PB

    更新日期:1985-10-01 00:00:00

  • Immune complexes, serum proteins, cell-mediated immunity, and immune regulation in patients with squamous cell carcinoma of the head and neck.

    abstract::A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum prot...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860615)57:12<2295::aid-cncr282

    authors: Veltri RW,Rodman SM,Maxim PE,Baseler MW,Sprinkle PM

    更新日期:1986-06-15 00:00:00

  • Prognostic importance of histologic grading in papillary thyroid carcinoma.

    abstract:BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931101)72:9<2680::aid-cncr2820

    authors: Akslen LA

    更新日期:1993-11-01 00:00:00

  • The efficacy of fiberoptic endoscopic examination and biopsy in the detection of early nasopharyngeal carcinoma.

    abstract::Fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. They all had elevated titers of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma. Each underwent a biopsy from six fixed sites in the na...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910615)67:12<3127::aid-cncr282

    authors: Wei WI,Sham JS,Zong YS,Choy D,Ng MH

    更新日期:1991-06-15 00:00:00

  • Testis cancer. Ichthyosis constitutes a significant risk factor.

    abstract::Testis cancer and ichthyosis are both relatively rare diseases. Hence the finding of six individuals with both these conditions in a small population with testicular cancer is highly conspicuous and indicates some kind of connection among such persons. Despite the identical clinical appearances of their ichthyoses, th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3<730::aid-cncr28206

    authors: Lykkesfeldt G,Bennett P,Lykkesfeldt AE,Micic S,Rørth M,Skakkebaek NE,Svenstrup B

    更新日期:1991-02-01 00:00:00

  • Breast reconstruction. State of the art.

    abstract::Some variant of mastectomy remains the mainstay of the treatment of the primary tumor for the vast majority of the 110,000 new cases of cancer of the breast which will be treated this year in the United States. Reconstruction of the breast after ablation for cancer has become an integral part of the therapeutic regime...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840201)53:3+<809::aid-cncr2820

    authors: Dinner MI,Dowden RV

    更新日期:1984-02-01 00:00:00

  • PEG-IFN-alpha-2b therapy in BCR-ABL-negative myeloproliferative disorders: final result of a phase 2 study.

    abstract:BACKGROUND:Interferon-alpha (IFN-alpha) has shown significant activity in the treatment of BCR-ABL-negative myeloproliferative disorders (MPDs), particularly essential thrombocythemia (ET) and polycythemia vera (PV). PEG-IFN-alpha-2b is a pegylated IFN-alpha-2b with a significant advantage over nonpegylated form in tha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23018

    authors: Jabbour E,Kantarjian H,Cortes J,Thomas D,Garcia-Manero G,Ferrajoli A,Faderl S,Richie MA,Beran M,Giles F,Verstovsek S

    更新日期:2007-11-01 00:00:00

  • Correlation between expression of MUC1 core protein and outcome after surgery in mass-forming intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:It has been reported that MUC1 is an important prognostic factor in several cancers. This study investigated the importance of MUC1 as a prognostic factor in mass-forming intrahepatic cholangiocarcinoma (m-ICC). METHODS:In 50 patients with m-ICC who had undergone hepatectomy, expression of MUC1 was investig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10398

    authors: Matsumura N,Yamamoto M,Aruga A,Takasaki K,Nakano M

    更新日期:2002-03-15 00:00:00

  • Angioimmunoblastic lymphadenopathy: a T-cell deficiency.

    abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420

    authors: Kosmidis PA,Axelrod AR,Palacas C,Stahl M

    更新日期:1978-08-01 00:00:00

  • Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery.

    abstract:BACKGROUND:Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma. METHODS:Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.2 to 23.8 years (median, 3.3 yrs). All living...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21038

    authors: Mendenhall WM,Morris CG,Amdur RJ,Werning JW,Villaret DB

    更新日期:2005-06-01 00:00:00

  • A VM 26-based regimen for patients with previously untreated non-Hodgkin lymphoma. Prolonged disease-free survival in patients younger than 60 years of age: a phase II trial of the eastern Cooperative Oncology Group.

    abstract:BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19930115)71:2<464::aid-cncr28207

    authors: Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

    更新日期:1993-01-15 00:00:00