Testis cancer. Ichthyosis constitutes a significant risk factor.


:Testis cancer and ichthyosis are both relatively rare diseases. Hence the finding of six individuals with both these conditions in a small population with testicular cancer is highly conspicuous and indicates some kind of connection among such persons. Despite the identical clinical appearances of their ichthyoses, three of the ichthyotic subjects had no measurable activity of the enzyme, steroid sulfatase (STS) in leucocytes, a distinct characteristic of recessive X-linked ichthyosis (RXLI). However, the remaining three subjects had normal STS activity, a strong indicator of autosomal dominant ichthyosis (ADI). The STS activity in patients with testicular cancer who do not have ichthyosis (N = 30) was also within the normal range. The patients with testicular cancer with no skin disease had elevated serum levels of 4-androstenedione (4-AD), follicle stimulating hormone (FSH), and luteinizing hormone (LH) but had reduced levels of estrone and estrone sulfate. The other serum parameters measured did not significantly differ from normal levels. In essence, the hormone levels obtained for the patients with ichthyotic testicular cancer followed the same pattern, although their dehydroepiandrosterone sulfate (DHEAS) and estrone sulfate levels tended to be slightly higher than normal. However, no conspicuous aberrations in any of the parameters examined were observed, and why men with ichthyosis are at high risk for testicular cancer remains an unresolved issue.






Lykkesfeldt G,Bennett P,Lykkesfeldt AE,Micic S,Rørth M,Skakkebaek NE,Svenstrup B




Has Abstract


1991-02-01 00:00:00














  • An assessment of World Health Organization criteria for severe acute respiratory syndrome in patients with cancer.

    abstract:BACKGROUND:The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or to...


    pub_type: 杂志文章


    authors: Gu J,Wu A,Li J,Zhang X,Fang J,Li M,Yao Y,Ke Y,Gu J,Chen M,You W

    更新日期:2004-04-01 00:00:00

  • Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS:We conduc...


    pub_type: 杂志文章


    authors: El-Jawahri AR,Vandusen HB,Traeger LN,Fishbein JN,Keenan T,Gallagher ER,Greer JA,Pirl WF,Jackson VA,Spitzer TR,Chen YB,Temel JS

    更新日期:2016-03-01 00:00:00

  • Outreach by the Hanford Tribal Service Program to Indian communities around the Hanford Nuclear Reservation.

    abstract:BACKGROUND:The Hanford Tribal Service Program offers technical assistance and health education to American Indian tribes in an area reported to be affected by radiation from the Hanford Nuclear Reservation, which was developed and operated by the United States federal government. This article describes strategies used ...


    pub_type: 杂志文章


    authors: Jensen RA

    更新日期:1996-10-01 00:00:00

  • Precision radiotherapy for hemangiopericytomas of the central nervous system.

    abstract:BACKGROUND:Radiotherapy (RT) plays a major role in the management of hemangiopericytomas (HAP). The present analysis evaluates the role of precision RT in the management of HAP of the central nervous system (CNS) and represents one of the largest series of HAP treated with RT that can be found in the literature. METHO...


    pub_type: 杂志文章


    authors: Combs SE,Thilmann C,Debus J,Schulz-Ertner D

    更新日期:2005-12-01 00:00:00

  • Utilization and expense of adjuvant cancer therapies following radical prostatectomy.

    abstract:BACKGROUND:We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt. METHODS:We used SEER-Medicare data from 2004-2006 to identify 4247 men who underwent RP, of whom 600 subsequently received adjuvant therapies. We used Cox regression to ident...


    pub_type: 杂志文章


    authors: Williams SB,Gu X,Lipsitz SR,Nguyen PL,Choueiri TK,Hu JC

    更新日期:2011-11-01 00:00:00

  • Transient neurologic disturbances induced by high-dose methotrexate treatment.

    abstract::Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose a...


    pub_type: 杂志文章


    authors: Jaffe N,Takaue Y,Anzai T,Robertson R

    更新日期:1985-09-15 00:00:00

  • Extranodal small lymphocytic proliferation: a clinicopathologic and immunocytochemical study.

    abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...


    pub_type: 杂志文章


    authors: Evans HL

    更新日期:1982-01-01 00:00:00

  • Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian.

    abstract:BACKGROUND:Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS:An i...


    pub_type: 杂志文章


    authors: Mersch J,Jackson MA,Park M,Nebgen D,Peterson SK,Singletary C,Arun BK,Litton JK

    更新日期:2015-01-15 00:00:00

  • Intraoperative gamma detection reveals abdominal endocrine tumors more efficiently than somatostatin receptor scintigraphy.

    abstract:BACKGROUND:[(111)In]-diethylenetriamine pentaacetic acid (DTPA)-D-[Phe1]-octreotide (OctreoScan, Mallinckrodt Medical, Petten, The Netherlands), combined with single photon emission computed tomography (SPECT), has limited possibilities to detect small abdominal endocrine tumors. This study explores the efficacy of Oct...


    pub_type: 杂志文章


    authors: Ohrvall U,Westlin JE,Nilsson S,Juhlin C,Rastad J,Lundqvist H,Akerström G

    更新日期:1997-12-15 00:00:00

  • Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study.

    abstract::The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow-cytometric technique. The DNA pattern has been related to the duration of the disease, and to histopathology. Aneuploid cell lines were found in eight patients, two of which had histopathological...


    pub_type: 杂志文章


    authors: Hammarberg C,Slezak P,Tribukait B

    更新日期:1984-01-15 00:00:00

  • HL-A in cancer family "N".

    abstract::Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer-prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL-A haplotype, HL-A2-HL-A12 (relativ...


    pub_type: 杂志文章


    authors: Lynch HT,Thomas RJ,Terasaki PI,Ting A,Guirgis HA,Kaplan AR,Magee H,Lynch J,Kraft C,Chaperon E

    更新日期:1975-10-01 00:00:00

  • Mitoxantrone for refractory and relapsed acute leukemia.

    abstract::Seventy-seven patients with relapsed or refractory acute leukemia and three with acute blastic chronic myeloid leukemia (CML) were treated in an open Phase II study using mitoxantrone 12 mg/m2 intravenously daily X 5 days. Complete remission (CR) was achieved in 32 of 80 (40%), including 23/45 (52%) with relapsed acut...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Bezwoda WR,Bernasconi C,Hutchinson RM,Winfield DA,de Bock R,Mandelli F

    更新日期:1990-08-01 00:00:00

  • Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma.

    abstract:BACKGROUND:Ribonucleotide reductase M1 (RRM1) is an important molecule in different types of cancer. The objective of this study was to evaluate the predictive roles of RRM1 in the survival of patients with resectable pancreatic adenocarcinoma who received treatment with gemcitabine or nongemcitabine adjuvant therapy. ...


    pub_type: 杂志文章


    authors: Xie H,Jiang W,Jiang J,Wang Y,Kim R,Liu X,Liu X

    更新日期:2013-01-01 00:00:00

  • Bowenoid dysplasia of the vulva.

    abstract::The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...


    pub_type: 杂志文章


    authors: Ulbright TM,Stehman FB,Roth LM,Ehrlich CE,Ransburg RC

    更新日期:1982-12-15 00:00:00

  • Real-time identification of liver cancers by using indocyanine green fluorescent imaging.

    abstract:BACKGROUND:We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compresse...


    pub_type: 杂志文章


    authors: Ishizawa T,Fukushima N,Shibahara J,Masuda K,Tamura S,Aoki T,Hasegawa K,Beck Y,Fukayama M,Kokudo N

    更新日期:2009-06-01 00:00:00

  • Lung cancer in patients younger than 40 years of age.

    abstract::The records of 52 patients younger than 40 years of age who had bronchogenic carcinoma diagnosed between 1965 and 1985 were reviewed. The preponderance of adenocarcinoma (54%), the lower male-female ratio in this age group compared with patients age 40 or older (2:1), the importance of cigarette smoking as a causative...


    pub_type: 杂志文章


    authors: Jubelirer SJ,Wilson RA

    更新日期:1991-03-01 00:00:00

  • A proposed staging system for primary gastric lymphoma.

    abstract:BACKGROUND:Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. METHODS:The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates wer...


    pub_type: 杂志文章


    authors: Shimodaira M,Tsukamoto Y,Niwa Y,Goto H,Hase S,Hayakawa T,Nagasaka T

    更新日期:1994-06-01 00:00:00

  • The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site.

    abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...


    pub_type: 杂志文章,评审


    authors: Sève P,Billotey C,Broussolle C,Dumontet C,Mackey JR

    更新日期:2007-01-15 00:00:00

  • Combination chemotherapy (CMFVP) versus L-phenylalanine mustard (L-PAM) for operable breast cancer with positive axillary nodes: a Southwest Oncology Group Study.

    abstract::The Southwest Oncology Group in a prospective randomized study compared one year of adjuvant combination chemotherapy with continuous CMFVP to two years of intermittent L-PAM in women with operable breast cancer with histologically positive axillary lymph nodes. In fully evaluable patients with a 42-month median and 3...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Glucksberg H,Rivkin SE,Rasmussen S,Tranum B,Gad-el-Mawla N,Costanzi J,Hoogstraten B,Athens J,Maloney T,McCracken J,Vaughn C

    更新日期:1982-08-01 00:00:00

  • Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible.

    abstract:BACKGROUND:Adenosquamous/squamous cell carcinoma of the gallbladder generally has been considered a lethal disease. The objective of this study was to clarify the effectiveness of resection for patients with adenosquamous/squamous cell carcinoma of the gallbladder. METHODS:Twenty-nine patients who underwent resection ...


    pub_type: 杂志文章


    authors: Oohashi Y,Shirai Y,Wakai T,Nagakura S,Watanabe H,Hatakeyama K

    更新日期:2002-06-01 00:00:00

  • Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature.

    abstract:BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of...


    pub_type: 杂志文章,评审


    authors: Joyama S,Ueda T,Shimizu K,Kudawara I,Mano M,Funai H,Takemura K,Yoshikawa H

    更新日期:1999-10-01 00:00:00

  • Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.

    abstract:BACKGROUND:Multiple cell-signaling ligands and receptors-including vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), endothelial growth factor (EGF), v-akt murine thymoma viral oncogene homolog (AKT), platelet-derived growth factor (PDGF), mitogen-activated protein kinase (MAPK), and 70-kilod...


    pub_type: 杂志文章


    authors: Abdeen A,Chou AJ,Healey JH,Khanna C,Osborne TS,Hewitt SM,Kim M,Wang D,Moody K,Gorlick R

    更新日期:2009-11-15 00:00:00

  • Retinitis pigmentosa and colon cancer: a previously unreported association.

    abstract::Retinitis pigmentosa, a hereditary disease characterized by progressive retinal degeneration and blindness, has been associated with numerous diseases. We report the first association between retinitis pigmentosa and colon cancer in 3 of 53 hospitalized patients with retinitis pigmentosa at the Massachusetts General H...


    pub_type: 杂志文章


    authors: Winzelberg GG,Greenstein R,Ferrucci JT Jr

    更新日期:1980-06-01 00:00:00

  • Stage III nodular lymphoreticular tumors (non-Hodgkin's lymphoma): results of central lymphatic irradiation.

    abstract::Since 1969, 29 previously untreated patients with Stage III nodular malignant lymphoreticular (MLT) have received total central lymphatic (TCL) irradiation. The volume irradiated included the entire abdomen, Waldeyer's ring, and preauricular nodes in addition to the usual regions encompassed by total nodal irradiation...


    pub_type: 杂志文章


    authors: Cox JD,Komaki R,Kun LE,Wilson JF,Greenberg M

    更新日期:1981-05-01 00:00:00

  • Angioimmunoblastic lymphadenopathy: a T-cell deficiency.

    abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...


    pub_type: 杂志文章


    authors: Kosmidis PA,Axelrod AR,Palacas C,Stahl M

    更新日期:1978-08-01 00:00:00

  • Beta-glucuronidase activity in prostatic carcinoma and benign prostatic hyperplasia.

    abstract::Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demo...


    pub_type: 杂志文章


    authors: Pearson JP,Pretlow TP,Bradley EL Jr,McGinnis MC,Pretlow TG

    更新日期:1989-08-15 00:00:00

  • A correlation of argyrophilic nucleolar organizer regions with stages of hepatocellular carcinoma.

    abstract:BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...


    pub_type: 杂志文章


    authors: Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

    更新日期:1993-01-01 00:00:00

  • Mesothelioma following Wilms' tumor in childhood.

    abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...


    pub_type: 杂志文章


    authors: Antman KH,Ruxer RL Jr,Aisner J,Vawter G

    更新日期:1984-07-15 00:00:00

  • Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trial: The Radiologic Diagnostic Oncology Group 5 Study. The RDOG5 investigators.

    abstract:BACKGROUND:Radiologic Diagnostic Oncology Group 5 is a multicenter clinical trial designed to evaluate fine-needle aspiration (FNA) of nonpalpable breast lesions performed by multiple operators using the same protocol. METHODS:Four hundred and nineteen women with mammographically detected nonpalpable breast lesions we...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Pisano ED,Fajardo LL,Tsimikas J,Sneige N,Frable WJ,Gatsonis CA,Evans WP,Tocino I,McNeil BJ

    更新日期:1998-02-15 00:00:00

  • Is screening for breast cancer cost-effective?

    abstract::As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...


    pub_type: 杂志文章


    authors: Mushlin AI,Fintor L

    更新日期:1992-04-01 00:00:00