T-antigen in normal and neoplastic urothelium.

Abstract:

:The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avidin-peroxidase system or a modified red cell adherence test. In vitro treatment of the tissue sections with neuraminidase induced PNA binding in the normal and neoplastic urothelium as well as the red blood cells and the vascular endothelium. Spontaneous PNA binding was absent in normal bladder epithelium, but was observed in 10% of the noninvasive and 65% of the invasive transitional cell carcinomas (TCC). The positive reactions were seen in the cytoplasm, cell surface, and mucin. These results were correlated with the light and electron microscopic findings and with the detectability of the A, B, H blood group antigens in the same tissues. Ultrastructurally, the PNA binding sites frequently corresponded to the Golgi apparatus and to secretory products which stained with Alcian blue. About 90% of TCCs with spontaneous PNA binding did not express the expected blood group antigen. The latter was also undetectable in 54% of TCCs lacking spontaneous PNA binding. It appears, therefore, that the expression of T-antigen occurs later in the evolution of aggressive TCCs, usually when they have advanced to invasive stages. The finding of spontaneous T-antigen unmasking correlates with the presence of invasion and a higher risk for metastatic involvement of regional lymph nodes.

journal_name

Cancer

journal_title

Cancer

authors

Limas C,Lange P

doi

10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820

subject

Has Abstract

pub_date

1986-09-15 00:00:00

pages

1236-45

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

58

pub_type

杂志文章

相关文献

CANCER文献大全
  • Barriers to health care contribute to delays in follow-up among women with abnormal cancer screening: Data from the Patient Navigation Research Program.

    abstract:BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29607

    authors: Ramachandran A,Snyder FR,Katz ML,Darnell JS,Dudley DJ,Patierno SR,Sanders MR,Valverde PA,Simon MA,Warren-Mears V,Battaglia TA,Patient Navigation Research Program Investigators.

    更新日期:2015-11-15 00:00:00

  • Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior.

    abstract::Since primary lymphoma of bone (PLB) exhibits morphologic diversity and variability in individual survival, we analyzed the relationship between histopathologic features and biological behavior in 33 patients treated at the Massachusetts General Hospital. Three major histologic subgroups were identified, based on a va...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820901)50:5<1009::aid-cncr2820

    authors: Dosoretz DE,Raymond AK,Murphy GF,Doppke KP,Schiller AL,Wang CC,Suit HD

    更新日期:1982-09-01 00:00:00

  • A retrospective study of 370 borderline tumors of the ovary treated at the Norwegian Radium Hospital from 1970 to 1982. A review of clinicopathologic features and treatment modalities.

    abstract:METHODS:Three-hundred seventy patients with borderline tumors treated between 1970 and 1982 at the Norwegian Radium Hospital were analyzed retrospectively for clinicopathologic features, treatment, and survival characteristics. RESULTS:One hundred seventy-eight patients had mucinous tumors, 174 patients had serous tum...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930301)71:5<1810::aid-cncr2820

    authors: Kaern J,Tropé CG,Abeler VM

    更新日期:1993-03-01 00:00:00

  • Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel.

    abstract:BACKGROUND:Radiation recall refers to a tissue reaction produced by a chemotherapeutic agent in a previously irradiated field that would not occur in a nonirradiated field. A number of agents have been reported to cause radiation recall. Recently, there have been case reports of recall dermatitis from paclitaxel treatm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950915)76:6<1069::aid-cncr2820

    authors: Schweitzer VG,Juillard GJ,Bajada CL,Parker RG

    更新日期:1995-09-15 00:00:00

  • Role of cancer survivor health and health service use in spouses' use of mental health-related care.

    abstract:BACKGROUND:Spouses of cancer survivors are at an increased risk of poor mental health outcomes but are known to underuse supportive services. The objective of the current study was to determine how the health and health care use of cancer survivors were associated with depression and anxiety-related health care use in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33345

    authors: Litzelman K,Choi H,Maher ME,Harnish A

    更新日期:2020-12-08 00:00:00

  • Disease control intervals in high-risk neuroblastoma.

    abstract:BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23507

    authors: Santana VM,Furman WL,McGregor LM,Billups CA

    更新日期:2008-06-15 00:00:00

  • The relationship of the possible hepatic toxicity of chemotherapeutic drugs and carcinoembryonic antigen elevation.

    abstract::The value of the serum level of carcinoembryonic antigen (CEA) as an indicator of recurrent colorectal carcinoma has been accepted, and the use of serial CEA levels to monitor postoperative chemotherapy has been suggested, However, elevated CEA levels may be associated with nonneoplastic conditions, of which the most ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810201)47:3<481::aid-cncr28204

    authors: Savrin RA,Martin EW Jr

    更新日期:1981-02-01 00:00:00

  • Nonlymphoblastic T-cell lymphoma in children.

    abstract::Three children with nonlymphoblastic, non-Hodgkin's lymphomas, showed morphologic features that suggested nonlymphoblastic T-cell origin. Tissue for immunologic study was available from two of the three patients; both showed immunophenotypes of T-cells. Although nearly all T-cell lymphomas in children are lymphoblasti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2099::aid-cncr282

    authors: Bitter MA,Nachman J,Jones N,Franklin WA,Le Beau MM,Vardiman JW

    更新日期:1987-06-15 00:00:00

  • Mesothelioma following Wilms' tumor in childhood.

    abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205

    authors: Antman KH,Ruxer RL Jr,Aisner J,Vawter G

    更新日期:1984-07-15 00:00:00

  • Prognostic ability of simplified nuclear grading of renal cell carcinoma.

    abstract:BACKGROUND:The Fuhrman grading system is an established predictor of survival in patients with renal cell carcinoma (RCC). The predictive accuracy of various Fuhrman grading schemes was tested with the intent of improving the prediction of RCC-specific survival (RCC-SS). METHODS:The analyses targeted 5453 patients fro...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22463

    authors: Rioux-Leclercq N,Karakiewicz PI,Trinh QD,Ficarra V,Cindolo L,de la Taille A,Tostain J,Zigeuner R,Mejean A,Patard JJ

    更新日期:2007-03-01 00:00:00

  • Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma.

    abstract::A clinicopathologic analysis of 12 cases of a morphologically distinctive non-Hodgkin's malignant lymphoma which appeared to arise from the mantle zones of secondary lymphoid follicles is presented. In lymph node and spleen sections, atypical small lymphoid cells with slightly irregular and indented nuclear contours p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820401)49:7<1429::aid-cncr2820

    authors: Weisenburger DD,Kim H,Rappaport H

    更新日期:1982-04-01 00:00:00

  • A phase II study of dacarbazine and cisplatin in combination with outpatient administered interleukin-2 in metastatic malignant melanoma.

    abstract:BACKGROUND:Based on prior experience with dacarbazine (DTIC) and an outpatient interleukin-2 (IL-2) regimen, the current study was conducted to improve the antitumor efficacy and assess the immunologic interactions between chemotherapy and IL-2. METHODS:Thirty-two patients were registered onto a treatment program, whi...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19930601)71:11<3520::aid-cncr282

    authors: Flaherty LE,Robinson W,Redman BG,Gonzalez R,Martino S,Kraut M,Valdivieso M,Rudolph AR

    更新日期:1993-06-01 00:00:00

  • Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma.

    abstract:BACKGROUND:Studies of colorectal adenocarcinoma (CRC) indicate a higher mortality rate for African Americans compared with Caucasians in the United States. In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20337

    authors: Alexander D,Chatla C,Funkhouser E,Meleth S,Grizzle WE,Manne U

    更新日期:2004-07-01 00:00:00

  • Interferon-beta can induce progesterone receptors in human endometrial adenocarcinoma.

    abstract:BACKGROUND:The induction of estrogen and progesterone receptors (ER and PGR) has been reported in breast and endometrial cancer cells exposed to human fibroblast interferon-beta (hIFN-beta). Clinical verification of this finding might provide the rationale for new therapeutic approaches. This study was designed to eval...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960801)78:3<448::AID-CNC

    authors: Codegoni AM,Landoni F,Lomonico S,Losa G,Mangioni C,Taverna M,Lucchini V,D'Incalci M

    更新日期:1996-08-01 00:00:00

  • Efficacy of follow-up bone scans in carcinoma of the prostate.

    abstract::Three hundred fifteen radioisotopic bone scans ranging from initial scan only to nine scans per patient, performed on 114 patients with adenocarcinoma of the prostate between 1979 and 1984, were reviewed. Seventeen patients had positive scans, ten on initial scan and seven at follow-up. Nine patients had bone pain at ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880615)61:12<2453::aid-cncr282

    authors: Corrie D,Timmons JH,Bauman JM,Thompson IM

    更新日期:1988-06-15 00:00:00

  • Immunoblastic sarcoma of B-cells in a 24-month-old child. Report of a case.

    abstract::Immunoblastic sarcoma is a malignancy of transformed lymphocytes with a high association of occurrence in patients with immune disorders. The youngest previously reported case occurred in a 6-year-old child with immunoblastic lymphadenopathy. The authors report the finding of immunoblastic sarcoma of B-cells in a prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841101)54:9<2032::aid-cncr2820

    authors: Larson T,Katz DA,Mailliard JA

    更新日期:1984-11-01 00:00:00

  • Nonaspirin nonsteroidal anti-inflammatory drugs and gastric cancer risk after Helicobacter pylori eradication: A territory-wide study.

    abstract:BACKGROUND:Despite Helicobacter pylori (HP) eradication, individuals can still develop gastric cancer (GC). Prior studies have demonstrated that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) reduce the risk of GC, but this may be caused by immortal time bias and failure to adjust for HP status. The object...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33412

    authors: Li B,Cheung KS,Wong IY,Leung WK,Law S

    更新日期:2021-01-20 00:00:00

  • Immunohistologic detection of lymphocyte subpopulations infiltrating in human oral cancer with special reference to its clinical significance.

    abstract::Cancer tissues from 30 patients with squamous cell carcinoma of the oral cavity were examined immunohistopathologically as to the responsiveness of the host against its own cancer cells in both biopsy and surgically resected specimens from the same patients. Subpopulations of the infiltrating lymphocytes in cancer tis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840601)53:11<2456::aid-cncr282

    authors: Hiratsuka H,Imamura M,Ishii Y,Kohama G,Kikuchi K

    更新日期:1984-06-01 00:00:00

  • Systematic pelvic and aortic lymphadenectomy in elderly gynecologic oncologic patients.

    abstract:BACKGROUND:Retroperitoneal lymph node dissection is a fundamental step in the surgical management of patients with pelvic gynecologic malignancies, but its applicability to geriatric patients is controversial. The objective of this study was to evaluate whether pelvic and aortic lymphadenectomy in elderly patients with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011115)92:10<2562::aid-cncr160

    authors: Giannice R,Susini T,Ferrandina G,Poerio A,Margariti PA,Carminati R,Marana E,Mancuso S,Scambia G

    更新日期:2001-11-15 00:00:00

  • The coexistence of lymphangiosarcoma and Kaposi's sarcoma in a renal transplant recipient.

    abstract::A case of coexisting lymphangiosarcoma and Kaposi's sarcoma that occurred in a female renal transplant recipient is presented. Both sarcomas were localized to the skin and were slowly progressive over several years. The coexistence of these two sarcomas may indicate that they arose from a common precursor endothelial ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911115)68:10<2330::aid-cncr282

    authors: Studniberg HM,Rivers JK,Cooke BE,Barnetson RS

    更新日期:1991-11-15 00:00:00

  • Aggressive stage I grade 1 endometrial carcinoma.

    abstract:BACKGROUND:Patients with Stage I Grade 1 endometrial carcinoma have an excellent prognosis and a 10-year survival rate of more than 90%. In every clinical series, however, a few patients in this group have recurrence and die of their disease. METHODS:The authors reviewed 80 patients with Stage I Grade 1 endometrial ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920815)70:4<790::aid-cncr28207

    authors: Tornos C,Silva EG,el-Naggar A,Burke TW

    更新日期:1992-08-15 00:00:00

  • Non-Hodgkin's lymphoma: patterns of relapse from complete remission after combination chemotherapy.

    abstract::An analysis of patterns of relapse from complete remission in patients with non-Hodgkin's lymphoma treated with combination chemotherapy has demonstrated differences between histologic subgroups. Patients with diffuse histiocytic lymphoma who achieved a histologically proven complete remission after 6 months of treatm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197502)35:2<354::aid-cncr2820350

    authors: Schein PS,Chabner BA,Canellos GP,Young RC,DeVita VT Jr

    更新日期:1975-02-01 00:00:00

  • Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease.

    abstract::The livers of 345 autopsy cases of chronic liver disease were examined for macroregenerative nodule (MRN), a large nodular lesion more than 10 mm in diameter. A total of 86 lesions of MRN was found in 49 cases (14.2%): 32 were from 191 cases of hepatocellular carcinoma (HCC), 16 were from 148 cases of cirrhosis only, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880101)61:1<99::aid-cncr282061

    authors: Furuya K,Nakamura M,Yamamoto Y,Togei K,Otsuka H

    更新日期:1988-01-01 00:00:00

  • Diabetes in relation to Barrett's esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett's and Esophageal Adenocarcinoma Consortium.

    abstract:BACKGROUND:Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. METHODS:Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32444

    authors: Petrick JL,Li N,Anderson LA,Bernstein L,Corley DA,El Serag HB,Hardikar S,Liao LM,Liu G,Murray LJ,Rubenstein JH,Schneider JL,Shaheen NJ,Thrift AP,van den Brandt PA,Vaughan TL,Whiteman DC,Wu AH,Zhao WK,Gammon MD,Coo

    更新日期:2019-12-01 00:00:00

  • The spectrum of cytologic features in nonproliferative breast lesions.

    abstract:BACKGROUND:The reliability of cytologic criteria to classify nonproliferative breast lesions (NPBL) is still debated. Sampling error and heterogeneity of breast lesions complicates the histologic correlation of fine-needle aspiration results further. METHODS:To provide optimal cytohistologic correlation, two smears (o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.9020

    authors: Sidawy MK,Tabbara SO,Bryan JA,Poprocky LA,Frost AR

    更新日期:2001-04-25 00:00:00

  • Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group.

    abstract:BACKGROUND:This study sought to investigate biological/clinicopathological characteristics of neuroblastoma, undifferentiated subtype (NBUD). METHODS:This study examined 157 NBUD cases filed at the Children's Oncology Group Neuroblastoma Pathology Reference Laboratory, and survival rates of the patients were analyzed ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28251

    authors: Wang LL,Suganuma R,Ikegaki N,Tang X,Naranjo A,McGrady P,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Shimada H

    更新日期:2013-10-15 00:00:00

  • Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.

    abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25099

    authors: Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

    更新日期:2010-06-15 00:00:00

  • Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors.

    abstract:BACKGROUND:Intracranial primitive neuroectodermal tumors (PNETs) occur in the supratentorial and infratentorial regions of the brain. Although histologically similar, the natural history of the tumor at each site differs. The study goal was to determine whether there was evidence of a genetic difference between suprate...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990715)86:2<331::aid-cnc

    authors: Russo C,Pellarin M,Tingby O,Bollen AW,Lamborn KR,Mohapatra G,Collins VP,Feuerstein BG

    更新日期:1999-07-15 00:00:00

  • Prostate carcinoma risk subsequent to diagnosis of benign prostatic hyperplasia: a population-based cohort study in Sweden.

    abstract:BACKGROUND:Pathologically, benign prostatic hyperplasia (BPH) is not considered a precursor for prostate carcinoma. However, because the two conditions share not only a similar hormonal environment within the prostate but also several common risk factors, it is possible that men with BPH may be at increased risk of pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11710

    authors: Chokkalingam AP,Nyrén O,Johansson JE,Gridley G,McLaughlin JK,Adami HO,Hsing AW

    更新日期:2003-10-15 00:00:00

  • Transformation of Hodgkin's disease into malignant fibrous histiocytoma.

    abstract::The continuity that exists between Hodgkin's disease and the fibrohistiocytoses has only recently been recognized. Four cases are presented that illustrate this phenomenon. The fibrohistiocytic component of the Hodgkin's lesion may lag behind the lymphoreticular component, may be present in equal proportion, or may as...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860115)57:2<264::aid-cncr28205

    authors: Suster S

    更新日期:1986-01-15 00:00:00