当前位置： SCI文献检索 > CANCER期刊下所有文献 > Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.

Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.

Abstract：

BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked cancer and birth registry data from 5 US states from 1978 through 2004. Data were available for 13,249 cancer cases and 36,996 controls selected from birth records. Parental race/ethnicity was determined from birth records. Logistic regression analysis was used to examine the association of cancer with different racial/ethnic groups. RESULTS:Compared with whites, blacks had a 28% decreased risk of cancer (odds ratio [OR], 0.72; 95% confidence interval [95% CI], 0.65-0.80), whereas both Asians and Hispanics had an approximate 15% decrease. Children of mixed white/black ancestry also were found to be at decreased risk (OR, 0.71; 95% CI, 0.56-0.90), but estimates for mixed white/Asian and white/Hispanic children did not differ from those of whites. Compared with whites: 1) black and mixed white/black children had decreased ORs for acute lymphoblastic leukemia (OR, 0.39 [95% CI, 0.31-0.49] and OR, 0.58 [95% CI, 0.37-0.91], respectively); 2) Asian and mixed white/Asian children had decreased ORs for brain tumors (OR, 0.51 [95% CI, 0.39-0.68] and OR, 0.79 [95% CI, 0.54-1.16], respectively); and 3) Hispanic and mixed white/Hispanic children had decreased ORs for neuroblastoma (OR, 0.51 [95% CI, 0.42-0.61] and OR, 0.67 [95% CI, 0.50-0.90], respectively). CONCLUSIONS:Children of mixed ancestry tend to have disease risks that are more similar to those of racial/ethnic minority children than the white majority group. This tendency may help formulate etiologic studies designed to study possible genetic and environmental differences more directly.

journal_name

Cancer

journal_title

Cancer

authors

Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

doi

10.1002/cncr.25099

subject

Has Abstract

pub_date

2010-06-15 00:00:00

pages

3045-53

issue

eissn

0008-543X

issn

1097-0142

journal_volume

116

pub_type

杂志文章

在线工具

Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.