Abstract:
:Twenty patients with locally advanced and/or metastatic transitional cell cancer of the urinary tract were treated with cyclophosphamide 500 mg/m2, Adriamycin (doxorubicin) 40 mg/m2 and cis-platinum (CDDP) 40 mg/m2 given every three weeks for 2 cycles, alternating with methotrexate 40 mg/m2 weekly for six weeks (CAP-M). Five of thirteen (38%) evaluable patients responded, with a significant prolongation of survival. Toxicity in 18 evaluable patients was mild to moderate. Methotrexate can be combined with CAP with significant reduction in dosage of cyclophosphamide, Adriamycin and CDDP and reduced toxicity, without major loss of efficacy. The precise role of methotrexate in combination chemotherapy of bladder cancer remains to be defined.
journal_name
Cancerjournal_title
Cancerauthors
Citrin DL,Hogan TF,Davis TEdoi
10.1002/1097-0142(19830101)51:1<1::aid-cncr2820510subject
Has Abstractpub_date
1983-01-01 00:00:00pages
1-4issue
1eissn
0008-543Xissn
1097-0142journal_volume
51pub_type
杂志文章相关文献
CANCER文献大全abstract::One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<772::aid-cncr28206
更新日期:1987-08-15 00:00:00
abstract::A primary yolk-sac (endodermal sinus) tumor of the prostate occurring in a 51-year-old man is described, and the difficulties associated with classification of this tumor are discussed. Yolk-sac tumors have been reported to arise in several extragonadal sites, but to our knowledge this is the first documented case of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197804)41:4<1395::aid-cncr282041
更新日期:1978-04-01 00:00:00
abstract::Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the sec...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.30588
更新日期:2017-06-15 00:00:00
abstract::A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC-CT), CT with water-soluble contrast (WSC-CT), and CT with ethiodized oil emulsion (EOE-CT) were performed on patients with possible or probab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1489::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract:BACKGROUND:Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20847
更新日期:2005-02-15 00:00:00
abstract:BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3947::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract::Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820901)50:5<962::aid-cncr28205
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:Coagulopathies often are associated with malignant tumors. The pathogenesis of these complications in cancer is not clear. Host inflammatory (monocyte/macrophage) cell-mediated triggering of clotting activation has been suggested. METHODS:The objective of this study was to evaluate the role of neutrophil-de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931001)72:7<2134::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract::The records of 12 patients with a diagnosis of pinealoma or ectopic pinealoma irradiated at Montefiore Hospital and Medical Center between 1961 and 1971 were reviewed. Diagnosis was made clinically and radiographically. Histology is available in three cases. Eight cases were treated with small fields (4 X 4 to 6 X 8 c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197606)37:6<2713::aid-cncr282037
更新日期:1976-06-01 00:00:00
abstract::The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890801)64:3<691::aid-cncr28206
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Severe fatigue is a common and distressing symptom affecting approximately one in four survivors of breast cancer. The current study examined the efficacy of Internet-based cognitive behavioral therapy (ICBT) for severe fatigue in survivors of breast cancer compared with care as usual (CAU). METHODS:The aut...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.30815
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connecte...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0142(19960101)77:1<138::AID-CNC
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (NSCLC) by the administration of carboplatin plus gemcitabine followed by of paclitaxel. METHODS:Patients with Stage IIIB (pleural effusion) or ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010701)92:1<146::aid-cncr1302>
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:: The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy. METHODS:: The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24891
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Cytotoxic analogs of somatostatin (SST), such as AN-238, which consists of 2-pyrrolinodoxorubicin (AN-201) linked to the SST carrier RC-121, can be targeted to tumors that express SST receptors. Because SST receptors are present in ovarian carcinoma cells, the authors evaluated the effect of AN-238 on the UC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1168::aid-cncr1435
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19940501)73:9<2359::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Fadrozole hydrochloride (CGS 16949A) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. Circulating estradiol, estrone, and estrone sulfate are reduc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990101)85:1<100::aid-cnc
更新日期:1999-01-01 00:00:00
abstract::Ninety-five patients with non-oat cell lung cancer underwent resection of all apparent disease and were followed for a minimum of 36 months. Incidence of recurrence was 34% in 47 patients with N0 disease, 65% in 32 patients with N1 disease, and 81.3% in 16 patients with N2 disease (P less than 0.02 and P less than 0.0...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<471::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract::Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.32078
更新日期:2019-07-15 00:00:00
abstract::A case of congenital acute lymphoblastic leukemia (ALL) displayed an X;6 translocation. This is the third reported case of ALL with an X;6 translocation. In addition, two of the three ALL cases occurred during infancy, at ages 2 months and newborn, and both translocations involved the band q15-16 region of chromosome ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920201)69:3<799::aid-cncr28206
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The authors investigated the prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction in a contemporary, population-based prostate cancer cohort. They also explored the associations between baseline function and age, comorbidity, and timing of baseline survey completion with respect to tre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28563
更新日期:2014-04-15 00:00:00
abstract:BACKGROUND:Estimates of the fecal occult blood test (FOBT) (Hemoccult II) sensitivity differed widely between screening trials and led to divergent conclusions on the effects of FOBT screening. We used microsimulation modeling to estimate a preclinical colorectal cancer (CRC) duration and sensitivity for unrehydrated F...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24256
更新日期:2009-06-01 00:00:00
abstract::Reflected ultrasound scanning (echography) is rapidly developing into a prime tool for tumor diagnosis, outlining, and detection. The principles of echographic diagnosis of neoplasms, the accepted uses in detection and diagnosis, as well as some of the principles of internal and contour patterns are discussed. Echogra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1+<496::aid-cncr282037
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS:Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26034
更新日期:2011-09-15 00:00:00
abstract::In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This ar...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19931201)72:11+<3484::aid-cncr28
更新日期:1993-12-01 00:00:00
abstract::A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19840301)53:5<1209::aid-cncr2820
更新日期:1984-03-01 00:00:00
abstract::From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910515)67:10<2506::aid-cncr282
更新日期:1991-05-15 00:00:00
abstract::Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2353::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract::Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197807)42:1<127::aid-cncr2820420
更新日期:1978-07-01 00:00:00