Abstract:
BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or not receiving adjuvant therapy. METHODS:The immunostaining for HER-2/neu oncoprotein was performed on formaldehyde-solution-fixed, paraffin-embedded sections of 888 node-positive breast cancers resected between 1980 and 1986 and for which a follow-up of 2.5-10.5 years was available. The staining was performed using a polyclonal antibody (dilution, 1/15). RESULTS:One hundred forty-three cases (16.1%) revealed a positive membrane staining with or without additional cytoplasmic contribution, whereas cytoplasmic staining alone was noted in 118 cases (13.3%). Positive membrane staining was correlated with more involved lymph nodes (P = 0.005), aneuploidy (P = 0.002), poor nuclear (P < 0.0001) and histologic (P = 0.007) grades, absence of estrogen (P < 0.0001) and progesterone (P < 0.0001) receptor content, and cathepsin D expression (P = 0.009). No relation was found (P > 0.05) with either age, tumor size, or HSP27 expression. Membrane staining was strongly associated with poor distant metastasis-free or overall survival rate (P < 0.0001), whereas cytoplasmic staining had no prognostic significance. Two hundred thirty-two patients (26.1%) received no additional treatment after surgery. The difference in survival rates between cases with positive and negative staining was only significant among patients submitted to adjuvant chemotherapy or hormone therapy. CONCLUSIONS:This study strongly supports the association of HER-2/neu oncoprotein expression with poor prognosis in node-positive breast cancer and demonstrates that membranous but not cytoplasmic staining is prognostically relevant. It also shows that HER-2/neu oncoprotein expression is useful in predicting survival time only in patients receiving adjuvant therapy, thus suggesting that it may be a marker of drug resistance.
journal_name
Cancerjournal_title
Cancerauthors
Têtu B,Brisson Jdoi
10.1002/1097-0142(19940501)73:9<2359::aid-cncr2820subject
Has Abstractpub_date
1994-05-01 00:00:00pages
2359-65issue
9eissn
0008-543Xissn
1097-0142journal_volume
73pub_type
杂志文章,多中心研究相关文献
CANCER文献大全abstract::Quality indicators applicable to cancer end-of-life care exist, but have not been widely implemented. To advance this field, the authors worked with the Agency for Health Care Research and Quality and the National Cancer Institute to organize a national symposium to discuss key issues and future goals, based on a conc...
journal_title:Cancer
pub_type:
doi:10.1002/cncr.24439
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Melanoma is the most lethal form of skin cancer, with an estimated 68,130 new cases and 8700 deaths in the United States in 2010. The increasing incidence and high death rate associated with metastatic disease support the need to focus on prevention. The authors used data from the Women's Health Initiative (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27497
更新日期:2012-10-15 00:00:00
abstract::Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891201)64:11<2279::aid-cncr282
更新日期:1989-12-01 00:00:00
abstract::The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<353::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::Because of the rarity of the primary carcinoma of the female urethra, there has been limited experience of individual institutions in management of this disease. Treatment by radiation alone required radium implant skill in early cases and individualized consideration for integrating external and internal irradiation ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197809)42:3<1177::aid-cncr282042
更新日期:1978-09-01 00:00:00
abstract::Data from 133 patients with cancer and suspected compression of the spinal cord or cauda equina was reviewed. Although there were differences in presenting symptoms and signs between the group of 62 patients with compression and the 71 without, no single symptom or sign discriminated adequately between the two groups....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1953::aid-cncr282
更新日期:1983-05-15 00:00:00
abstract::A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1519::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::Intravenous immunoglobulin (IVIG) has several potential uses in bone marrow transplantation. Most often IVIG is used to modify cytomegalovirus (CMV) infection or CMV-related interstitial pneumonia. It also is used to modify graft versus host disease (GVHD) and decrease infections other than CMV. Another use is to trea...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910915)68:6+<1451::aid-cncr282
更新日期:1991-09-15 00:00:00
abstract::Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830501)51:9<1750::aid-cncr2820
更新日期:1983-05-01 00:00:00
abstract::Grilled or fried meat and fish contain various mutagenic heterocyclic amines, and structures of at least 19 compounds have already been determined. Among these, 10 have been examined for long term carcinogenicity, all proving to be positive. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), for example, preferen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3+<1063::aid-cncr282
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The authors compared the relative efficacy and safety of low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) for the initial treatment of venous thromboembolism (VTE) between patients with and without cancer. METHODS:By using Cochrane methodology for systematic reviews, separate meta-analys...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23814
更新日期:2008-10-01 00:00:00
abstract::The incidence of breast cancer rose about 1% per year between 1940 and 1980 according to data in the Connecticut Tumor Registry. A sharp increase of 32% was reported between 1980 and 1987 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute. Data from this program shows that the i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820741304
更新日期:1994-07-01 00:00:00
abstract::Eighty-six children with non-Hodgkin's lymphoma were studied from 1964 to January 31, 1975. Seventy-six percent of the 43 patients in the nonprotocol group had far advanced disease, and 76% had Rappaport's diffuse histology. Only 11% of these patients survived free of disease. The second group of 43 patients received ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1<123::aid-cncr2820370
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Although outcomes for patients with squamous cell carcinoma of the anus (SCCA) have improved, the gains in benefit may not be shared uniformly among patients of disparate socioeconomic status. In the current study, the authors investigated whether area-based median household income (MHI) is predictive of sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31186
更新日期:2018-04-15 00:00:00
abstract::Thirty-one patients were treated with cisplatin combination chemotherapy for advanced seminoma (26 Stage III or bulky Stage II testicular, and five disseminated extragonadal). Seventeen (89%) of 19 patients not previously pretreated and four (80%) of five who had received only abdominal irradiation entered continuous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1625::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract::Wolfe has suggested that the mammographic parenchymal patterns can be used to identify a group with high incidence of breast cancer. To evaluate this claim, mammograms of women with breast cancer that was detected at the University of Michigan Breast Cancer Detection Demonstration Project have been classified and comp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800515)45:10<2550::aid-cncr282
更新日期:1980-05-15 00:00:00
abstract:BACKGROUND:Low socioeconomic status (SES) is a reported risk factor for cervical carcinoma, but few studies have taken into account adequately the possibly confounding effects of oncogenic human papillomavirus (HPV) infection as well as access to screening and subsequent treatment. METHODS:Women (n = 5060 women) with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21129
更新日期:2005-07-01 00:00:00
abstract::Two hundred-eighty patients were randomized to receive either BCNU, hydroxyurea and imidazole carboxamide (BHD), BHD plus levamisole, or high-dose DTIC plus actinomycin D. There was no difference in response rate in the three groups (24%, 25% and 22%). Females responded better than males and, as expected, those with a...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19840215)53:4<833::aid-cncr28205
更新日期:1984-02-15 00:00:00
abstract::This trial was conducted to determine if the reported superiority of tamoxifen (TAM) plus prednisolone (PRDLN) over TAM alone in postmenopausal women with metastatic breast cancer could be corroborated. A total of 326 patients were randomized on a double-blind trial to TAM (10 mg twice daily) plus placebo or TAM plus ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(19910701)68:1<34::aid-cncr282068
更新日期:1991-07-01 00:00:00
abstract::Clinicopathologic correlations were made in 50 patients with follicular large cell (FLC) lymphoma to better define the influence of a variety of clinical and pathologic features on survival and the potential for continuous freedom from disease. The 5- and 10-year actuarial survivals for the entire group of patients ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870415)59:8<1470::aid-cncr2820
更新日期:1987-04-15 00:00:00
abstract::An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850215)55:4<745::aid-cncr28205
更新日期:1985-02-15 00:00:00
abstract::Pancreatic carcinomas have been induced in Wistar and W/LEW rats by administration of total azaserine doses of 150-520 mg/kg by injection or oral routes over periods of 5-52 weeks. The latent period for development of invasive carcinomas was 1-2 years, but focal abnormalities in acinar cells appear earlier. The incide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6+<1562::aid-cncr282
更新日期:1981-03-15 00:00:00
abstract::The East Harlem Partnership for Cancer Awareness (EHPCA) was formed in 1999 to reduce disparities in cancer screening and prevention among medically underserved minorities residing in a large urban community (East Harlem, New York City) by increasing awareness of cancer risk, prevention, and treatment, and promoting g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22153
更新日期:2006-10-15 00:00:00
abstract:BACKGROUND:The focus on noncancer causes of death in patients with breast cancer (BC) remains superficial. The objective of the current study was to assess and quantify causes of death after BC diagnosis. METHODS:In total, 754,270 women with BC in the United States who were diagnosed during 2000 through 2015 and retri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32648
更新日期:2020-04-01 00:00:00
abstract::A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a fe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800915)46:6<1389::aid-cncr2820
更新日期:1980-09-15 00:00:00
abstract::Central nervous system (CNS) recurrence continues to be a significant complication in the treatment of adult patients with acute lymphoblastic leukemia (ALL). Preventing CNS recurrence has been a therapeutic challenge and has not been addressed critically in many clinical trials. Adult studies modeled on childhood ALL...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.25008
更新日期:2010-05-15 00:00:00
abstract::The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2291::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract::Eighty-seven previously untreated patients with pathologic Stage IA, II (A or B), or IIIA Hodgkin's disease were randomized over a 48-month period to receive either megavoltage extended field radiotherapy alone or megavoltage radiotherapy limited to involved lymph node sites (including at least an upper mantle field) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197504)35:4<1055::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract::The antitumor effect of human leukocyte interferon was investigated on ten patients with malignant brain tumor. In eight cases of primary tumor, IFN alone was administered when their recurrent sign was evident. A dose of 3 X 10(6) IU or 1 X 10(6) IU of IFN was injected intramuscularly two or three times a week in high...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<1976::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract::Patients with unresectable, previously untreated head and neck cancer were given cis-diamminedichloroplatinum (II) (DDP), 3 mg/kg, with mannitol diuresis (day 1), followed by a continuous infusion of bleomycin, 0.25 mg/kg/day, days 3 through 10, after an initial loading dose of 0.25 mg/kg by rapid IV injection on day ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<460::aid-cncr2820410
更新日期:1978-02-01 00:00:00