Metastatic ependymoma of the sacrum.


:Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a large intrasacral ependymoma with metastases to several vertebrae. Radiologic and pathologic studies are presented. Treatment options are discussed.






Miralbell R,Louis DN,O'Keeffe D,Rosenberg AE,Suit HD




Has Abstract


1990-05-15 00:00:00














  • Activity of 9-nitro-camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia.

    abstract:BACKGROUND:Topoisomerase I inhibitors, like topotecan, have activity in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). 9-Nitro-camptothecin (9-NC) is a new oral topoisomerase inhibitor with a good safety profile. The aims of the current study were to evaluate the activity and safety of 9-NC ...


    pub_type: 临床试验,杂志文章


    authors: Quintas-Cardama A,Kantarjian H,O'Brien S,Jabbour E,Giles F,Ravandi F,Faderl S,Pierce S,Shan J,Verstovsek S,Cortes J

    更新日期:2006-10-01 00:00:00

  • Clinical application of intratumoral blood flow study in patients with endometrial carcinoma.

    abstract:BACKGROUND:The objective of this study was to evaluate the correlation between intratumoral blood flow as assessed by color Doppler ultrasound with stage, tumor grade, depth of invasion, and lymph node metastasis in endometrial carcinoma and determine its clinical usefulness. METHODS:Sixty-six patients with endometria...


    pub_type: 临床试验,杂志文章


    authors: Cheng WF,Chen TM,Chen CA,Wu CC,Huang KT,Hsieh CY,Hsieh FJ

    更新日期:1998-05-15 00:00:00

  • Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy.

    abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...


    pub_type: 杂志文章,多中心研究


    authors: Têtu B,Brisson J

    更新日期:1994-05-01 00:00:00

  • External radiotherapy in thyroid cancers.

    abstract::Surgery is the most effective treatment for thyroid cancer; however, in some subsets of patients, the role of radiotherapy (RT) is important. The main indication for external-beam RT is incomplete surgery. When neoplastic tissue is left behind at operation, RT must be considered, but only if an experienced surgeon fee...


    pub_type: 杂志文章


    authors: Tubiana M,Haddad E,Schlumberger M,Hill C,Rougier P,Sarrazin D

    更新日期:1985-05-01 00:00:00

  • Conditional survival estimates improve over time for patients with advanced melanoma: results from a population-based analysis.

    abstract:BACKGROUND:Conditional survival (CS) has emerged as a clinically relevant measure of prognosis for cancer survivors. The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making. METHODS:Patients with melanoma and at least 5 years of foll...


    pub_type: 杂志文章


    authors: Xing Y,Chang GJ,Hu CY,Askew RL,Ross MI,Gershenwald JE,Lee JE,Mansfield PF,Lucci A,Cormier JN

    更新日期:2010-05-01 00:00:00

  • Treatment of advanced thyroid cancer with axitinib: Phase 2 study with pharmacokinetic/pharmacodynamic and quality-of-life assessments.

    abstract:BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...


    pub_type: 杂志文章,多中心研究


    authors: Locati LD,Licitra L,Agate L,Ou SH,Boucher A,Jarzab B,Qin S,Kane MA,Wirth LJ,Chen C,Kim S,Ingrosso A,Pithavala YK,Bycott P,Cohen EE

    更新日期:2014-09-01 00:00:00

  • Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study.

    abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...


    pub_type: 杂志文章


    authors: Howell CR,Wilson CL,Ehrhardt MJ,Partin RE,Kaste SC,Lanctot JQ,Pui CH,Robison LL,Hudson MM,Ness KK

    更新日期:2018-03-01 00:00:00

  • A scanning electron microscopy study of changes in the colonic mucus layer during chemical carcinogenesis.

    abstract::Scanning electron microscopy was used to examine the appearances of the colonic mucus layer of rats during chemical carcinogenesis with dimethylhydrazine. The normal colonic mucus layer had a dense homogeneous appearance and provided a complete cover for the mucosal epithelium. At high magnifications tiny fenestration...


    pub_type: 杂志文章


    authors: Traynor OJ,Costa NL,Wood CB

    更新日期:1983-05-15 00:00:00

  • Defining a molecular phenotype for benign and malignant parathyroid tumors.

    abstract:BACKGROUND:It is frequently difficult to establish histologically whether a parathyroid tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma. The authors asked whether these tumors have a distinctive molecular profile, whether benign tumors could be distinguished from malignant tumors, and whether...


    pub_type: 杂志文章


    authors: Fernandez-Ranvier GG,Khanafshar E,Tacha D,Wong M,Kebebew E,Duh QY,Clark OH

    更新日期:2009-01-15 00:00:00

  • Esophageal dilation in malignant dysphagia.

    abstract::Esophageal dilation by means of guided Neoplex (Medoc) tubes in 38 patients with malignant obstruction of the esophagus was analyzed. Peroral dilation proved to be a simple, well-tolerated primary procedure in the management of malignant strictures. Most patients have a temporary improvement of dysphagic symptoms, but...


    pub_type: 杂志文章


    authors: Aste H,Munizzi F,Martines H,Pugliese V

    更新日期:1985-12-01 00:00:00

  • Non-Hodgkin's lymphomas of stage III extent. Is total lymphoid irradiation appropriate treatment?

    abstract::Many investigators have regarded Stage III lymphomas as a generalized form of disease and have accordingly recommended systemic treatment programs. Between 1961 and 1973, 68 patients with clinical or pathologic Stage III non-Hodgkin's lymphomas were seen in the Division of Radiation Therapy at Stanford University Medi...


    pub_type: 杂志文章


    authors: Glatstein E,Fuks Z,Goffinet DR,Kaplan HS

    更新日期:1976-06-01 00:00:00

  • Mitomycin in metastatic breast cancer refractory to hormonal and combination chemotherapy.

    abstract::Forty-three patients with evaluable metastatic breast cancer refractory to hormonal agents and extensive combination chemotherapy including doxorubicin were treated with mitomycin, 20 mg/m2 intravenously every 6 weeks. There were five partial responses (12%) and three minor responses (7%), with a mean time to progress...


    pub_type: 杂志文章


    authors: Pasterz RB,Buzdar AU,Hortobagyi GN,Blumenschein GR

    更新日期:1985-11-15 00:00:00

  • Beta-benzene hexachloride in breast adipose tissue and risk of breast carcinoma.

    abstract:BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cas...


    pub_type: 杂志文章


    authors: Zheng T,Holford TR,Mayne ST,Owens PH,Ward B,Carter D,Dubrow R,Zahm SH,Boyle P,Tessari J

    更新日期:1999-05-15 00:00:00

  • Production of and response to interleukin-2 in peripheral blood lymphocytes of cancer patients.

    abstract::Interleukin-2 (IL2) is essential for the expansion of antigen-triggered lymphocytes and cytotoxic T-cells, processes necessary for tumor control that are frequently depressed in malignancy. The authors measured certain aspects of IL2 function in cancer patients and controls and correlated the findings with the general...


    pub_type: 杂志文章


    authors: Wanebo HJ,Pace R,Hargett S,Katz D,Sando J

    更新日期:1986-02-01 00:00:00

  • Presentation and outcome of frequent and rare sarcoma histologic subtypes: A study of 10,262 patients with localized visceral/soft tissue sarcoma managed in reference centers.

    abstract:BACKGROUND:The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODS:The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled...


    pub_type: 杂志文章,多中心研究


    authors: Penel N,Coindre JM,Giraud A,Terrier P,Ranchere-Vince D,Collin F,Guellec SLE,Bazille C,Lae M,de Pinieux G,Ray-Coquard IL,Bonvalot S,Cesne ALE,Robin YM,Stoeckle E,Toulmonde M,Blay JY

    更新日期:2018-03-15 00:00:00

  • Detection of human papillomavirus in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographic locations. In the current study, neoplasms from two separate geographic regions were analyzed for the presence of HPV DNA: METHODS:One hundred and ten esoph...


    pub_type: 杂志文章


    authors: Suzuk L,Noffsinger AE,Hui YZ,Fenoglio-Preiser CM

    更新日期:1996-08-15 00:00:00

  • Retroperitoneal lymphadenectomy and aggressive chemotherapy in nonbulky clinical Stage II nonseminomatous germinal testis tumors.

    abstract::In a former series of 60 resected Stage II nonseminomatous germinal testis tumors the authors succeeded in demonstrating that adjuvant cisplatin, vinblastine, and bleomycin (PVB) was able to significantly improve survival (100% in 11 treated versus 28.5% in 7 historical controls, P less than 0.01) only in patients wit...


    pub_type: 杂志文章


    authors: Pizzocaro G,Zanoni F,Milani A,Piva L,Salvioni R,Pasi M,Pilotti S,Monfardini S

    更新日期:1984-03-15 00:00:00

  • High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation.

    abstract:BACKGROUND:Recombinant tumor necrosis factor-alpha (rTNF-alpha) is a highly potential antineoplastic agent. However, its systemic administration in humans has resulted in a life-threatening septic shock-like syndrome, and its use has been abandoned. The administration of high dose rTNF-alpha and melphalan via isolated ...


    pub_type: 杂志文章


    authors: Gutman M,Inbar M,Lev-Shlush D,Abu-Abid S,Mozes M,Chaitchik S,Meller I,Klausner JM

    更新日期:1997-03-15 00:00:00

  • Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh.

    abstract:BACKGROUND:The authors sought to determine whether differences existed in patterns of outcome and morbidity between the 3 thigh compartments after limb-sparing surgery and postoperative radiation therapy (RT). METHODS:A total of 255 patients with primary soft tissue sarcoma (STS) of the thigh were identified in our sa...


    pub_type: 杂志文章


    authors: Rimner A,Brennan MF,Zhang Z,Singer S,Alektiar KM

    更新日期:2009-01-01 00:00:00

  • Adjuvant 5-fluorouracil plus doxorubicin in D2-3 resected gastric carcinoma: 15-year experience at a single institute.

    abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...


    pub_type: 临床试验,杂志文章


    authors: Jeung HC,Rha SY,Noh SH,Min JS,Kim BS,Chung HC

    更新日期:2001-06-01 00:00:00

  • Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.

    abstract:BACKGROUND:In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. METHODS:The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (...


    pub_type: 杂志文章


    authors: Donin N,Filson C,Drakaki A,Tan HJ,Castillo A,Kwan L,Litwin M,Chamie K

    更新日期:2016-10-01 00:00:00

  • Association of the -160 C --> a promoter polymorphism of E-cadherin gene with gastric carcinoma risk.

    abstract:BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...


    pub_type: 杂志文章


    authors: Wu MS,Huang SP,Chang YT,Lin MT,Shun CT,Chang MC,Wang HP,Chen CJ,Lin JT

    更新日期:2002-03-01 00:00:00

  • Reticulum cell sarcomas (large cell lymphomas) presenting in the skin. High frequency of true histiocytic lymphoma.

    abstract::The clinical and histologic data from 12 patients with "reticulum cell sarcoma" (large cell lymphoma) presenting in the skin were reviewed. Moreover, when appropriate material was available additional immunological, cytochemical and ultrastructural techniques were used to define the nature of the neoplastic cells. Eig...


    pub_type: 杂志文章


    authors: Willemze R,Ruiter DJ,Van Vloten WA,Meijer CJ

    更新日期:1982-10-01 00:00:00

  • Cisplatin and 5-fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin.

    abstract::Seven patients with advanced locoregional or metastatic squamous cell carcinoma of the skin were treated with cis-daimminedichloroplatin (cisplatin) and 5-fluorouracil (5-FU). Responses were seen in six of seven patients (three partial responses [PR] and three complete responses [CR]). One patient is alive and disease...


    pub_type: 临床试验,杂志文章


    authors: Khansur T,Kennedy A

    更新日期:1991-04-15 00:00:00

  • Carcinoma of the pancreas: review of MGH experience from 1963 to 1973. Analysis of surgical failure and implications for radiation therapy.

    abstract::A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...


    pub_type: 杂志文章


    authors: Tepper J,Nardi G,Sutt H

    更新日期:1976-03-01 00:00:00

  • Chemotherapy of disseminated breast cancer. Current status and prospects.

    abstract::Chemotherapy once relegated to end stage patients has markedly improved with the use of combinations. Response rates with single agents have improved from 15 to 35%, to 50 to 70%, using combinations with an increase in complete response rates to about 25%. A series of four studies completed by the Eastern Cooperative ...


    pub_type: 临床试验,杂志文章


    authors: Carbone PP,Bauer M,Band P,Tormey D

    更新日期:1977-06-01 00:00:00

  • Cancer screening and aging: research barriers and opportunities.

    abstract::Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...


    pub_type: 杂志文章,评审


    authors: Sheinfeld Gorin S,Gauthier J,Hay J,Miles A,Wardle J

    更新日期:2008-12-15 00:00:00

  • Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on Yoshida sarcoma-bearing rats.

    abstract::Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...


    pub_type: 杂志文章


    authors: Goseki N,Yamazaki S,Endo M,Onodera T,Kosaki G,Hibino Y,Kuwahata T

    更新日期:1992-04-01 00:00:00

  • Clinical characteristics of 45 patients with invasive pulmonary aspergillosis: retrospective analysis of 1711 lung cancer cases.

    abstract:BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...


    pub_type: 杂志文章


    authors: Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Y

    更新日期:2009-11-01 00:00:00

  • Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature.

    abstract::Chondrosarcoma of the temporal bone is a rare lesion. Clinically it has been confused with multiple sclerosis, glomus jugulare tumors, meningioma, and chordomas. The cranial nerve palsies frequently observed with the tumors are related to the anatomic locations of the tumors. Thirteen patients with this entity are pre...


    pub_type: 杂志文章


    authors: Coltrera MD,Googe PB,Harrist TJ,Hyams VJ,Schiller AL,Goodman ML

    更新日期:1986-12-15 00:00:00