Abstract:
:The prognostic value of nuclear DNA content was studied retrospectively using flow cytometry in 203 cases of resected hepatocellular carcinoma. The occurrence of DNA aneuploidy, which was detected in 50% of patients, correlated significantly with tumor size and the presence of vascular invasion or intrahepatic metastasis. Overall, patients with DNA aneuploid tumors had a significantly worse prognosis than those with DNA diploid tumors (P less than 0.001) and, also in subdivided groups by tumor size (P less than 0.01). Among DNA aneuploid patients, the survival times were significantly shorter for patients with a low DNA index (less than 1.5) than for those with a high DNA index (greater than or equal to 1.5) (P less than 0.05). In a Cox multivariate analysis, nuclear DNA content provided significant prognostic value (P = 0.008), as did vascular invasion (P = 0.001) and intrahepatic metastasis (P = 0.005). These results indicated that nuclear DNA content has an important prognostic value in hepatocellular carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
Fujimoto J,Okamoto E,Yamanaka N,Toyosaka A,Mitsunobu Mdoi
10.1002/1097-0142(19910215)67:4<939::aid-cncr28206subject
Has Abstractpub_date
1991-02-15 00:00:00pages
939-44issue
4eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
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