Splenic alterations in hairy-cell leukemia: II. an electron microscopic study.

abstract：BACKGROUND:The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS:Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 ...

journal_title：Cancer

authors： Momm F,Kaden M,Tannock I,Schumacher M,Hasse J,Henke M

更新日期：2010-10-15 00:00:00

abstract：:The mechanisms of biochemical modulation of 5-fluorouracil (5-FU) cytotoxicity by folinic acid (FA) have been elucidated, and the clinical use of this combination has improved response rates and survival in patients with metastatic colorectal cancer. Recently, Phase II trials also showed potential synergism between al...

journal_title：Cancer

authors： Bukowski RM,Inoshita G,Yalavarthi P,Murthy S,Gibson V,Budd GT,Sergi JS,Bauer L,Prestifilippo J

更新日期：1992-02-15 00:00:00

abstract：BACKGROUND:It is unclear whether patients with Stage II colon carcinoma should be offered adjuvant chemotherapy. Therefore, the authors analyzed the risk factors of these patients to identify high-risk subgroups who may benefit from such treatment. METHODS:The data from 305 patients with Stage II colon carcinoma docum...

journal_title：Cancer

authors： Merkel S,Wein A,Günther K,Papadopoulos T,Hohenberger W,Hermanek P

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:Clinical trials established the value of breast-conserving treatment (BCT) including the macroscopic removal of the tumor followed by local radiation therapy (RT) for Stage I and II invasive carcinomas. The occurrence of local tumor recurrence is related to the extent and multifocality of the tumor. Various ...

journal_title：Cancer

authors： Faverly DR,Hendriks JH,Holland R

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...

journal_title：Cancer

authors： Akcakanat A,Sahin A,Shaye AN,Velasco MA,Meric-Bernstam F

更新日期：2008-06-01 00:00:00

abstract：:The development of drug resistance limits the survival or patients with small cell anaplastic carcinoma of the lung (SCLC). The present study was undertaken to overcome this problem by administering two alternating noncross resistant combination chemotherapy regimens. One-hundred-one patients were entered on study, an...

journal_title：Cancer

authors： Aroney RS,Bell DR,Chan WK,Dalley DN,Levi JA

更新日期：1982-06-15 00:00:00

abstract：BACKGROUND:Tamoxifen has been used in the treatment of patients with metastatic malignant melanoma either as a single agent or, more commonly, in combination with other chemotherapeutic agents. The aim of the current study was to summarize the available clinical evidence on the role of the tamoxifen in different combin...

journal_title：Cancer

authors： Lens MB,Reiman T,Husain AF

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Current techniques to define gastric neoplasia are limited but molecular genetic signatures can categorize tumors and provide biological rationale for predicting clinical behavior. We identified three gene signatures: Chromogranin A (CgA), MAGE-D2 (adhesion), and MTA1 (metastasis) that define gastrointestina...

journal_title：Cancer

authors： Kidd M,Modlin IM,Mane SM,Camp RL,Eick GN,Latich I,Zikusoka MN

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤ 60 years old. METHODS:Between August 2006 and January 2010, 262 hormone-naive men ≤ 60 years old were treated with definitive proton therapy for prostate cancer. Before treatme...

journal_title：Cancer

authors： Hoppe BS,Nichols RC,Henderson RH,Morris CG,Williams CR,Costa J,Marcus RB Jr,Mendenhall WM,Li Z,Mendenhall NP

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:The incidence, risk factors, time course, and impact on survival of venous thromboembolism (VTE) in a large, population-based study of patients with bladder cancer have not been identified previously. METHODS:The California Cancer Registry was merged with the California Patient Discharge Data Set to determi...

journal_title：Cancer

authors： Sandhu R,Pan CX,Wun T,Harvey D,Zhou H,White RH,Chew HK

更新日期：2010-06-01 00:00:00

abstract：:Twenty-two patients who previously responded to first-line hormonal therapy were evaluated for factors which would predict for response to second hormonal manipulation. Investigations performed at progression after initial hormone response included immunocytochemical estimation of estrogen and progesterone receptors a...

journal_title：Cancer

authors： Seymour L,Bezwoda WR,Meyer K

更新日期：1990-06-15 00:00:00

abstract：BACKGROUND:In this study, the authors evaluated the clinical presentation of patients with T4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the T4 tumor category still has any justification. METHODS:The clinical course of a study gr...

journal_title：Cancer

authors： Guth U,Wight E,Schotzau A,Langer I,Dieterich H,Rochlitz C,Herberich L,Holzgreve W,Singer G

更新日期：2005-11-01 00:00:00

abstract：:Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...

journal_title：Cancer

authors： Steensma DP,Brunner AM,DeZern AE,Garcia-Manero G,Komrokji RS,Odenike OS,Roboz GJ,Savona MR,Stone RM,Sekeres MA

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...

journal_title：Cancer

authors： Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

更新日期：1993-01-01 00:00:00

abstract：:The prognostic significance of histologic tumor grade has been evaluated in 1537 women entered into the Ludwig Trials I-IV of adjuvant therapy for node-positive breast cancer. Tumor grade was determined on histologic review of primary tumor sections by two central review pathologists using a modification of the Bloom ...

journal_title：Cancer

authors： Davis BW,Gelber RD,Goldhirsch A,Hartmann WH,Locher GW,Reed R,Golouh R,Säve-Söderbergh J,Holloway L,Russell I

更新日期：1986-12-15 00:00:00

abstract：BACKGROUND:Constitutional or somatic mosaic epimutations are increasingly recognized as a mechanism of gene dysregulation resulting in cancer susceptibility. Beckwith-Wiedemann syndrome is the cancer predisposition syndrome most commonly associated with epimutation and is extremely variable in its phenotypic presentati...

journal_title：Cancer

authors： Fiala EM,Ortiz MV,Kennedy JA,Glodzik D,Fleischut MH,Duffy KA,Hathaway ER,Heaton T,Gerstle JT,Steinherz P,Shukla N,McNeer N,Tkachuk K,Bouvier N,Cadoo K,Carlo MI,Latham A,Dubard Gault M,Joseph V,Kemel Y,Kentsis A,

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Patient navigation programs are emerging that aim to address disparities in clinical trial participation among medically underserved populations, including racial/ethnic minorities. However, there is a lack of consensus on the role of patient navigators within the clinical trial process as well as outcome me...

journal_title：Cancer

authors： Ghebre RG,Jones LA,Wenzel JA,Martin MY,Durant RW,Ford JG

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...

journal_title：Cancer

authors： Garrison LP Jr,Lalla D,Brammer M,Babigumira JB,Wang B,Perez EA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Methotrexate is a chemotherapeutic agent frequently utilized for the treatment of malignant, rheumatic, and pulmonary diseases. Although this agent has been extensively used for more than 45 years, there are few reports of immediate systemic hypersensitivity reactions. The reported immediate reactions includ...

journal_title：Cancer

authors： Alkins SA,Byrd JC,Morgan SK,Ward FT,Weiss RB

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of o...

journal_title：Cancer

authors： Thomas DG,Giordano TJ,Sanders D,Biermann S,Sondak VK,Trent JC,Yu D,Pollock RE,Baker L

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chemotherapy, more recent...

journal_title：Cancer

authors： Wefel JS,Vidrine DJ,Veramonti TL,Meyers CA,Marani SK,Hoekstra HJ,Hoekstra-Weebers JE,Shahani L,Gritz ER

更新日期：2011-01-01 00:00:00

abstract：:In order to validate xenografted small cell lung carcinomas (SCLC) for biological studies, the authors established 12 lung neuroendocrine (NE) tumors (eight typical SCLC and four atypical NE tumors [ANE]) by heterotransplantation onto nude mice. Their characterization was performed using serial ultrastructural, enzyma...

journal_title：Cancer

authors： Brambilla E,Jacrot M,Batandier C,Brichon PY,Morel F,Nagy-Mignotte H,Paramelle B,Brambilla C

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:As a result of a major social and demographic transition, Colombia is currently undergoing major changes in disease-specific mortality rates, including an increasing burden of cancer death. The current article described some aspects of the evolution of cancer mortality in Colombia and, in particular, highlig...

journal_title：Cancer

authors： Piñeros M,Hernández G,Bray F

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cause of cancer deaths; however, rates of regular screening for this cancer are low. A quality improvement (QI) program to increase CRC screening was developed for use in a managed care health plan. METHODS:Thirty-six provider organizations (POs) contracting ...

journal_title：Cancer

authors： Ganz PA,Farmer MM,Belman MJ,Garcia CA,Streja L,Dietrich AJ,Winchell C,Bastani R,Kahn KL

更新日期：2005-11-15 00:00:00

abstract：:Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II--IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone...

journal_title：Cancer

authors： Brereton HD,Young RC,Longo DL,Kirkland LR,Berard CW,Jaffe ES,DeVita VT,Johnson RE

更新日期：1979-06-01 00:00:00

abstract：:Seventy three patients with disseminated diffuse non-Hodgkin's lymphomas were treated with combinations of cyclophosphamide, vincristine sulfate, prednisone, and doxorubicin with and without 2 weekly doses of oral methotrexate in "intermediate" doses, followed by calcium leucovorin rescue. The addition of methotrexate...

journal_title：Cancer

authors： Gomez GA,Barcos M,Han T,Henderson ES

更新日期：1987-07-01 00:00:00

abstract：:Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure g...

journal_title：Cancer

authors： Voigtmann R,Pokorny J,Meinshausen A

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) develops through the alteration of several critical pathways. This study was aimed at evaluating the influence of critical pathways on survival outcomes for patients with CRC. METHODS:Targeted next-generation sequencing of 40 genes included in the 5 critical pathways of CRC (WNT, P53...

journal_title：Cancer

authors： Lee DW,Han SW,Cha Y,Bae JM,Kim HP,Lyu J,Han H,Kim H,Jang H,Bang D,Huh I,Park T,Won JK,Jeong SY,Park KJ,Kang GH,Kim TY

更新日期：2017-09-15 00:00:00

abstract：:A broad ligament tumor with the histologic features of a female adnexal tumor of probable Wolffian origin, as described by Kariminejad and Scully, is reported. Although previous cases were thought to be benign, in the present case, hepatic metastasis occurred 6 years after resection of the primary. Cytologic features ...

journal_title：Cancer

authors： Taxy JB,Battifora H

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Crizotinib is a tyrosine kinase inhibitor active against ALK, MET, and ROS1. We previously reported that crizotinib decreases testosterone in male patients. The detailed etiology of the effect, its symptomatic significance, and the effectiveness of subsequent testosterone replacement have not been previously...

journal_title：Cancer

authors： Weickhardt AJ,Doebele RC,Purcell WT,Bunn PA,Oton AB,Rothman MS,Wierman ME,Mok T,Popat S,Bauman J,Nieva J,Novello S,Ou SH,Camidge DR

更新日期：2013-07-01 00:00:00