Abstract:
:Seventy three patients with disseminated diffuse non-Hodgkin's lymphomas were treated with combinations of cyclophosphamide, vincristine sulfate, prednisone, and doxorubicin with and without 2 weekly doses of oral methotrexate in "intermediate" doses, followed by calcium leucovorin rescue. The addition of methotrexate did not increase the complete remission rate, the remission duration, or the survival (P value = 1.0, 0.74, and 0.78, respectively) in patients who did not have previous chemotherapy treatment. In previously treated patients, the complete remission rate was somewhat higher and the remission duration and survival were longer among those patients treated with the methotrexate containing program; however these differences were not statistically significant (P values = 0.88, 0.81, and 0.46, respectively). There was substantial morbidity and mortality during treatment with both treatment arms, among patients aged more than 60 years.
journal_name
Cancerjournal_title
Cancerauthors
Gomez GA,Barcos M,Han T,Henderson ESdoi
10.1002/1097-0142(19870701)60:1<18::aid-cncr282060subject
Has Abstractpub_date
1987-07-01 00:00:00pages
18-24issue
1eissn
0008-543Xissn
1097-0142journal_volume
60pub_type
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