Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.

Abstract:

:A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologic markers specific for other cell lineages, and germ line configuration of the immunoglobulin light chain gene and the T-cell receptor beta-chain gene. Its neoplastic nature was suggested by the single rearranged band of the immunoglobulin heavy chain gene.

journal_name

Cancer

journal_title

Cancer

authors

Kamesaki H,Koya M,Miwa H,Kita K,Doi S,Tatsumi E,Hatanaka M,Uchino H

doi

10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

1306-9

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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