Preclinical and clinical studies of interferons and interferon inducers in breast cancer.

abstract：BACKGROUND:: Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third-generation agents (gemcitabine [G], vinorelbine, ...

journal_title：Cancer

authors： Russo A,Rizzo S,Fulfaro F,Adamo V,Santini D,Vincenzi B,Gebbia N,Carreca I

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)-negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow-up study has been performed...

journal_title：Cancer

authors： Squadrito G,Pollicino T,Cacciola I,Caccamo G,Villari D,La Masa T,Restuccia T,Cucinotta E,Scisca C,Magazzu D,Raimondo G

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:Because angiogenesis may play a role in the pathogenesis of acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS), and thalidomide (Th) has shown significant anti-angiogenic activity, this study was designed to investigate the potential role of Th in the treatment of patients with AML and...

journal_title：Cancer

authors： Cortes J,Kantarjian H,Albitar M,Thomas D,Faderl S,Koller C,Garcia-Manero G,Giles F,Andreeff M,O'Brien S,Keating M,Estey E

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well as the surgical approach to pediatric and adolescent renal cell carcinoma (pRCC). METHODS:pRCC cases prospectively enrolled on the Children's Oncology Group study AREN03B2 underwent central path...

journal_title：Cancer

authors： Geller JI,Ehrlich PF,Cost NG,Khanna G,Mullen EA,Gratias EJ,Naranjo A,Dome JS,Perlman EJ

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Sperm cryopreservation before cancer chemotherapy is available for young patients with cancer. However, few patients bank their sperm. The authors evaluated by questionnaire the psychological impact of sperm cryopreservation. METHODS:The authors cryopreserved the sperm of 111 patients with cancer for free a...

journal_title：Cancer

authors： Saito K,Suzuki K,Iwasaki A,Yumura Y,Kubota Y

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically re...

journal_title：Cancer

authors： Clarke LE,Flake DD 2nd,Busam K,Cockerell C,Helm K,McNiff J,Reed J,Tschen J,Kim J,Barnhill R,Elenitsas R,Prieto VG,Nelson J,Kimbrell H,Kolquist KA,Brown KL,Warf MB,Roa BB,Wenstrup RJ

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:The purpose of the study was to determine the utility of quantitation of the extracellular domain (ECD) of the HER-2/neu receptor in the serum for predicting response to treatment in patients with primary breast cancer receiving neoadjuvant therapy. METHODS:HER-2/neu ECD was measured in sera obtained from 3...

journal_title：Cancer

authors： Mazouni C,Hall A,Broglio K,Fritsche H,Andre F,Esteva FJ,Hortobagyi GN,Buzdar AU,Pusztai L,Cristofanilli M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...

journal_title：Cancer

authors： Perez EA,Barrios C,Eiermann W,Toi M,Im YH,Conte P,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Petersen JA,De Haas S,Hoersch S,Patre M,Ellis PA

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:PC-SPES is an herbal supplement whose mechanisms of action are poorly understood, but may be estrogenic. The objective of the current report is to describe the effects of discontinuing PC-SPES treatment in four patients with androgen-independent prostate carcinoma. METHODS:Patient charts were retrospectivel...

journal_title：Cancer

authors： Oh WK,George DJ,Kantoff PW

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed a...

journal_title：Cancer

authors： Spring PM,Valentino J,Arnold SM,Sloan D,Kenady D,Kudrimoti M,Haydon RC 3rd,Lee C,Given C,Mohiuddin M,Regine WF

更新日期：2005-10-15 00:00:00

abstract：:This report describes a unique palliative approach of radical surgical debridement for uncontrollable, recurrent pelvic tumors ulcerating through the perineum. All conservative treatment attempts with radiotherapy and chemotherapy had failed. Seven patients have been treated with resection of the tumor including a por...

journal_title：Cancer

authors： Temple WJ,Ketcham AS

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Childhood cancer survivors have been reported to be vulnerable to psychiatric morbidities and risky health behavior. Suicides, substance abuse, accidents, and violence as causes of death can be regarded as an extreme manifestation of risky health behavior. In the current study, the authors studied the risk o...

journal_title：Cancer

authors： Korhonen LM,Taskinen M,Rantanen M,Erdmann F,Winther JF,Bautz A,Feychting M,Mogensen H,Talbäck M,Malila N,Ryynänen H,Madanat-Harjuoja L

更新日期：2019-10-15 00:00:00

abstract：:This paper reports the prognosis results of a retrospective study of over 2000 cases of uterine cervix carcinoma totally treated at Institut Gustave-Roussy from 1950 to 1963. From the study of their long-term survival, an overall cure rate was estimated at 49% seven years after the start of primary treatment. A study ...

journal_title：Cancer

authors： Pejovic MH,Wolff JP,Kramar A,Goldfarb E

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Prostatic cancer is an unusual malignancy because, commonly, it is slowly progressive and occurs at an age where the patient's life expectancy is short as a result of considerable competing mortality rates from other diseases. In addition, the place of radical surgery, i.e., radical prostatectomy is still no...

journal_title：Cancer

authors： Smith PH,Parmar MK

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Some vasoactive drugs have been studied in the hope of altering the vascular permeability and/or blood of tumors to enhance monoclonal antibody (MoAb) uptake. The pretreatment of interleukin-2 (IL-2), one of the vasoactive reagents, produced a generalized vascular permeability, but its function was not tumor...

journal_title：Cancer

authors： Nakamura K,Kubo A

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Despite recent advances in diagnosis and treatment, gastric carcinoma remains a major cause of death in the world. METHODS:The clinicopathologic profile of 10,000 consecutive patients who underwent primary gastrectomy during 1962-1989 were reviewed and prognostic factors influencing survival in those with g...

journal_title：Cancer

authors： Nakamura K,Ueyama T,Yao T,Xuan ZX,Ambe K,Adachi Y,Yakeishi Y,Matsukuma A,Enjoji M

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:External beam radiation therapy (EBRT) for rectal cancer unavoidably delivers significant radiation dose to the prostate gland. The effect of this incidental exposure on subsequent prostate cancer diagnosis was investigated using the Surveillance, Epidemiology, and End Results (SEER) cancer registry. METHOD...

journal_title：Cancer

authors： Hoffman KE,Hong TS,Zietman AL,Russell AH

更新日期：2008-02-15 00:00:00

abstract：:Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...

journal_title：Cancer

authors： Wagner HN Jr,Conti PS

更新日期：1991-02-15 00:00:00

abstract：BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...

journal_title：Cancer

authors： Garcia-Carbonero R,Paz-Ares L,Arcediano A,Lahuerta J,Bartolome A,Cortes-Funes H

更新日期：1998-08-01 00:00:00

abstract：:Initial biopsy and resection specimens from 78 cerebral astrocytomas with anaplastic foci occurring in adults were examined for the presence of five specific histologic features traditionally considered indicative of anaplasia. Anaplastic astrocytomas with foci of tumor necrosis had been classified as glioblastoma mul...

journal_title：Cancer

authors： Fulling KH,Garcia DM

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...

journal_title：Cancer

authors： Campanella C,Rappa F,Sciumè C,Marino Gammazza A,Barone R,Bucchieri F,David S,Curcurù G,Caruso Bavisotto C,Pitruzzella A,Geraci G,Modica G,Farina F,Zummo G,Fais S,Conway de Macario E,Macario AJ,Cappello F

更新日期：2015-09-15 00:00:00

abstract：:C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effe...

journal_title：Cancer

authors： Lundy J,Lovett EJ 3rd,Hamilton S,Conran P

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:Patients with bulky laryngopharyngeal masses and a relative or absolute contraindication to general anesthesia present diagnostic difficulties. In the current study, the authors assessed the utility of transcutaneous ultrasound-guided Tru-Cut biopsy (USGTCB) under local anesthesia in such individuals. METHO...

journal_title：Cancer

authors： Ansarin M,De Fiori E,Preda L,Maffini F,Bruschini R,Calabrese L,Jereczek-Fossa BA,Chiesa F,Bellomi M

更新日期：2007-06-01 00:00:00

abstract：:One hundred two long-term survivors of childhood cancers with second malignant neoplasms (SMNs) were collected from 10 institutions. Forty-seven cases fulfilling study criteria were studied to determine the risk of developing a SMN in irradiated fields after exposure to various chemotherapeutic agents. The case contro...

journal_title：Cancer

authors： D'Angio GJ,Meadows A,Miké V,Harris C,Evans A,Jaffe N,Newton W,Schweisguth O,Sutow W,Morris-Jones P

更新日期：1976-02-01 00:00:00

abstract：:"Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. The case of a 54-year-old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. The patient was sensitized to dinitrochlorobenzene ...

journal_title：Cancer

authors： Raaf JH,Krown SE,Pinsky CM,Cunningham-Rundles W,Safai B,Oettgen HF

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:As we approach the 21st century, clinically useful predictive models for prostate carcinoma are urgently needed to stratify patients reliably for future treatment strategies. Recently, many investigators have developed models that employ prostate specific antigen (PSA)-based constructs or groupings in an att...

journal_title：Cancer

authors： Movsas B,Hanlon AL,Teshima T,Hanks GE

更新日期：1997-09-15 00:00:00

abstract：:A 55-year-old man is reported who initially developed chronic lymphocytic leukemia. Seven years later, after chemotherapy with chlorambucil, chronic myelogenous leukemia was diagnosed in addition to the chronic lymphocytic leukemia. Four previously reported cases with the same sequence of events are reviewed as well a...

journal_title：Cancer

authors： Schreiber ZA,Axelrod MR,Abebe LS

更新日期：1984-08-15 00:00:00

abstract：BACKGROUND:In this report, the authors describe their collective experience with melphalan-based autotransplants since the inception of their program at the University of Arkansas for Medical Sciences in 1989. METHODS:The authors evaluated the clinical outcomes of 3077 successive patients with multiple myeloma (MM) wh...

journal_title：Cancer

authors： Pineda-Roman M,Barlogie B,Anaissie E,Zangari M,Bolejack V,van Rhee F,Tricot G,Crowley J

更新日期：2008-04-15 00:00:00

abstract：:A case is presented of a man with ulcerating skin nodules who was diagnosed by histologic and immunohistologic analysis of skin biopsy specimens as having lymphomatoid granulomatosis (LYG). Phenotypic studies showed the majority of the infiltrating cells to be activated CD4+ T-lymphocytes. The disease followed a rapid...

journal_title：Cancer

authors： Atkinson CH,Davis AL,Colls BM,Wolever TH,Burry AF,Hart DN

更新日期：1989-02-15 00:00:00

abstract：:A Chinese patient with documented hepatocellular carcinoma (HCC) satisfied the criteria of Everson and Cole for spontaneous regression of malignant tumors. Subsequently he survived a tumor-free period of at least 13 years. During the period of regression, shrinkage of liver coincided with a rise of SGOT to a level com...

journal_title：Cancer

authors： Lam KC,Ho JC,Yeung RT

更新日期：1982-07-15 00:00:00