Abstract:
:Initial biopsy and resection specimens from 78 cerebral astrocytomas with anaplastic foci occurring in adults were examined for the presence of five specific histologic features traditionally considered indicative of anaplasia. Anaplastic astrocytomas with foci of tumor necrosis had been classified as glioblastoma multiforme and excluded from this analysis. Median actuarial survival was shorter for patients whose tumors contained vascular endothelial proliferation (3.5 years versus 5.5 years) or greater than 1 mitosis per 10 high power microscopic fields (1 year versus 5.5 years). No correlation with survival was found for estimation of nuclear pleomorphism and cell density or the presence of secondary structures. Vascular endothelial proliferation and increased mitotic activity may serve as prognostically significant histologic markers in cerebral astrocytomas of intermediate malignancy.
journal_name
Cancerjournal_title
Cancerauthors
Fulling KH,Garcia DMdoi
10.1002/1097-0142(19850301)55:5<928::aid-cncr28205subject
Has Abstractpub_date
1985-03-01 00:00:00pages
928-31issue
5eissn
0008-543Xissn
1097-0142journal_volume
55pub_type
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