Abstract:
:Four patients with benign giant cell tumor and one patient with probable benign giant cell tumor associated with Paget's disease of bone are reported. The familial and geographic clustering of these cases is unique in that three patients were related and all patients traced ancestral roots to the same area of southern Italy. Tumors arose from the cranial or facial bones in three patients and from vertebral bodies in two patients. All caused symptoms by local compression, and treatment by curettage or radiotherapy was successful in all patients. Three separate tumors in one patient shrank dramatically in response to treatment with high doses of dexamethasone, and one patient whose tumor caused spinal cord compression showed marked improvement in neurologic function on therapy with dexamathasone.
journal_name
Cancerjournal_title
Cancerauthors
Jacobs TP,Michelsen J,Polay JS,D'Adamo AC,Canfield REdoi
10.1002/1097-0142(197908)44:2<742::aid-cncr2820440subject
Has Abstractpub_date
1979-08-01 00:00:00pages
742-7issue
2eissn
0008-543Xissn
1097-0142journal_volume
44pub_type
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