Abstract:
:The authors investigated the ability of androgen receptor binding in prostate cancer tissue to predict the response of prostate cancer patients to endocrine therapy. The clinical response of 37 previously untreated patients with various grades and stages of prostate cancer was correlated with androgen receptor binding and detailed histologic data obtained before treatment. All patients underwent cold-punch transurethral resection of the prostate and received endocrine therapy. The association between time to progression and cytosolic androgen binding was not significant. However, the associations of time to progression to nuclear binding and to total androgen binding were significant (P = 0.029 and 0.038, respectively). The authors found no association between clinical stage and time to progression, but did find an association between time to progression and pathologic grade (P = 0.003); grade 4 lesions were the least responsive to hormone therapy. When grade 4 lesions were excluded (N = 3), binding levels were still predictive of progression independently of grade and stage. The authors conclude that nuclear receptor binding activity in localized and metastatic prostate cancer tissue is predictive of response to hormonal manipulation.
journal_name
Cancerjournal_title
Cancerauthors
Benson RC Jr,Gorman PA,O'Brien PC,Holicky EL,Veneziale CMdoi
10.1002/1097-0142(19870501)59:9<1599::aid-cncr2820subject
Has Abstractpub_date
1987-05-01 00:00:00pages
1599-606issue
9eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
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