Abstract:
:The fine structure of a pineal germinoma was studied in tissue blocks and in tissue culture. The original tumor contained large primary tumor cells, lymphocytes, macrophages, plasma cells, and astrocytes. The large primary tumor cells were characterized by large nuclei, relatively scanty organelles, abundant glycogen, and junctional complexes. The neoplasm grew well in vitro and, with the exception of plasma cells, contained the same cell types found in vivo. The ultrastructural characteristics of the cells in vivo and in vitro were similar. In culture there were few large primary tumor cells. Macrophages, often involved in active phagocytosis, were prominent in the original tumor and were the most common cell type found in vitro. A tumor-associated immune response is postulated in this neoplasm.
journal_name
Cancerjournal_title
Cancerauthors
Markesbery WR,Brooks WH,Milsow L,Mortara RHdoi
10.1002/1097-0142(197601)37:1<327::aid-cncr2820370subject
Has Abstractpub_date
1976-01-01 00:00:00pages
327-37issue
1eissn
0008-543Xissn
1097-0142journal_volume
37pub_type
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