Ultrastructural study of the pineal germinoma in vivo and in vitro.

Abstract:

:The fine structure of a pineal germinoma was studied in tissue blocks and in tissue culture. The original tumor contained large primary tumor cells, lymphocytes, macrophages, plasma cells, and astrocytes. The large primary tumor cells were characterized by large nuclei, relatively scanty organelles, abundant glycogen, and junctional complexes. The neoplasm grew well in vitro and, with the exception of plasma cells, contained the same cell types found in vivo. The ultrastructural characteristics of the cells in vivo and in vitro were similar. In culture there were few large primary tumor cells. Macrophages, often involved in active phagocytosis, were prominent in the original tumor and were the most common cell type found in vitro. A tumor-associated immune response is postulated in this neoplasm.

journal_name

Cancer

journal_title

Cancer

authors

Markesbery WR,Brooks WH,Milsow L,Mortara RH

doi

10.1002/1097-0142(197601)37:1<327::aid-cncr2820370

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

327-37

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

37

pub_type

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