Abstract:
:We measured des-gamma-carboxyglutamic acid prothrombin (protein induced by vitamin K absence or antagonist-Factor II: [PIVKA-II]) in plasmas of normal subjects, patients with thrombotic disease, those with hepatic disease including hepatocellular carcinoma, and those with carcinoma of other tissues, and compared the results with results of blood coagulation tests used for the examination of hepatic function. In addition, in the patients with hepatic disease, PIVKA-II and alpha-fetoprotein (AFP) levels were compared. The PIVKA-II level was frequently high in patients with thrombotic disease given warfarin therapy and those with hepatocellular carcinoma. However, in patients with thrombotic disease who were not given warfarin therapy, no significant correlation was seen between the PIVKA-II value and the results of the thrombotest or hepaplastin test, suggesting no association between the PIVKA-II level and the degree of impairment of hepatic function. In 70 patients with hepatocellular carcinoma, the percentage of patients positive for PIVKA-II (greater than or equal to 0.1 micrograms/ml) and those positive for AFP (greater than or equal to 20 ng/ml) were similar (77% and 74%, respectively). Pearson's correlation of coefficient between the PIVKA-II value and the AFP value in the 70 patients was 0.463. However, false-positive rates in patients with hepatic disease other than hepatocellular carcinoma were lower for PIVKA-II. Combined assessment of PIVKA-II and AFP increased positive rates and allowed exclusion of false-positive patients. The plasma PIVKA-II level is suggested to be useful as an indicator of warfarin control in patients with thrombotic disease, as a marker of hepatocellular carcinoma, and is particularly of value when assessed in combination with AFP.
journal_name
Cancerjournal_title
Cancerauthors
Deyashiki Y,Nishioka Y,Takahashi K,Kosaka Y,Suzuki Kdoi
10.1002/1097-0142(19891215)64:12<2546::aid-cncr282subject
Has Abstractpub_date
1989-12-15 00:00:00pages
2546-51issue
12eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Fas-expressing cytotoxic T lymphocytes (CTLs) are important antitumor immune effector cells in patients with hepatocellular carcinoma (HCC). The role of transforming growth factor beta 1 (TGF-beta1) in modulating the expression of Fas by CTLs is not known in HCC. The objectives of this study were to characte...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2136::aid-cncr1555
更新日期:2001-10-15 00:00:00
abstract::In a retrospective review (1950-1975) of the Mayo Clinic experience with seminomas (483 cases), twelve patients (2.5%) were found to have a retroperitoneal seminoma without evidence of testicular involvement. The mean age was 47 years (range, 31-67). Eleven patients were treated by radiation alone, with doses ranging ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820501)49:9<1934::aid-cncr2820
更新日期:1982-05-01 00:00:00
abstract::Forty-three patients with widely metastatic melanoma were studied. Visceral metastases were present in 79% of the patient group, including five patients with brain metastases. No patients were excluded because of "early death," etc., from analysis. All 43 patients received 24-hour DTIC infusions. Dosages for individua...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860601)57:11<2103::aid-cncr282
更新日期:1986-06-01 00:00:00
abstract::Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:2+<2795::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract::In 186 women with breast cancer, there was a progressive increase in the proportion of axillary nodal involvement as the number of pregnancies increased from zero to two or more (P = 0.026). Logistic regression analysis demonstrated that this effect was independent of the known relationship of age and tumor size to no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<981::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract:BACKGROUND:Complete maturation (cytodifferentiation) of treated metastatic Wilms' tumor is an infrequent occurrence. In a large series of reports, Wilms' metastases have generally contained malignant blastemic elements admixed with lesser amounts of cytodifferentiated mesenchyme. The authors describe a patient in whom ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19970415)79:8<1629::aid-cn
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Re...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.20756
更新日期:2005-01-15 00:00:00
abstract::Oxygen remains one of the most potent sensitizers of mammalian cells yet studied and, most important, it is maximumly sensitizing at physiologic concentrations. There is very good evidence that solid tumors of both experimental animals and man contain hypoxic and viable cells. In experimental animals hyperbaric oxygen...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(196810)22:4<809::aid-cncr2820220
更新日期:1968-10-01 00:00:00
abstract:BACKGROUND:As an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30720
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL). METHODS:A review of patient records ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23984
更新日期:2008-12-25 00:00:00
abstract::Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with methotrexate alone. Response rate was in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1502::aid-cncr2820
更新日期:1985-10-01 00:00:00
abstract::Quality assurance for the management of multicenter clinical trials requires timely patient and data accrual and consistency with design parameters. Data from central pathology review, treatment modality, and follow-up as well as trial end points direct the selection of appropriate compliance measures. To integrate th...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19941101)74:9+<2647::aid-cncr282
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Although the anticancer effects of progesterone therapy for patients with endometrial carcinoma are widely acknowledged, a detailed assessment of the resultant morphologic alterations in tumor tissue kinetics has hitherto been lacking. METHODS:Biopsy and hysterectomy specimens of 14 endometrial carcinomas (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980701)83:1<111::aid-cnc
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:The Danish Breast Cancer Cooperative Group (DBCG) 77B trial examined the relative efficacy of levamisole, single-agent oral cyclophosphamide, and the classic combination of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) against no adjuvant systemic therapy in high-risk breast cancer patients. The a...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.24969
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Although delay to diagnosis after a breast screening abnormality causes anxiety, its effect on prognosis is unknown. METHODS:Using pooled data from five Canadian organized breast cancer screening programs, the authors used unconditional logistic regression to evaluate the effect of delay to diagnosis on pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10453
更新日期:2002-04-15 00:00:00
abstract:BACKGROUND:The authors evaluated the role of 5-aminolevulinic acid (5-ALA)-induced fluorescence endoscopy (AFE) in the detection of flat urothelial lesions in light of the suggestions made for flat neoplastic lesions within the 1999 World Health Organization (WHO) classification of urinary bladder tumors. METHODS:From...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10821
更新日期:2002-09-15 00:00:00
abstract::An adequate operation for colorectal carcinoma involves removal of the primary tumor and wide excision of the mesentery with its contained regional lymph nodes and lymphovascular pathways. Enker and DeCosse state that radical resection, i.e., total mesenteric lymphadenectomy encompassing the origins of the complete ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2525::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11937
更新日期:2004-02-01 00:00:00
abstract::Over an 18-year period a distinctive large cell lymphoreticular neoplasm (Richter's transformation) developed in 9 patients with chronic lymphocytic leukemia. Clinical findings at the onset of Richter's transformation were remarkably uniform and consisted of the abrupt onset of fever, marked asymmetric lymphadenopathy...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800701)46:1<118::aid-cncr28204
更新日期:1980-07-01 00:00:00
abstract::A unique case of pulmonary rhabdomyosarcoma with an isolated, symptomatic small bowel metastasis is presented. The tumor affected the middle lobe, and was treated with a right pneumonectomy. Eleven months after the operation, an isolated small bowel metastasis, which produced intestinal obstruction, was resected. The ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840501)53:9<1948::aid-cncr2820
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Insular thyroid cancer (ITC) is an uncommon, poorly differentiated thyroid malignancy. To date, there have been no population-level studies of the characteristics and outcomes of patients with ITC. METHODS:The authors used the Surveillance, Epidemiology, and End Results (SEER) database from 1999 to 2007 to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26638
更新日期:2012-07-01 00:00:00
abstract::Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<131::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20782
更新日期:2005-01-01 00:00:00
abstract::A case-referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty-five male STS patients were thereby compared with 220 living and 110 dead population-based refe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<652::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract::Seventeen patients with carcinoma confined to the pancreas and the peripancreatic area received preoperative radiation therapy in an attempt to increase the resectability rate and to reduce the incidence of recurrence. The tumors were considered either unresectable or of borderline resectability. The radiation dose ra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801101)46:9<1945::aid-cncr2820
更新日期:1980-11-01 00:00:00
abstract::To evaluate the role of chemotherapy in local control of primary breast cancer, the incidence of local failure was evaluated in 768 patients treated with surgery and adjuvant, combination chemotherapy that contained fluorouracil, doxorubicin, and cyclophosphamide (FAC) at our institute between 1974 and 1982. Of these ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<394::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract::Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890101)63:1<51::aid-cncr282063
更新日期:1989-01-01 00:00:00
abstract::Three cases of peritoneal papillary serous carcinoma with a complete response to chemotherapy and long-term disease free survival are reported. All three patients presented with multifocal or diffuse peritoneal involvement. Microscopic ovarian serosal surface involvement was demonstrated in two cases. The ovaries were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860915)58:6<1371::aid-cncr2820
更新日期:1986-09-15 00:00:00
abstract:BACKGROUND:Despite the widespread use of Papanicolaou (Pap) smear screening, substantial morbidity and mortality from cervical carcinoma continue in the U.S. Although access to screening is a major barrier to use of the Pap smear, invasive cervical carcinoma (ICC) still is observed in health plan members who have compr...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:We investigated p16(INK4A) expression in branchial cleft cysts and its utility in distinguishing branchial cleft cysts from metastatic head and neck squamous cell carcinomas (SCCs) in fine-needle aspiration biopsies (FNABs). METHODS:A study set comprising 41 resections (15 SCC and 26 branchial cleft cysts) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20001
更新日期:2009-04-25 00:00:00