Is chemotherapy effective in reducing the local failure rate in patients with operable breast cancer?

abstract：:The authors report the case of a patient with malignant thymoma unresponsive to combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP] and cisplatin/VP-16) who subsequently achieved clinical response to continuous daily prednisone. A review of the literature indicates that predniso...

journal_title：Cancer

authors： Hu E,Levine J

更新日期：1986-03-15 00:00:00

abstract：BACKGROUND:The optimal weekly oral dose of sirolimus and intravenous nanoparticle albumin-bound paclitaxel (nab-paclitaxel) were evaluated. METHODS:A phase 1b study was performed to evaluate escalating doses of oral sirolimus (5-60 mg) on days 2, 9, and 16 with intravenous nab-paclitaxel (100 mg/m(2) ) on days 1, 8, a...

journal_title：Cancer

authors： Abu-Khalaf MM,Baumgart MA,Gettinger SN,Doddamane I,Tuck DP,Hou S,Chen N,Sullivan C,Lezon-Geyda K,Zelterman D,Hatzis C,Deshpande H,Digiovanna MP,Azodi M,Schwartz PE,Harris LN

更新日期：2015-06-01 00:00:00

abstract：:A unique case of pulmonary rhabdomyosarcoma with an isolated, symptomatic small bowel metastasis is presented. The tumor affected the middle lobe, and was treated with a right pneumonectomy. Eleven months after the operation, an isolated small bowel metastasis, which produced intestinal obstruction, was resected. The ...

journal_title：Cancer

authors： Avagnina A,Elsner B,De Marco L,Bracco AN,Nazar J,Pavlovsky H

更新日期：1984-05-01 00:00:00

abstract：:This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...

journal_title：Cancer

authors： Wahl RL

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...

journal_title：Cancer

authors： Jim MA,Pinheiro PS,Carreira H,Espey DK,Wiggins CL,Weir HK

更新日期：2017-12-15 00:00:00

abstract：:Acral erythema after high-dose cytosine arabinoside (Ara-C) has been described as a painful, sharply demarcated, and intense erythema of the palms and soles. This phenomenon occurred and is described in three out of three allogeneic bone marrow transplant (BMT) recipients who received high-dose Ara-C and total-body ir...

journal_title：Cancer

authors： Kampmann KK,Graves T,Rogers SD

更新日期：1989-06-15 00:00:00

abstract：BACKGROUND:The use of docetaxel prolongs survival for patients with castrate-resistant prostate cancer (CRPC). Inhibition of vascular endothelial growth factor (VEGF) with bevacizumab may further enhance the antitumor effect of docetaxel and estramustine in patients with CRPC. METHODS:This cooperative group trial enro...

journal_title：Cancer

authors： Picus J,Halabi S,Kelly WK,Vogelzang NJ,Whang YE,Kaplan EB,Stadler WM,Small EJ,Cancer and Leukemia Group B.

更新日期：2011-02-01 00:00:00

abstract：:A series of 108 prospectively collected human pancreata were evaluated histologically for the presence of acinar cell and ductal lesions. Foci of dysplastic acinar cells were present in 44% of the series. Some of the focal acinar cell abnormalities were similar to atypical acinar cell nodules which have been described...

journal_title：Cancer

authors： Longnecker DS,Shinozuka H,Dekker A

更新日期：1980-02-01 00:00:00

abstract：:From February 1972 to July 1975, 200 lung cancer patients were seen at the University of Rochester Cancer Center's Division of Radiation Oncology; 40% had squamous cell tumors and 87.5% had advanced disease localized to the thorax. Of the 160 patients who completed treatment, 101 were treated with continuous therapy s...

journal_title：Cancer

authors： Salazar OM,Rubin P,Brown JC,Feldstein ML,Keller BE

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...

journal_title：Cancer

authors： Perez EA,Barrios C,Eiermann W,Toi M,Im YH,Conte P,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Petersen JA,De Haas S,Hoersch S,Patre M,Ellis PA

更新日期：2019-11-15 00:00:00

abstract：:While investigating the cause of mild polycythemia in a young man, a testicular seminoma was discovered with unusual and tumor-dependent features: an absolute polycythemia with high plasma erythropoietin (EPO) levels, an overproduction of estradiol and testosterone, and a dramatic Leydig cell hyperplasia surrounding t...

journal_title：Cancer

authors： Reman O,Reznik Y,Casadevall N,Lacombe C,Troussard X,Mandard JC,Leporrier M,Mahoudeau J

更新日期：1991-11-15 00:00:00

abstract：:Computed tomography (CT) has emerged from the 1980s to play a dominant role in the pretreatment staging of renal and adrenal carcinomas. For detection, definition (staging), and determination of resectability or recurrence, CT with intravenous contrast enhancement, and more recently, magnetic resonance imaging (MRI) w...

journal_title：Cancer

authors： McClennan BL

更新日期：1991-02-15 00:00:00

abstract：:As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...

journal_title：Cancer

authors： Mushlin AI,Fintor L

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Several histologic classifications of thymomas have been proposed, and attempts have been made to correlate the different histologic subtypes to clinical behavior and prognosis. Recently, Marino and Müller-Hermelink and Kirchner et al. proposed a new morphologic classification of thymomas based on the resemb...

journal_title：Cancer

authors： Quintanilla-Martinez L,Wilkins EW Jr,Choi N,Efird J,Hug E,Harris NL

更新日期：1994-07-15 00:00:00

abstract：:Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

journal_title：Cancer

authors： Loewenstein MS,Zamcheck N

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:For patients with stage III through IVB head and neck squamous cell carcinoma (HNSCC), concurrent high-dose cisplatin plus radiation therapy is a widely accepted standard of care. HNSCC tumors that express high levels of vascular endothelial growth factor have been associated with a worse prognosis, and beva...

journal_title：Cancer

authors： Fury MG,Lee NY,Sherman E,Lisa D,Kelly K,Lipson B,Carlson D,Stambuk H,Haque S,Shen R,Kraus D,Shah J,Pfister DG

更新日期：2012-10-15 00:00:00

abstract：:This prospective evaluation of 5-fluorouracil (5-FU) and methyl-CCNU administered in combination to patients with surgery for histologically proved gastric adenocarcinoma is based upon 312 patients randomized between August 1974 and May 1980. Patients were stratified into three categories of resectability, (1) complet...

journal_title：Cancer

authors： Higgins GA,Amadeo JH,Smith DE,Humphrey EW,Keehn RJ

更新日期：1983-09-15 00:00:00

abstract：BACKGROUND:To assess the ability of [(18)F]fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) to predict the viability of residual masses after chemotherapy in patients with metastatic nonseminomatous germ cell tumors (GCT), PET results were compared in a blinded analysis with computed tomography (CT) sca...

journal_title：Cancer

authors： Kollmannsberger C,Oechsle K,Dohmen BM,Pfannenberg A,Bares R,Claussen CD,Kanz L,Bokemeyer C

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:A large amount of interindividual variability exists in the occurrence of symptoms in patients receiving chemotherapy (CTX). The purposes of the current study, which was performed in a sample of 582 oncology outpatients who were receiving CTX, were to identify subgroups of patients based on their distinct ex...

journal_title：Cancer

authors： Miaskowski C,Cooper BA,Melisko M,Chen LM,Mastick J,West C,Paul SM,Dunn LB,Schmidt BL,Hammer M,Cartwright F,Wright F,Langford DJ,Lee K,Aouizerat BE

更新日期：2014-08-01 00:00:00

abstract：:The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as "slight" and "marked." The 39% frequency in the marked infiltration group at the mucosal stage di...

journal_title：Cancer

authors： Tsujitani S,Kakeji Y,Watanabe A,Kohnoe S,Maehara Y,Sugimachi K

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:An intensive in-patient Phase II study of continuous infusion recombinant human interleukin-2 (rhIL-2) 3 X 10(6) Roche units (9 MIU/m2)/day plus intramuscular injection of interferon-alpha-2a (rIFN-alpha-2a) 5 x 10(6) U/m2/day, four consecutive days per week, was performed to determine whether four consecuti...

journal_title：Cancer

authors： Eton O,Talpaz M,Lee KH,Rothberg JM,Brell JM,Benjamin RS

更新日期：1996-03-01 00:00:00

abstract：:The objective of this study was to evaluate the sensitivity of two methods for determining bone marrow involvement with non-Hodgkin's lymphoma. These methods were histologic review of bone marrow aspirates, and clot sections versus in vitro growth of lymphoma colonies on soft agar. Forty-two bone marrow aspirates were...

journal_title：Cancer

authors： Smith SD,Kisker S,Bush L,Trueworthy RC

更新日期：1984-04-15 00:00:00

abstract：:Carcinoma of the large bowel is rare in persons under the age of 30, and generally presents with advanced stages of disease. From 1964 to 1984, 30 patients presented with nonfamilial large bowel malignancies. Seventeen patients were male, and 13 female (age range, 8-25 years). In 15 patients the primary was in the rig...

journal_title：Cancer

authors： Rao BN,Pratt CB,Fleming ID,Dilawari RA,Green AA,Austin BA

更新日期：1985-03-15 00:00:00

abstract：BACKGROUND:Although it induces a relevant reduction in the risk of both visceral metastases and locoregional recurrences, the combination of chemotherapy and surgery only marginally improves the survival of patients with Stage IIIA(N2) (International Union Against Cancer staging and classification system) nonsmall-cell...

journal_title：Cancer

authors： Andre F,Grunenwald D,Pujol JL,Girard P,Dujon A,Brouchet L,Brichon PY,Westeel V,Le Chevalier T

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...

journal_title：Cancer

authors： Nakamura S,Yao T,Aoyagi K,Iida M,Fujishima M,Tsuneyoshi M

更新日期：1997-01-01 00:00:00

abstract：:Forty-six cases of resected lung cancer, including 20 cases at Stages I and II and 26 cases at Stage III (N2), were subdivided into two groups: a good prognosis group with a longer survival period and a poor prognosis group in which the patients died earlier of the cancer. From paraffin-embedded lymph node tissues of ...

journal_title：Cancer

authors： Ogawa J,Iwazaki M,Tsurumi T,Inoue H,Shohtsu A

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...

journal_title：Cancer

authors： Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Androgen receptor blocking agents have become an established form of therapy for men with disseminated prostate carcinoma. The purpose of this study was to evaluate markers of bone turnover and to measure bone mineral densities (BMD) in men with disseminated prostate carcinoma treated with combined androgen ...

journal_title：Cancer

authors： Diamond T,Campbell J,Bryant C,Lynch W

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate whether estramustine (estrogen mustard [EM]) is a promising alternative in the treatment of patients with epithelial ovarian carcinoma (OVCA). EM is a microtubule-associated protein (MAP) specific antimicrotubule agent with low toxicity. METHODS:The authors investigated ...

journal_title：Cancer

authors： Chen Z,Fadiel A,Jia JF,Sakamoto H,Carbone R,Naftolin F

更新日期：1999-06-15 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the time to treatment failure and survival rate of the three-drug combination of doxorubicin, cisplatin, and ifosfamide as primary and postoperative, adjunctive treatment for teenagers and adults with osteosarcoma (OS). METHODS:Sixty-three eligible patients with n...

journal_title：Cancer

authors： Zalupski MM,Rankin C,Ryan JR,Lucas DR,Muler J,Lanier KS,Budd GT,Biermann JS,Meyers FJ,Antman K

更新日期：2004-02-15 00:00:00