Efficacy of prolonged intermittent therapy with combined 5-FU and methyl-CCNU following resection for gastric carcinoma. A Veterans Administration Surgical Oncology, Group report.

Abstract:

:This prospective evaluation of 5-fluorouracil (5-FU) and methyl-CCNU administered in combination to patients with surgery for histologically proved gastric adenocarcinoma is based upon 312 patients randomized between August 1974 and May 1980. Patients were stratified into three categories of resectability, (1) complete, (2) proven incomplete, and (3) nonresectable, prior to random treatment assignment to surgery alone or surgery followed by adjuvant chemotherapy. Drug therapy consisted of discrete 5-day courses administered at 7-week intervals. Toxic reactions were reported in association with 42% of the courses. Treatment was suspended or discontinued in 6% of the courses because of hematologic toxicity. Treated patients with curative resections experienced a more favorable survival than did controls, but the early advantage was lost by the end of the second follow-up year. However, no statistically significant improvements in survival or reductions in risks of recurrence were observed. Similar proportions of treated and control deaths were attributable to residual or recurrent disease.

journal_name

Cancer

journal_title

Cancer

authors

Higgins GA,Amadeo JH,Smith DE,Humphrey EW,Keehn RJ

doi

10.1002/1097-0142(19830915)52:6<1105::aid-cncr2820

subject

Has Abstract

pub_date

1983-09-15 00:00:00

pages

1105-12

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

52

pub_type

临床试验,杂志文章,随机对照试验

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