Abstract:
:This prospective evaluation of 5-fluorouracil (5-FU) and methyl-CCNU administered in combination to patients with surgery for histologically proved gastric adenocarcinoma is based upon 312 patients randomized between August 1974 and May 1980. Patients were stratified into three categories of resectability, (1) complete, (2) proven incomplete, and (3) nonresectable, prior to random treatment assignment to surgery alone or surgery followed by adjuvant chemotherapy. Drug therapy consisted of discrete 5-day courses administered at 7-week intervals. Toxic reactions were reported in association with 42% of the courses. Treatment was suspended or discontinued in 6% of the courses because of hematologic toxicity. Treated patients with curative resections experienced a more favorable survival than did controls, but the early advantage was lost by the end of the second follow-up year. However, no statistically significant improvements in survival or reductions in risks of recurrence were observed. Similar proportions of treated and control deaths were attributable to residual or recurrent disease.
journal_name
Cancerjournal_title
Cancerauthors
Higgins GA,Amadeo JH,Smith DE,Humphrey EW,Keehn RJdoi
10.1002/1097-0142(19830915)52:6<1105::aid-cncr2820subject
Has Abstractpub_date
1983-09-15 00:00:00pages
1105-12issue
6eissn
0008-543Xissn
1097-0142journal_volume
52pub_type
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