Abstract:
BACKGROUND:Conditional survival is clinically useful, particularly for patients with malignant disease who have a poor prognosis. However, there are no published data on the conditional median survival of patients with advanced carcinoma on a population basis. METHODS:Data on 217,573 patients with breast, colorectal, lung, or prostate carcinoma who were newly diagnosed with distant disease between 1973 and 1995 and who were followed through the end of 1997 were extracted from the Surveillance, Epidemiology, and End Results (SEER) data base of the National Cancer Institute. The Kaplan-Meier method was employed to estimate conditional median survival and 95% confidence intervals at 0-5 years after the initial diagnosis. RESULTS:The conditional median survival increased as time elapsed after the initial diagnosis. The increase was slowest and almost leveled off among patients with prostate carcinoma. The median survival of patients with breast carcinoma increased relatively linearly with time, i.e., 5-6 months per year. Conversely, there was a rapid increase in the conditional median survival according to the amount of time since diagnosis for patients with lung and colorectal carcinoma. The trend was most pronounced for patients with colorectal carcinoma. At 5 years after the initial diagnosis, the remaining median survival was longest for patients with colorectal carcinoma, almost 6 years (71.5 months), followed by patients with lung carcinoma (52.5 months), breast carcinoma (42.5 months), and prostate carcinoma (34.5 months). Although race was a correlate with initial survival, gender and age had more impact on late conditional survival. CONCLUSIONS:The conditional median survival provides useful and encouraging information for patients who survive with advanced disease and for healthcare professionals who treat these patients. However, the information should be used carefully, taking the limitations of these data into account.
journal_name
Cancerjournal_title
Cancerauthors
Kato I,Severson RK,Schwartz AGdoi
10.1002/1097-0142(20011015)92:8<2211::aid-cncr1565subject
Has Abstractpub_date
2001-10-15 00:00:00pages
2211-9issue
8eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20011015)92:8<2211::AID-CNCR1565journal_volume
92pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS:Sixty-two patients with Stage IB-IV gastric/gastroesophageal a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20591
更新日期:2004-11-01 00:00:00
abstract::Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850915)56:6<1356::aid-cncr2820
更新日期:1985-09-15 00:00:00
abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19931015)72:8<2517::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract::The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860715)58:2<264::aid-cncr28205
更新日期:1986-07-15 00:00:00
abstract:BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<3947::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:Squamous cell lung carcinoma (SLC), the most frequent type of lung cancer, generally is treated surgically and its prognosis is poor. The only current clinically useful prognostic criterion is lymph node staging (TNM classification). Expression of a novel tumor-associated carbohydrate epitope Gal beta 1-3[Fu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1867::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:New biologic prognostic factors are needed to guide the treatment of patients with colorectal cancer. The prognostic value of the altered expression of the cell surface glycoprotein gp78, which has been implicated in tumor-cell invasion and metastasis as an autocrine motility factor (AMF) receptor, was evalu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941001)74:7<1855::aid-cncr2820
更新日期:1994-10-01 00:00:00
abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<222::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract::Histologic examination of bone-marrow from the posterior iliac crest was routinely done as a pretreatment staging procedure in 203 consecutive patients with small-cell anaplastic carcinoma of the lung. Subtyping of the patients according to the WHO classification included 27.8% with "fusiform" cell type (WHO II,1), 28...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197706)39:6<2563::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract::Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31769
更新日期:2018-12-15 00:00:00
abstract::A retrospective study was made of the surgical treatment of distant metastases from melanoma in 143 patients. The determinants of survival benefit were: (1) successful complete resection of all clinical disease; (2) single versus multiple metastatic site; and (3) anatomic location of disease. Complete resection was ac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850901)56:5<1222::aid-cncr2820
更新日期:1985-09-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) determinations performed in the milk of a nursing mother with an inoperable breast cancer revealed a 10-15-fold higher level compared with CEA levels in the milk of healthy nursing women. CEA was highly elevated in the milk of the tumor-bearing breast (1100 +/- 100 ng/ml) and moderately ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801101)46:9<2091::aid-cncr2820
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL). METHODS:Failure-free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Easter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30979
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) is an autosomal dominant disease characterized by early-onset intestinal neoplasms, localization of tumors in the proximal colon, and frequent association with cancers at other sites, especially the endometrium, skin, and stomach. The identi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3493::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Little is known about the size and characteristics of the decision-support networks of women newly diagnosed with breast cancer and whether their involvement improves breast cancer treatment decisions. METHODS:A population-based sample of patients newly diagnosed with breast cancer in 2014 and 2015, as repo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30848
更新日期:2017-10-15 00:00:00
abstract::The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911215)68:12<2612::aid-cncr282
更新日期:1991-12-15 00:00:00
abstract:BACKGROUND:A clinicopathologic evaluation of clinical Stage I and II uterine sarcoma was done by the Gynecologic Oncology Group from 1979-1988. METHODS:After all eligibility criteria were met, 453 cases were evaluable and analyzed for prognostic factors. RESULTS:Of the 301 mixed mesodermal tumors (MMT), 167 were homo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710440
更新日期:1993-02-15 00:00:00
abstract::To assess the efficacy of performing both computed tomography (CT) of the thorax and upper abdomen and whole-body gallium scintigraphy for staging lung cancer, the results of each test were compared with those obtained by chest radiography and clinical examination in 100 patients. Clinical efficacy was defined in term...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891001)64:7<1404::aid-cncr2820
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Radiotherapy (RT) has been a risk factor for development of soft tissue sarcomas (STS). The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24462
更新日期:2009-09-15 00:00:00
abstract:BACKGROUND:Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. METHODS:The cancer cell dissociation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950315)75:6+<1554::aid-cncr282
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:The treatment of advanced, inoperable, or recurrent parotid tumors represents a clinical challenge. The results obtained with conventional radiotherapy are disappointing. To improve the early response and local control of parotid tumors, local microwave hyperthermia was used in combination with ionizing radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19950215)75:4<908::aid-cncr28207
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Approximately 30-50% of patients with myelofibrosis with myeloid metaplasia (MMM) demonstrate detectable cytogenetic abnormalities, the prognostic value of which has not been completely defined by previous retrospective studies. The current prospective study addresses this issue in the context of currently a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21358
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti-neuroectodermal antibodies in the absence of PND. Whether...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21088
更新日期:2005-06-15 00:00:00
abstract::The unequal burden of cancer in minority and underserved communities nationally and in Maryland is a compelling crisis. The Maryland Special Populations Cancer Research Network (MSPN) developed an infrastructure covering Maryland's 23 jurisdictions and Baltimore City through formal partnerships between the University ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22158
更新日期:2006-10-15 00:00:00
abstract::Three children with nonlymphoblastic, non-Hodgkin's lymphomas, showed morphologic features that suggested nonlymphoblastic T-cell origin. Tissue for immunologic study was available from two of the three patients; both showed immunophenotypes of T-cells. Although nearly all T-cell lymphomas in children are lymphoblasti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870615)59:12<2099::aid-cncr282
更新日期:1987-06-15 00:00:00
abstract::One-hundred-eighty-eight children up to 16 years of age were randomized in the second National Wilms' Tumor Study (NWTS) with tumors that were confined to the kidney and that had been totally excised (Group I). Most fared well whether treated for six or for 15 months with both actinomycin D (AMD) and vincristine (VCR)...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810501)47:9<2302::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract:BACKGROUND:Sialyl-Tn (STn) represents an aberrantly glycosylated mucin epitope that is expressed in breast carcinoma and other adenocarcinomas and is an important factor in the development of novel immunotherapeutic approaches. The primary aim of the current study was to investigate the influence of STn expression on t...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19971215)80:12<2240::aid-c
更新日期:1997-12-15 00:00:00
abstract:BACKGROUND:Shared decision-making (SDM) occurs when a patient partners with their oncologist to integrate personal preferences and values into treatment decisions. A key component of SDM is the elicitation of patient preferences and values, yet little is known about how and when these are elicited, communicated, priori...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32961
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Preoperative chemoradiation improves survival in esophageal and gastroesophageal junction (GEJ) cancer. We evaluated irinotecan and cisplatin as induction chemotherapy followed by concurrent chemoradiation in esophageal cancer. METHODS:Patients with uT1N1M0 or uT2-4NanyM0 resectable squamous cancer or adeno...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26591
更新日期:2012-06-01 00:00:00