Abstract:
:A retrospective study was made of the surgical treatment of distant metastases from melanoma in 143 patients. The determinants of survival benefit were: (1) successful complete resection of all clinical disease; (2) single versus multiple metastatic site; and (3) anatomic location of disease. Complete resection was achieved with single- and multiple-site lesions in 67% and 31% of the patients, respectively, yielding corresponding 5-year survival rates of 33% and 9%, respectively. Incomplete resection yielded little survival benefit. Soft tissue and extraregional nodal lesions were completely resectable in 70%, whereas pulmonary, extrahepatic abdominal visceral, and osseous lesions were in 40% of the patients, resulting in similar 5-year survival rates of 17% to 22%. The operative mortality rate was 1.4% (2/143). Unsuccessful resection frequently led to very long hospitalization periods for complications and disease, with some patients spending more than 50% of their remaining survival time in the hospital. These observations suggest that, with proper selection of patients, guided by these determinants, surgical resection can offer a reasonable expectation of prolonged survival.
journal_name
Cancerjournal_title
Cancerauthors
Overett TK,Shiu MHdoi
10.1002/1097-0142(19850901)56:5<1222::aid-cncr2820subject
Has Abstractpub_date
1985-09-01 00:00:00pages
1222-30issue
5eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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