Abstract:
BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospectively reviewed 6624 patients with localized prostate cancer who underwent radical prostatectomy from 2000 to 2010 at Memorial Sloan-Kettering Cancer Center. Patients were stratified by surgical approach (open, laparoscopic, or robotic) and by risk category (low, intermediate, or high). Patients with low-risk disease, without intervention, and with a minimum follow-up of 6 months were considered to have elected AS. RESULTS:The number of patients who had AS increased from <20 per year between 2000 and 2004 to ≥ 100 per year between 2007 and 2009. Over the same decade, the number of patients who underwent MIS (laparoscopic or robotic) increased from zero to 63% of all surgical cases. The percentage of patients in the intermediate-risk and high-risk categories increased over time, whereas the percentage of patients in the low-risk category decreased (odds ratio [OR] per year, 0.91; 95% confidence interval [CI], 0.89-0.92; P < .0005). The proportion of patients who underwent surgery with Gleason 6 tumors decreased over time (OR per year, 0.87; 95% CI, 0.85-0.88; P < .0005), whereas pathologic stage and Gleason score increased (P < .0005). The proportion of low-risk patients decreased across all types of surgery, and the largest decrease was observed for robotic surgery (P < .0005). CONCLUSIONS:A reverse stage shift was observed in patients who underwent radical prostatectomy after 2000 despite the introduction and rapid proliferation of MIS. This shift may have been caused in part by the increased use of AS and an institutional focus on the treatment of higher risk disease.
journal_name
Cancerjournal_title
Cancerauthors
Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VPdoi
10.1002/cncr.26132subject
Has Abstractpub_date
2011-11-01 00:00:00pages
4855-60issue
21eissn
0008-543Xissn
1097-0142journal_volume
117pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Screening colonoscopy (SC) for colorectal cancer (CRC) is underused by Latino individuals. The current randomized clinical trial examined the impact of 3 interventions: 1) patient navigation; 2) patient navigation plus standard Centers for Disease Control and Prevention print materials; and 3) patient naviga...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.32541
更新日期:2020-02-15 00:00:00
abstract::The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810201)47:3<452::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract::Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197806)41:6<2420::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract::Pulmonary fibrosis is a well-recognized complication of bleomycin therapy. Detection of bleomycin-induced pulmonary fibrosis by computed axial tomographic scanning (CT) has not been reported. We report on a patient in whom the development of lesions on chest CT scan following cessation of chemotherapy (including bleom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810115)47:2<236::aid-cncr28204
更新日期:1981-01-15 00:00:00
abstract::Lymphoblasts from "null cell" acute lymphocytic leukemia (ALL) were analyzed for the pattern of proliferation displayed in a mixed lymphocyte reaction (MLR), the presence of a B cell surface antigen, and for the presence of intracytoplasmic immunoglobulin (ICIg). "Null cell" ALL was defined by cytologic and cytochemic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1622::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26098
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Amplification of erb-B2 and myc shows prognostic value in patients with operable breast cancer. Amplification is usually detected in tumor samples remaining after pathologic work-up, preventing the examination of small tumors. METHODS:Tumor imprints that contained low numbers of contaminating normal cells w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950601)75:11<2681::aid-cncr282
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC). Furthermore,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29547
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Timely delivery of care has been identified by the Institute of Medicine as an indicator for quality health care, and treatment delay is a potentially modifiable obstacle that can contribute to the disparities among African American (AA) and Caucasian patients in prostate cancer recurrence and mortality. Usi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27975
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence-free survival. In the current study, the authors attempted to analyze 21 patients genetically and cli...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11322
更新日期:2003-05-01 00:00:00
abstract::Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890315)63:6<1166::aid-cncr2820
更新日期:1989-03-15 00:00:00
abstract::The long-term cancer specific survival based on individual follow-up and analysis of prospectively collected data from 1061 patients undergoing resection for carcinoma of the rectum is presented. All patients were operated on and managed by one surgeon. Survival data for 978 cases were analyzed according to the method...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800601)45:11<2902::aid-cncr282
更新日期:1980-06-01 00:00:00
abstract::An autopsy case of prostaglandin E-producing hepatocellular carcinoma with hypercalcemia is presented in this article. A 72-year-old man showed high serum calcium levels (14.2 to 17.3 mg/100 ml) and hypophosphatemia. The plasma level of immunoreactive parathyroid hormone was below the normal range. Administration of o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1813::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Intensity-modulated radiation therapy (IMRT) is a novel approach to the planning and delivery of radiation therapy. The prevalence of IMRT use among radiation oncologists in the U.S. appears to be increasing, despite limited data evaluating its risks and benefits. METHODS:A random sample of radiation oncolo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21284
更新日期:2005-09-15 00:00:00
abstract:BACKGROUND:Breast reconstruction is performed with increasing frequency and has become important in the treatment of mastectomy patients. METHODS:The development of recurrent carcinoma after a mastectomy and transverse rectus abdominus myocutaneous (TRAM) flap procedure is described. RESULTS:The lesion was nonpalpabl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941115)74:10<2804::aid-cncr282
更新日期:1994-11-15 00:00:00
abstract::In recent years, an increased understanding of T-cell-regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies-even those that historically were not believed to be sensitive to immune therapy. With this, t...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29889
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Ewing sarcoma family of tumors (ESFTs) are the second most common bone tumor, that most often affects persons ages 3-40 years. The ESFTs rely on signaling through the insulin-like growth factor-1 receptor (IGF-1R) for growth and transformation. The current studies were performed to determine the levels of IG...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011201)92:11<2941::aid-cncr100
更新日期:2001-12-01 00:00:00
abstract::Three cases of carcinoid tumor arising in the trachea are reported and contrasted with carcinoids arising in bronchi and carcinoids in general. Only eleven other documented examples of tracheal carcinoids are found in the English literature. The true prevalence of carcinoids primary in the trachea cannot be accurately...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197812)42:6<2870::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract::Tumor-bearing patients with breast cancer were assayed for their natural killer (NK) cell activity and for the function of activated cytotoxic T-cells, as assessed by lectin-dependent cellular cytotoxicity (LDCC). Tumor-bearing patients with breast cancer had a significant increase in NK activity and in LDCC, as compa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890515)63:10<1985::aid-cncr282
更新日期:1989-05-15 00:00:00
abstract::In a 10-year incidence survey of breast cancer in the City of Boston, 14 cases in American Chinese women were observed, while approximately 13 were expected on the basis of age-specific incidence in the white population. In Hawaii, on the other hand, while breast cancer incidence rates for ethnic Chinese are approxima...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840101)53:1<187::aid-cncr28205
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32148
更新日期:2019-08-15 00:00:00
abstract::In order to determine whether high-dose combination chemotherapy was active in chemotherapy resistant patients, 19 patients, (9 with small cell bronchogenic carcinoma, 6 with embryonal cell carcinoma, 2 with diffuse histiocytic lymphoma, 1 with Hodgkin's disease and 1 with chondrosarcoma), 18 of whom had had extensive...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800615)45:12<3075::aid-cncr282
更新日期:1980-06-15 00:00:00
abstract::The records of 51 patients with esophageal carcinoma were reviewed. Twenty-two patients underwent attempted curative resection with a mean survival of 7.7 months. Twenty patients underwent primary radiotherapy (mean survival, 4.3 months). Nine patients received palliative therapy alone (mean survival, 2.8 months). Sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840901)54:5<918::aid-cncr28205
更新日期:1984-09-01 00:00:00
abstract::Cutaneous squamous cell carcinomas (SCC) arising in actinically damaged skin, unassociated with chronic inflammation or injury, are generally regarded as nonaggressive lesions. These tumors occasionally recur or metastasize, however, as do de novo SCC. The authors reviewed 63 patients with cutaneous SCC of the trunk o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850901)56:5<1099::aid-cncr2820
更新日期:1985-09-01 00:00:00
abstract::Standardized incidence ratio for cancer in Norwegian Seventh-Day Adventists compared with the general population was not significantly different from unity (men 91, women 97). Persons converting late in life had a higher incidence than those converting at an earlier age. Respiratory cancers (standardized incidence rat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910801)68:3<666::aid-cncr28206
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polym...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25938
更新日期:2011-08-15 00:00:00
abstract::Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1180::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the efficacy and safety of irinotecan (CPT-11) as second-line therapy in patients with advanced cervical carcinoma. METHODS:Sixteen patients with platinum-resistant squamous cell carcinoma were treated with CPT-11 as second-line therapy. CPT-11 was administered in repea...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19980115)82:2<334::aid-cnc
更新日期:1998-01-15 00:00:00
abstract:BACKGROUND:Non-Hodgkin lymphoma (NHL), the most common cancer of the lymphatic system, is of unknown etiology. The identification of etiologic factors in the onset of NHL is a key event that could facilitate the prevention and cure of this malignancy. Simian virus 40 (SV40) has been considered an oncogenic agent in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29404
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Patterns of and progress against childhood cancer have been reported on multi-institution, regional, national, and international bases by several sources in the past. These sources have included clinical cooperative group trials and population-based registries. In general, the population-based surveys have e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12<2321::aid-c
更新日期:1997-12-15 00:00:00