Abstract:
BACKGROUND:Amplification of erb-B2 and myc shows prognostic value in patients with operable breast cancer. Amplification is usually detected in tumor samples remaining after pathologic work-up, preventing the examination of small tumors. METHODS:Tumor imprints that contained low numbers of contaminating normal cells were obtained from small tumors. The prognostic value of erb-B2 and myc amplification in imprint breast preparations was examined, using the polymerase chain reaction (PCR) to determine gene copy number. Tumor material was obtained from 162 patients with breast cancer operated 1975-1976. RESULTS:Amplification of erb-B2 existed in 21% and myc in 16% of the patients. Both erb-B2 and myc amplification showed prognostic significance in univariate analysis for survival and relapse free survival. In multivariate analysis, erb-B2 was a significant factor. In small tumors less than 13 mm in greatest dimension, erb-B2 showed prognostic significance for survival but not for relapse free survival. CONCLUSIONS:The use of imprints/PCR allows the detection of gene amplification in breast cancer. The procedure is suitable for the analysis of small tumors and can be used to examine very small tumors, such as those detected mammographically.
journal_name
Cancerjournal_title
Cancerauthors
Lönn U,Lönn S,Nilsson B,Stenkvist Bdoi
10.1002/1097-0142(19950601)75:11<2681::aid-cncr282subject
Has Abstractpub_date
1995-06-01 00:00:00pages
2681-7issue
11eissn
0008-543Xissn
1097-0142journal_volume
75pub_type
杂志文章相关文献
CANCER文献大全abstract::A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880815)62:4<686::aid-cncr28206
更新日期:1988-08-15 00:00:00
abstract:BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23391
更新日期:2008-05-15 00:00:00
abstract::Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1904::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns of fatigue and predictors of clinically significant fatigue 1 year after treatment completion. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32927
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:This study was designed to evaluate the significance of tumor angiogenesis and angiogenic factors such as hepatocyte growth factor (HGF) and c-Met in determining the prognoses of 93 patients with endometrial carcinoma. METHODS:By immunohistochemical staining, this retrospective study investigated tumor angi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980201)82:3<520::aid-cnc
更新日期:1998-02-01 00:00:00
abstract::The development of resistance to purine analogs defines a poor-risk subset of patients with chronic lymphocytic leukemia (CLL). Although in recent years chemoimmunotherapeutic combinations such as fludarabine, cyclophosphamide, and rituximab have induced response rates of 95% in previously untreated patients and incre...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24329
更新日期:2009-07-01 00:00:00
abstract::Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3<419::aid-cncr28206
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:This study explores whether externalizing religious and spiritual beliefs is associated with advanced-stage colon cancer at initial oncology presentation and whether this association is stronger for blacks than for whites. METHODS:Patients who had newly diagnosed, invasive colon cancer were recruited at 9 s...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31351
更新日期:2018-06-15 00:00:00
abstract::Elevated serum levels of carcinoembryonic antigen (CEA) were found in 70% of 141 patients with advanced gastrointestinal (GI) cancers. Serial CEA measurements were performed on 70 patients before and during chemotherapy. The majority were treated with 5-FU and Methyl-CCNU (33 patients), 5-FU (19 patients), or 5-FU and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197910)44:4<1222::aid-cncr282044
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Breast carcinoma survivors are the largest segment of the expanding cancer survivor community. As a result, there has been increasing discussion of the safety and efficacy of hormone replacement therapy for women with a past history of breast carcinoma. Little is known about the willingness of older breast c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21654
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c
更新日期:1997-12-01 00:00:00
abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<507::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Aggressive non-Hodgkin's lymphoma is now often curable with chemotherapy. The International Prognostic Index (IPI) was recently developed to predict patient survival on the basis of pretreatment clinical features. However, classical multivariate regression models such as the IPI fail to detect time-dependent...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-05-15 00:00:00
abstract::The existing system for solid tumor evaluation is criticized and revised criteria are proposed. The foundation for this analysis is a tumor stimulation experiment to determine the distribution associated with measurement of solid tumors. This tumor simulation experiment was conducted among 26 oncologists in order to a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800901)46:5<1286::aid-cncr2820
更新日期:1980-09-01 00:00:00
abstract::An unusual upper esophageal polypoid tumor was found to be predominantly a carcinoid tumor and in part a mucin-producing adenocarcinoma. A review of literature showed this to be a unique tumor in this location. ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197911)44:5<1853::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::Amputation is often a component in the treatment of bone tumors such as osteogenic sarcoma, which is most prevalent in the adolescent age group. Adaptation to cancer and loss of a limb requires a significant multidimensional effort. To examine the role of social support systems, 27 adolescents who had undergone amputa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<965::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:Obesity is a well known risk factor for the development of endometrial cancer; however, weight alone does not account for all cases. The authors hypothesized that insulin resistance also contributes to an increased risk for endometrial cancer. Adiponectin is a protein secreted by adipose cells and has been s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21866
更新日期:2006-06-01 00:00:00
abstract::The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3+<1139::aid-cncr282
更新日期:1994-08-01 00:00:00
abstract::A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2324::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Patients with bulky laryngopharyngeal masses and a relative or absolute contraindication to general anesthesia present diagnostic difficulties. In the current study, the authors assessed the utility of transcutaneous ultrasound-guided Tru-Cut biopsy (USGTCB) under local anesthesia in such individuals. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22679
更新日期:2007-06-01 00:00:00
abstract::The descriptive epidemiologic features of bladder cancer and lung cancer in Los Angeles County were studied for the period 1972-1976, using data from the Los Angeles County/University of Southern California Cancer Surveillance Program. The incidence pattern for bladder cancer was found to differ markedly from the patt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830215)51:4<675::aid-cncr28205
更新日期:1983-02-15 00:00:00
abstract::The authors have performed a clinical and statistical analysis of the presenting features of adult acute leukemia classified according to the French-American-British (FAB) hematopathologic criteria. Observations were made on 70 variables of history, physical examination, and laboratory examination recorded for 195 pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2460::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease. Furthermore, those studies were conducted when the currently accepted standards in diagnostics and therapy had not been fully established. The o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22919
更新日期:2007-09-15 00:00:00
abstract::Of a total of 1561 patients registered in the Intergroup Rhabdomyosarcoma Study (IRS) as of May 1983, 78 patients (5%) were younger than 1 year of age. These infants did not differ from the older children (1-20 years of age) in male/female ratio, clinical grouping, or survival rates. Infants younger than 1 year of age...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861215)58:12<2606::aid-cncr282
更新日期:1986-12-15 00:00:00
abstract:BACKGROUND:In the current study, the authors focused on determinants influencing the quality of care and variations in the actual quality of integrated care for patients with nonsmall cell lung cancer (NSCLC) to estimate whether there is room for improvement. METHODS:The authors tested the quality of integrated care f...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.22986
更新日期:2007-10-15 00:00:00
abstract::Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia. Thymic carcinomas may metastasize outside of the thorax and are associated with a very poor prognosis. Complete responses of thymic carcinoma to chemotherapy a...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:10.1002/1097-0142(19901115)66:10<2092::aid-cncr282
更新日期:1990-11-15 00:00:00
abstract:BACKGROUND:Brain metastases from soft tissue sarcoma (STS) are uncommon. To the authors' knowledge limited information is available regarding the influence of the initial STS site, the significance of parenchymal versus leptomeningeal metastases, and the role of surgical resection. METHODS:STS patients evaluated betwe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10554
更新日期:2002-05-15 00:00:00
abstract:BACKGROUND:The authors examined whether survivors from the Childhood Cancer Survivor Study were less likely to be in higher-skill occupations than a sibling comparison and whether certain survivors were at higher risk for lower-skill jobs. METHODS:The authors created 3 mutually exclusive occupational categories for pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25867
更新日期:2011-07-01 00:00:00
abstract::In order to search for the histogenesis and progression of colorectal cancer, the background mucosas of 18 patients with a single colorectal cancer, apart from familial adenomatosis coli, were studied by a step sectioning method. Three early minute cancers (3-5 mm in diameter) were detected in the apparently normal mu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880215)61:4<829::aid-cncr28206
更新日期:1988-02-15 00:00:00