Abstract:
:Elevated serum levels of carcinoembryonic antigen (CEA) were found in 70% of 141 patients with advanced gastrointestinal (GI) cancers. Serial CEA measurements were performed on 70 patients before and during chemotherapy. The majority were treated with 5-FU and Methyl-CCNU (33 patients), 5-FU (19 patients), or 5-FU and mitomycin-C (8 patients). In 49 patients with colorectal carcinoma who had elevated serum CEA prior to chemotherapy, 18 had objective partial tumor remission, 16/18 (89%) showed definite decrease in CEA level, one had no change, and one had an increase CEA titer. Thirty-one patients had either stable disease (10 patients) or increasing disease (21 patients) while on chemotherapy. Of these patients four showed decrease in CEA, eight had no change, and 19 had increase in CEA levels as compared to pretreatment value. The survival of patients with a decrease in CEA during chemotherapy was statistically significant (p = .03) as compared to survival of those with no change or increasing CEA levels. In 21 patients with other GI cancers, the correlation between the clinical response and change in CEA level observed was not as definite as in patients with colorectal carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
Al-Sarraf M,Baker L,Talley RW,Kithier K,Vaitkevicius VKdoi
10.1002/1097-0142(197910)44:4<1222::aid-cncr282044subject
Has Abstractpub_date
1979-10-01 00:00:00pages
1222-5issue
4eissn
0008-543Xissn
1097-0142journal_volume
44pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:AEs observed during 1 of 3 randomized chemotherapy regimens (vincristine, dactinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26358
更新日期:2012-02-15 00:00:00
abstract::This paper reports the prognosis results of a retrospective study of over 2000 cases of uterine cervix carcinoma totally treated at Institut Gustave-Roussy from 1950 to 1963. From the study of their long-term survival, an overall cure rate was estimated at 49% seven years after the start of primary treatment. A study ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<203::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract::Currently attention is focused on the testicle as a site of leukemic relapse. Leukemic involvement of the ovary has been described in several autopsy series with an incidence of 11-50% in patients with bone marrow relapse, but has rarely been reported during the clinical course of leukemia. In this report, four girls ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820801)50:3<587::aid-cncr28205
更新日期:1982-08-01 00:00:00
abstract::Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891201)64:11<2203::aid-cncr282
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Bloody nipple discharge is a significant clue in the detection of ductal carcinoma of the breast. In the past, pathologic diagnoses were obtained exclusively via excision, but recently developed mammoscopic techniques have been found to yield valuable information relating to the diagnosis of intraductal lesi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20657
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:Aprotinin has been used to decrease blood loss with complicated cardiac surgery but has not been investigated in extrapleural pneumonectomy, an operation that does not use cardiopulmonary bypass. In this prospective, randomized, placebo-controlled, double-blind trial, the authors investigated whether aprotin...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.24108
更新日期:2009-02-15 00:00:00
abstract::A case of granulocytic sarcoma involving the uterine cervix as primary manifestation without evidence of leukemia is presented. It was followed by neurological symptoms 19 months later and a right breast mass 26 months after the initial cervical lesion, but still with no evidence of leukemia. Two years and four months...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3030::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-09-15 00:00:00
abstract::Fourteen patients with advanced salivary gland malignancies were treated with combination chemotherapy. Five of 13 patients responded to cyclophosphamide and adriamycin and two patients in the responding groups underwent further potentially curable treatment, rendering them disease-free. Three patients with mucoepider...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19821201)50:11<2261::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Patients with advanced cancer often experience fatigue and other symptoms that negatively impact their quality of life. The current trial investigated the effect of melatonin on fatigue and other symptoms in patients with advanced cancer. METHODS:Patients who were aged ≥18 years, had a histologically confir...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.29563
更新日期:2015-10-15 00:00:00
abstract::The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as "slight" and "marked." The 39% frequency in the marked infiltration group at the mucosal stage di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901101)66:9<2012::aid-cncr2820
更新日期:1990-11-01 00:00:00
abstract::Nineteen postmenopausal patients with metastatic breast cancer refractory to conventional combination chemotherapy were treated with monthly cycles with the combinations of vinblastine, adriamycin, thiotepa and halotestin. Ten patients (52%) responded with a greater than 50% regression of measurable tumor. The median ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2534::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract::Ninety-four patients with lymphoma involving the extradural space with spinal cord compression proven at the time of laminectomy were reviewed. There were about three times as many patients with non-Hodgkin's lymphoma than with Hodgkin's disease. The majority of those with Hodgkin's disease had a proven histologic dia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197610)38:4<1862::aid-cncr282038
更新日期:1976-10-01 00:00:00
abstract::Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically eva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900401)65:7<1596::aid-cncr2820
更新日期:1990-04-01 00:00:00
abstract::Eighty-seven previously untreated patients with pathologic Stage IA, II (A or B), or IIIA Hodgkin's disease were randomized over a 48-month period to receive either megavoltage extended field radiotherapy alone or megavoltage radiotherapy limited to involved lymph node sites (including at least an upper mantle field) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197504)35:4<1055::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:The current study was performed to describe frequencies and risk factors of altered oral health and odontogenesis in childhood cancer survivors. METHODS:In total, 9308 survivors who were diagnosed between 1970 and 1986 and 2951 siblings from the Childhood Cancer Survivor Study completed a survey that contai...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24670
更新日期:2009-12-15 00:00:00
abstract::The authors report three patients who developed fatal respiratory failure after limited or unilateral thoracic radiation therapy for neoplasms. The respiratory failure was characteristic of the adult respiratory distress syndrome (ARDS) with refractory hypoxemia and diffuse bilateral infiltrates including areas of lun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860515)57:10<1941::aid-cncr282
更新日期:1986-05-15 00:00:00
abstract::A case of osteosarcoma arising in the soft tissue of the larynx in an elderly man is presented with light and electron microscopic documentation. The patient developed chronic hoarseness and a recurring polypoid laryngeal tumor, causing acute airway obstruction. He was treated by total laryngectomy, but he died with m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197811)42:5<2343::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:Recent advances in the early detection of prostatic adenocarcinoma have stimulated interest in the development of techniques for determining metastatic potential. METHODS:One hundred cases of adenocarcinoma, including 66 biopsy and radical prostatectomy specimens; 20 biopsies alone; and 14 transurethral res...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931115)72:10<3020::aid-cncr282
更新日期:1993-11-15 00:00:00
abstract::Twenty patients with locally advanced and/or metastatic transitional cell cancer of the urinary tract were treated with cyclophosphamide 500 mg/m2, Adriamycin (doxorubicin) 40 mg/m2 and cis-platinum (CDDP) 40 mg/m2 given every three weeks for 2 cycles, alternating with methotrexate 40 mg/m2 weekly for six weeks (CAP-M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<1::aid-cncr2820510
更新日期:1983-01-01 00:00:00
abstract::The properties of two classes of nonhistone nuclear proteins (NHNP) whose appearance has been correlated with the process of carcinogenesis in the colonic epithelium of rats given 1,2-dimethylhydrazine (DMH) have been investigated. NHNP isolated from adenocarcinomas of the colon were tested for their binding to homolo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197711)40:5+<2584::aid-cncr28204
更新日期:1977-11-01 00:00:00
abstract::The authors report on five patients with secondary leukemia (SL) and one of the "specific" chromosomal rearrangements usually encountered in de novo acute nonlymphoblastic leukemia: inv(16), t(15;17), t(8;21), and t(9;11). They were characterized by solid tumor as the primary malignancy in four of five cases, absence ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2505::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract:BACKGROUND:Endocrine therapy resistance is a major cause of distant recurrence (DR) in hormone receptor-positive breast cancer. This study evaluated differences in survival after DR in patients treated with different adjuvant endocrine therapy regimens in the Breast International Group (BIG) 1-98 trial. METHODS:BIG 1-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33318
更新日期:2020-12-08 00:00:00
abstract::Available information suggests that individuals with breast cancer gain weight during adjuvant treatment and that this weight gain may be associated with poor prognosis. Exploration of the factors which affect weight gain may aid in developing weight control interventions for these patients. To determine the factors w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910401)67:7<1954::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11231
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Novel approaches to increasing the therapeutic efficacy of targeted radiotherapy of cancer are required. One strategy to achieve this goal is to induce high-level expression of a receptor on the surface of tumor cells that can be targeted with a radiolabeled peptide. The objectives of this study were to 1) i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10300
更新日期:2002-02-15 00:00:00
abstract:BACKGROUND:Although p53 and HER-2/neu overexpression are found in 30% of breast carcinomas in women of all ages and are associated with high rates of lymph node metastases, their role in women age < 30 years has not been studied extensively. METHODS:The institutional breast cancer data base was searched to identify yo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20850
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Circulating immune complexes (CIC) have been implicated as a cause of malignancy-associated immunosuppression and disease progression. Previous attempts to remove CIC by pheresis or immunoadsorption over a Staphylococcus aureus protein A column have resulted in a few clinical responses, however the relations...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19950415)75:8<2099::aid-cncr2820
更新日期:1995-04-15 00:00:00
abstract:BACKGROUND:To evaluate the pathologic characteristics of the primary tumor relative to local control, survival, and freedom from distant metastases, an analysis was performed of 172 patients with ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive breast ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19930415)71:8<2532::aid-cncr2820
更新日期:1993-04-15 00:00:00