Intrahepatic mitomycin C as a salvage treatment for patients with hepatic metastases from colorectal carcinoma.

Abstract:

:Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (PR) to IH M and ten (16%) patients had stable disease. Patients who responded to IH FUDR were more likely to respond to IH M when compared with those who progressed on IH FUDR (47% versus 13%, respectively; P = 0.013). Those who were switched to IH M because of hepatotoxicity on IH FUDR also were more likely to respond to IH M than those who were switched because of progression on IH FUDR (75% versus 27%, respectively; P = 0.022). Baseline laboratory values, the percent of tumorous liver involvement, prior history of systemic chemotherapy, and the interval from diagnosis to initiation of IH M did not help predict response. Toxicity was mild and well tolerated. The overall median survival time of the 64 evaluable patients was 9.0 months from the start of IH M therapy. We conclude that IH M has some salvage benefit in patients with hepatic metastases.

journal_name

Cancer

journal_title

Cancer

authors

Schneider A,Kemeny N,Chapman D,Niedzwiecki D,Oderman P

doi

10.1002/1097-0142(19891201)64:11<2203::aid-cncr282

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

2203-6

issue

11

eissn

0008-543X

issn

1097-0142

journal_volume

64

pub_type

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