Abstract:
:Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (PR) to IH M and ten (16%) patients had stable disease. Patients who responded to IH FUDR were more likely to respond to IH M when compared with those who progressed on IH FUDR (47% versus 13%, respectively; P = 0.013). Those who were switched to IH M because of hepatotoxicity on IH FUDR also were more likely to respond to IH M than those who were switched because of progression on IH FUDR (75% versus 27%, respectively; P = 0.022). Baseline laboratory values, the percent of tumorous liver involvement, prior history of systemic chemotherapy, and the interval from diagnosis to initiation of IH M did not help predict response. Toxicity was mild and well tolerated. The overall median survival time of the 64 evaluable patients was 9.0 months from the start of IH M therapy. We conclude that IH M has some salvage benefit in patients with hepatic metastases.
journal_name
Cancerjournal_title
Cancerauthors
Schneider A,Kemeny N,Chapman D,Niedzwiecki D,Oderman Pdoi
10.1002/1097-0142(19891201)64:11<2203::aid-cncr282subject
Has Abstractpub_date
1989-12-01 00:00:00pages
2203-6issue
11eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
杂志文章相关文献
CANCER文献大全abstract::A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3107::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11899
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:Tobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients. METHODS:A structured tobacco assessment was incorporated into the electronic heal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28440
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:It is believed that in the early stages of hepatocarcinogenesis, some adenomatous hyperplasias (AH) progress to early hepatocellular carcinoma (eHCC), and that many eHCC develop into overt hepatocellular carcinoma (HCC) through nodule-in-nodule formation. However, the proliferative activity of these small no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940115)73:2<289::aid-cncr28207
更新日期:1994-01-15 00:00:00
abstract::Systemic aspergillosis is encountered with increasing prevalence in immunocompromised patients undergoing chemotherapy. The current communication describes the clinical and postmortem findings in three leukemic patients who developed myocardial infarction secondary to Aspergillus embolization of the coronary arteries....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861101)58:9<2146::aid-cncr2820
更新日期:1986-11-01 00:00:00
abstract::Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840715)54:2<274::aid-cncr28205
更新日期:1984-07-15 00:00:00
abstract:BACKGROUND:The objective of the current study was to investigate the effects and the morbidities of single-fraction stereotactic radiation therapy (SRT) for lung tumors. METHODS:A Microtron device was modified to deliver stereotactic irradiation under respiratory gating. Between August 1998 and December 2004, 59 malig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21747
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Androgen receptor blocking agents have become an established form of therapy for men with disseminated prostate carcinoma. The purpose of this study was to evaluate markers of bone turnover and to measure bone mineral densities (BMD) in men with disseminated prostate carcinoma treated with combined androgen ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Adenocarcinomas of the appendix represent a heterogeneous disease depending on the presence of mucinous histology, histologic grade, and stage. In the current study, the authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set. METHODS:Patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29744
更新日期:2016-01-15 00:00:00
abstract::The pancreatographic appearance and the clinical presentation of ten patients presenting with adenocarcinoma of the head of the pancreas coexisting with chronic pancreatitis were compared with those of 45 patients with chronic pancreatitis (CP), without malignancy, investigated at the same time period. All ten patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900215)65:4<893::aid-cncr28206
更新日期:1990-02-15 00:00:00
abstract::Selective adsorption of several common "monospecific" HLA typing sera with HLA typed platelets, purified B lymphocytes, cultured lymphoid cells, or lymphocytes from patients with active chronic lymphocytic leukemia demonstrated that many of these sera contain antibodies to non-HLA antigens. Antibodies were detected to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197706)39:6<2348::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:To retrospectively evaluate the significance of morphologic examination and ancillary studies performed on bilateral bone marrow biopsy specimens, 1864 bone marrow samples were studied. METHODS:Bilateral bone marrow biopsy specimens included 883 specimens that were evaluated for involvement by non-Hodgkin l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10364
更新日期:2002-03-01 00:00:00
abstract::A single dose of N-nitrosobis(2-oxopropyl)amine, a carcinogen for hamster pancreas, was administered to hamsters with regenerating pancreas 60 hours after initiation of regeneration when the maximum number of acinar cells are in S phase of the cell cycle. This led to nucleolar segregation and mitotic abnormalities fro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6+<1552::aid-cncr282
更新日期:1981-03-15 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:A series of retrospective studies have reported that patients with human epidermal growth factor receptor 2(HER2)-positive breast cancer are at a greater risk of central nervous system (CNS) metastases. Trastuzumab, which does not cross the blood-brain barrier, has been associated with this increased risk. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25771
更新日期:2011-05-01 00:00:00
abstract::Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1809::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::Fifty patients with inoperable squamous carcinoma of the lung. 38 with extensive, and 12 with limited disease, were treated with BACON. Tumor regression greater than 50% was observed in 17 patients (45%) with extensive, and four patients (33%) with limited disease. Stabilization of disease for greater than or equal to...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197603)37:3<1237::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1180::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatment...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32547
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome-wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. METHODS:Thirty-three tissue samples were analyzed: they included sa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31930
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physi...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.28783
更新日期:2014-09-15 00:00:00
abstract::Prior studies have shown that black patients with breast cancer have poorer survival times compared with white patients even when adjusted for stage. Seventy-four black patients treated on six Piedmont Oncology Association (POA) protocols were compared with 74 randomly selected white patients treated with the same pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910601)67:11<2850::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract::In a cohort of 254,417 male Swedish farmers (4,330,717 person-years) the incidence of cancer of the respiratory organs was compared to a reference cohort of 1,725,845 men (30,131,664 person-years) employed in other economic activities than agriculture or forestry. In the study cohort 1450 cases of cancer in the respir...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<1055::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11531
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:Monoclonal antibodies have not been evaluated in metastasizing endocrine tumors, even though these lesions may induce severe morbidity of hormone excess in absence of considerable tumor burden. METHODS:A murine monoclonal antibody of the IgG2a subtype was generated by immunization with dispersed tumor cells...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940301)73:5<1346::aid-cncr2820
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Most cases of granulosa cell tumor of the ovary are characterized by relatively good outcome; however, some tumors behave aggressively, and some tend to recur many years after the initial diagnosis. Because DNA ploidy has been shown to predict biologic behavior better than conventional prognostic variables i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950501)75:9<2295::aid-cncr2820
更新日期:1995-05-01 00:00:00
abstract::Skin cancers originating in areas of chronic injury (Marjolin's ulcers) are thought to behave in a more aggressive fashion than those due to other causes. The initial surgical treatment, especially the management of the regional lymph nodes, remains controversial. This review of 37 patients with Marjolin's ulcer evalu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830701)52:1<173::aid-cncr28205
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. METHODS:The cancer cell dissociation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950315)75:6+<1554::aid-cncr282
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:Metastatic renal cell cancer is associated with poor long-term survival and has no cure. Traditional clinical endpoints are best supplemented by patient-reported outcomes designed to assess symptoms and function. Normative data was obtained on the National Comprehensive Cancer Network-Functional Assessment o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27688
更新日期:2013-01-15 00:00:00