Abstract:
:A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carcinocythemia is probably due to widespread infiltration of many bone marrow sites and may also be related to splenectomy, which may impair reticuloendothelial clearance of circulating tumor cells. The differential diagnosis of carcinocythemia from superimposed acute myelogenous leukemia, which can complicate radiotherapy and chemotherapy for the primary tumor, is discussed. Cytomorphology, histochemistry, and electron microscopy of abnormal circulating cells should aid in the distinction of these two processes.
journal_name
Cancerjournal_title
Cancerauthors
Myerowitz RL,Edwards PA,Sartiano GPdoi
10.1002/1097-0142(197712)40:6<3107::aid-cncr282040subject
Has Abstractpub_date
1977-12-01 00:00:00pages
3107-11issue
6eissn
0008-543Xissn
1097-0142journal_volume
40pub_type
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