Abstract:
BACKGROUND:Benign and malignant pancreatic mucinous tumors differ in proliferative activity, production of tumor markers, and expression of growth factors. DNA ploidy is a useful index of aggressiveness and poor survival in ductal adenocarcinoma, but has not been studied in pancreatic cystic tumors. METHODS:The DNA ploidy status of Fuelgen-stained tissue sections of pancreatic mucinous cystic tumors was evaluated by image cytometry and related to clinical outcome obtained by case record review. RESULTS:Ploidy status correlated with malignancy and poor clinical outcome. All benign mucinous cystadenomas (n = 13) were diploid and cured by resection. Patients with diploid cystadenocarcinomas (n = 6) had an 83% survival rate following resection, while patients with aneuploid cystadenocarcinomas (n = 5) all died (four of disease and the fifth of another cause). The difference in survival between the diploid and aneuploid carcinomas was significant (P = 0.04). CONCLUSIONS:DNA ploidy status of pancreatic mucinous tumors by image analysis provides quantifiable information that may be predictive of clinical outcome. DNA aneuploidy appears to be a significant differential factor in pancreatic mucinous tumors and is associated with shortened survival in mucinous cystadenocarcinomas.
journal_name
Cancerjournal_title
Cancerauthors
Southern JF,Warshaw AL,Lewandrowski KBdoi
10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCRsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
58-62issue
1eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCRjournal_volume
77pub_type
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