A pathologic study of childhood lymphoma in Taiwan with special reference to peripheral T-cell lymphoma and the association with Epstein-Barr viral infection.


:The authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. Southern blot hybridization was also performed in 23 cases to study their association with Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (HTLV-1). The 65 cases included 56 non-Hodgkin's lymphoma (NHL) (86%) and 9 Hodgkin's disease (HD) (14%). The NHL could be classified into the following groups: Group I, small noncleaved cell lymphoma (20 cases); Group II, lymphoblastic lymphoma (17 cases); Group III, large cell lymphoma (17 cases); and miscellaneous (2 cases). There was no follicular lymphoma case. Immunohistochemical study on paraffin sections and/or frozen specimens in 47 cases of NHL showed that all the Group I cases belonged to B-cell neoplasm (17 of 17 cases); most of the Group II cases belonged to T-cell neoplasm (9 of 14 cases); and most of the Group III cases were peripheral T-cell lymphoma (PTL) (8 of 16 cases), including 2 cases of Ki-1 lymphoma. The majority of childhood NHL belonged to high-grade malignancy with an aggressive clinical course (median survival time, 8 months). The EBV DNA could be detected from the tumor tissues in 4 of 6 PTL, but in none of the remaining 19 cases of NHL including 6 Burkitt's type lymphomas. HTLV-1 proviral genome was not detected in all specimens examined. The authors concluded that the distribution pattern and clinicopathologic feature of childhood lymphoma in Taiwan are comparable to that in Japan and western countries. The frequent association of EBV with aggressive PTL was unique and deserves additional investigation.






Lee SH,Su IJ,Chen RL,Lin KS,Lin DT,Chuu WM,Lin KS




Has Abstract


1991-11-01 00:00:00














  • Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma.

    abstract:BACKGROUND:Diagnosis of nasopharyngeal carcinoma (NPC) at an early disease stage is important for successful treatment and improving the outcome of patients. The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer. METHODS:Serum samples were applied to meta...


    pub_type: 杂志文章


    authors: Ho DW,Yang ZF,Wong BY,Kwong DL,Sham JS,Wei WI,Yuen AP

    更新日期:2006-07-01 00:00:00

  • Infants younger than 1 year of age with rhabdomyosarcoma.

    abstract::Of a total of 1561 patients registered in the Intergroup Rhabdomyosarcoma Study (IRS) as of May 1983, 78 patients (5%) were younger than 1 year of age. These infants did not differ from the older children (1-20 years of age) in male/female ratio, clinical grouping, or survival rates. Infants younger than 1 year of age...


    pub_type: 杂志文章


    authors: Ragab AH,Heyn R,Tefft M,Hays DN,Newton WA Jr,Beltangady M

    更新日期:1986-12-15 00:00:00

  • Favorable prognosis after late relapse of Hodgkin's disease.

    abstract:BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...


    pub_type: 杂志文章


    authors: Garcia-Carbonero R,Paz-Ares L,Arcediano A,Lahuerta J,Bartolome A,Cortes-Funes H

    更新日期:1998-08-01 00:00:00

  • An aggressive approach to marginally resectable lung cancer.

    abstract::Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...


    pub_type: 杂志文章


    authors: Sherman DM,Neptune W,Weichselbaum R,Order SE,Piro AJ

    更新日期:1978-05-01 00:00:00

  • Chemotherapy for metastatic Merkel cell carcinoma. Review of the M.D. Anderson Hospital's experience.

    abstract::Thirteen patients with regional or distant metastases from Merkel cell carcinoma were treated with combination chemotherapy. Three patients had a complete response to therapy. In two patients with nodal disease the duration of response was 10+ and 4+ years. In addition, three patients had a partial response, and six p...


    pub_type: 杂志文章,评审


    authors: Feun LG,Savaraj N,Legha SS,Silva EG,Benjamin RS,Burgess MA

    更新日期:1988-08-15 00:00:00

  • Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies.

    abstract:BACKGROUND:Retrospective studies suggest that dose intensity is an important determinant of outcome in the treatment of patients with a variety of malignant diseases such as breast cancer, ovarian cancer, and lymphoma. Unfortunately, these results have not been clearly substantiated in prospective randomized trials. On...


    pub_type: 杂志文章


    authors: Long GD,Negrin RS,Hoyle CF,Kusnierz-Glaz CR,Schriber JR,Blume KG,Chao NJ

    更新日期:1995-09-01 00:00:00

  • An assessment of World Health Organization criteria for severe acute respiratory syndrome in patients with cancer.

    abstract:BACKGROUND:The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or to...


    pub_type: 杂志文章


    authors: Gu J,Wu A,Li J,Zhang X,Fang J,Li M,Yao Y,Ke Y,Gu J,Chen M,You W

    更新日期:2004-04-01 00:00:00

  • Survival results in adult patients treated for medulloblastoma.

    abstract::The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...


    pub_type: 杂志文章


    authors: Hazuka MB,DeBiose DA,Henderson RH,Kinzie JJ

    更新日期:1992-04-15 00:00:00

  • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S.

    abstract:BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...


    pub_type: 杂志文章


    authors: Yuan JM,Govindarajan S,Arakawa K,Yu MC

    更新日期:2004-09-01 00:00:00

  • Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood.

    abstract::Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...


    pub_type: 杂志文章


    authors: Lobel JS,O'Brien RT,McIntosh S,Aspnes GT,Capizzi RL

    更新日期:1979-03-01 00:00:00

  • Ultrasound-guided transcutaneous Tru-Cut biopsy to diagnose laryngopharyngeal masses: a pilot study.

    abstract:BACKGROUND:Patients with bulky laryngopharyngeal masses and a relative or absolute contraindication to general anesthesia present diagnostic difficulties. In the current study, the authors assessed the utility of transcutaneous ultrasound-guided Tru-Cut biopsy (USGTCB) under local anesthesia in such individuals. METHO...


    pub_type: 杂志文章


    authors: Ansarin M,De Fiori E,Preda L,Maffini F,Bruschini R,Calabrese L,Jereczek-Fossa BA,Chiesa F,Bellomi M

    更新日期:2007-06-01 00:00:00

  • Metaanalysis of the accuracy of rapid prescreening relative to full screening of pap smears.

    abstract:BACKGROUND:Efficient quality assurance and improvement measures are essential ingredients in a well organized cytology-based program for cervical carcinoma screening. Various pap smear review procedures, aiming for optimization of accuracy, are described throughout the literature. Evaluation and synthesis of those meth...


    pub_type: 杂志文章,meta分析


    authors: Arbyn M,Schenck U,Ellison E,Hanselaar A

    更新日期:2003-02-25 00:00:00

  • The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: an analysis of 147 cases.

    abstract:BACKGROUND:Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS:For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers...


    pub_type: 杂志文章


    authors: Nakanishi Y,Ochiai A,Yoshimura K,Kato H,Shimoda T,Yamaguchi H,Tachimori Y,Watanabe H,Hirohashi S

    更新日期:1998-04-15 00:00:00

  • Fine-needle aspiration of thyroid nodules: correlation between cytology and histology and evaluation of discrepant cases.

    abstract:BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...


    pub_type: 杂志文章


    authors: Sidawy MK,Del Vecchio DM,Knoll SM

    更新日期:1997-08-25 00:00:00

  • CEA-like material in cytosols from human breast carcinomas. Correlation with biochemical and pathologic parameters.

    abstract::CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...


    pub_type: 杂志文章


    authors: Duffy MJ,O'Connell M,O'Sullivan F,McKenna B,Allen MA,McDonnell L

    更新日期:1983-01-01 00:00:00

  • Wilms' tumor in adolescence.

    abstract::Two cases of Wilms' tumor in adolescent males are presented. The clinical and radiographic findings were unusual and both presented atypical gross and microscopic features that could be correlated with the radiographic findings. Histologic examination of both tumors showed evidence of tubular and glomerular maturation...


    pub_type: 杂志文章


    authors: Merten DF,Yang SS,Bernstein J

    更新日期:1976-03-01 00:00:00

  • Preoperative chemotherapy for giant cell carcinoma of the thyroid.

    abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...


    pub_type: 杂志文章


    authors: Spanos GA,WolK D,Desner MR,Khan A,Platt N,Khafif RA,Cortes EP

    更新日期:1982-12-01 00:00:00

  • A familial occurrence of natural killer cell--T-lymphocyte proliferation disease in two children.

    abstract::Several reports describe the association of hyperlymphocytosis with neutropenia. This syndrome, named lymphoproliferative disease, is characterized by a chronic indolent clinical course, bone marrow lymphocyte infiltration, and granulopenia of central origin. The proliferating lymphocytes share large granular lymphocy...


    pub_type: 杂志文章


    authors: Le Deist F,de Saint Basile G,Coulombel L,Breton-Gorius J,Maier-Redelsperger M,Beljorde K,Bremard C,Griscelli C

    更新日期:1991-05-15 00:00:00

  • Influence of delay to diagnosis on prognostic indicators of screen-detected breast carcinoma.

    abstract:BACKGROUND:Although delay to diagnosis after a breast screening abnormality causes anxiety, its effect on prognosis is unknown. METHODS:Using pooled data from five Canadian organized breast cancer screening programs, the authors used unconditional logistic regression to evaluate the effect of delay to diagnosis on pro...


    pub_type: 杂志文章


    authors: Olivotto IA,Gomi A,Bancej C,Brisson J,Tonita J,Kan L,Mah Z,Harrison M,Shumak R

    更新日期:2002-04-15 00:00:00

  • Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: correlation with biopsy follow-up results.

    abstract:BACKGROUND:The aim of this study was to examine p16(INK4a) protein expression in ThinPrep (Cytyc Corporation, Marlborough, Mass) cervical specimens by using the CINtec p16(INK4a) Cytology Kit (Dako, Glostrup, Denmark). The ability of this assay to accurately identify underlying high-grade lesions was assessed by using ...


    pub_type: 杂志文章


    authors: Meyer JL,Hanlon DW,Andersen BT,Rasmussen OF,Bisgaard K

    更新日期:2007-04-25 00:00:00

  • Efficacy of follow-up bone scans in carcinoma of the prostate.

    abstract::Three hundred fifteen radioisotopic bone scans ranging from initial scan only to nine scans per patient, performed on 114 patients with adenocarcinoma of the prostate between 1979 and 1984, were reviewed. Seventeen patients had positive scans, ten on initial scan and seven at follow-up. Nine patients had bone pain at ...


    pub_type: 杂志文章


    authors: Corrie D,Timmons JH,Bauman JM,Thompson IM

    更新日期:1988-06-15 00:00:00

  • Chemotherapy of advanced breast cancer: a randomized trial of vincristine, Adriamycin, and cyclophosphamide (VAC) versus cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP).

    abstract::Fifty-one patients with metastatic breast cancer were randomly allocated to receive either a four drug combination consisting of cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP), or a combination of vincristine, Adriamycin, and cyclophosphamide (VAC) with cross-over on relapse. Objective responses...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Carmo-Pereira J,Costa FO,Henriques E

    更新日期:1981-10-01 00:00:00

  • Carcinoid tumors in Denmark 1978-1989 and the risk of subsequent cancers. A population-based study.

    abstract:BACKGROUND:Previous studies have suggested an excess cancer risk in patients with carcinoid tumors. This association was reexamined using truly population-based data. METHODS:By means of data from the Danish Cancer Registry all carcinoid tumors diagnosed in Denmark between 1978 and 1989 were identified. All patients w...


    pub_type: 杂志文章


    authors: Westergaard T,Frisch M,Melbye M

    更新日期:1995-07-01 00:00:00

  • Binding of soybean agglutinin lectin to prostatic hyperplasia and adenocarcinoma.

    abstract::The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight ...


    pub_type: 杂志文章


    authors: Loy TS,Kyle J,Bickel JT

    更新日期:1989-04-15 00:00:00

  • Nickel-related cancers of the respiratory tract.

    abstract::Nickel-related cancers of the respiratory tract have been recognized for nearly 50 years and represent a unique opportunity for prevention among refinery workers. Studies of exposed employees have been conducted in which evaluations were made of the histopathologic changes in the respiratory mucosa and the body burden...


    pub_type: 杂志文章


    authors: Barton RT,Hogetveit AC

    更新日期:1980-06-15 00:00:00

  • The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience.

    abstract:BACKGROUND:It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS:The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblas...


    pub_type: 杂志文章


    authors: McGregor LM,Rao BN,Davidoff AM,Billups CA,Hongeng S,Santana VM,Hill DA,Fuller C,Furman WL

    更新日期:2005-12-15 00:00:00

  • Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients.

    abstract:BACKGROUND:The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma. METHODS:Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institution...


    pub_type: 杂志文章,多中心研究


    authors: Shikama N,Ogawa K,Tanaka S,Toita T,Nakamura K,Uno T,Ohnishi H,Itami J,Tada T,Saeki N

    更新日期:2005-07-01 00:00:00

  • Calcium metabolism in cancer. Studies using calcium isotopes and immunoassays for parathyroid hormone and calcitonin.

    abstract::Studies of calcium metabolism in 38 patients with cancer indicated that: 1) intestinal absorption of calcium was reduced in patients with skeletal metastases and in those with hypercalcemia; 2) calcium-47 space (a measurement of bone turnover rate) was high in the patients with skeletal metastases; 3) hypercalcemic pa...


    pub_type: 杂志文章


    authors: Coombes RS,Ward MK,Greenberg PB,Hillyard CJ,Tulloch BR,Morrison R,Joplin GF

    更新日期:1976-11-01 00:00:00

  • Predictive value of oncogenic driver subtype, programmed death-1 ligand (PD-L1) score, and smoking status on the efficacy of PD-1/PD-L1 inhibitors in patients with oncogene-driven non-small cell lung cancer.

    abstract:BACKGROUND:This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors....


    pub_type: 杂志文章


    authors: Ng TL,Liu Y,Dimou A,Patil T,Aisner DL,Dong Z,Jiang T,Su C,Wu C,Ren S,Zhou C,Camidge DR

    更新日期:2019-04-01 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy and paraparesis: remission with chemotherapy. A case report.

    abstract::A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...


    pub_type: 杂志文章


    authors: Haas RJ,Helmig MS,Prechtel K

    更新日期:1978-07-01 00:00:00