A simple rapid autoradiography for 3H-thymidine labeling index and its application to therapy of adult acute leukemia.

abstract：:Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA di...

journal_title：Cancer

authors： Olszewski W,Darzynkiewicz Z,Rosen PP,Schwartz MK,Melamed MR

更新日期：1981-08-15 00:00:00

abstract：:Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...

journal_title：Cancer

authors： Offit K,Macris NT,Hellman G,Rotterdam HZ

更新日期：1986-01-15 00:00:00

abstract：BACKGROUND:Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were aske...

journal_title：Cancer

authors： Mauz-Körholz C,Gorde-Grosjean S,Hasenclever D,Shankar A,Dörffel W,Wallace WH,Schellong G,Robert A,Körholz D,Oberlin O,Hall GW,Landman-Parker J

更新日期：2007-07-01 00:00:00

abstract：:The clinical, morphologic, and immunohistochemical features of 5 cases of peripheral T-cell lymphoma with lymph node and skin involvement are reported. All patients were male and presented with generalized lymphadenopathy and skin lesions. Lymph node biopsy specimens showed a diffusely growing, pleomorphic, atypical l...

journal_title：Cancer

authors： van den Oord JJ,De Wolf-Peeters C,Frizzera G,Desmet VJ,Tricot G,Thomas J,Marien K,Gatter KC,Mason DY

更新日期：1985-04-15 00:00:00

abstract：BACKGROUND:In multidisciplinary assessment clinics for screen-detected breast lesions, onsite cytopathologists provide immediate results of fine-needle aspiration biopsies (FNABs) and this information is used for patient counseling and treatment planning. Such consultation is not possible for the increasing proportion ...

journal_title：Cancer

authors： Farshid G,Pieterse S

更新日期：2006-06-25 00:00:00

abstract：BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires...

journal_title：Cancer

authors： Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NF

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...

journal_title：Cancer

authors： Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

更新日期：2010-06-15 00:00:00

abstract：:Treatment choices for localized prostate cancer appear to vary widely, although it is unclear whether this variation is a result of patient values or other factors. The authors conducted a systematic review of the literature, identifying 70 articles that focused on prostate cancer decision making. Studies suggest that...

journal_title：Cancer

authors： Zeliadt SB,Ramsey SD,Penson DF,Hall IJ,Ekwueme DU,Stroud L,Lee JW

更新日期：2006-05-01 00:00:00

abstract：:Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity...

journal_title：Cancer

authors： Marks LB

更新日期：1990-12-15 00:00:00

abstract：BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...

journal_title：Cancer

authors： Kantarjian HM,Jabbour EJ,Garcia-Manero G,Kadia TM,DiNardo CD,Daver NG,Borthakur G,Jain N,Waukau JB,Kwari MI,Ravandi F,Anderson BD,Iizuka K,Jin C,Zhang C,Plunkett WK

更新日期：2019-05-15 00:00:00

abstract：:Fourteen examples of intravenous leiomyomatosis in the FIP files were studied. Growth beyond the uterus occurred in 10 of the 14 examples, largely in vessels in the broad ligament and in uterine and iliac veins. Metastasis to the heart occurred in 1 example. The study provides evidence that is consistent with both the...

journal_title：Cancer

authors： Norris HJ,Parmley T

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) signaling is a target for antiangiogenic cancer therapy. The authors have previously observed that up to 40% of vessels in colorectal carcinoma (CRC) tumors are negative for VEGF receptor 2 (VEGFR2) expression. Differential activity of transforming growth factor beta...

journal_title：Cancer

authors： Kuczynski EA,Viloria-Petit AM,Coomber BL

更新日期：2011-12-15 00:00:00

abstract：:Ewing's sarcoma is a small cell malignant tumor that usually arises in the medullary cavity of bone. Less frequently, it originates in soft tissue and may secondarily invade underlying bone. The origin of Ewing's sarcoma in a periosteal location without extension into either the bone or adjacent soft tissue has not be...

journal_title：Cancer

authors： Bator SM,Bauer TW,Marks KE,Norris DG

更新日期：1986-10-15 00:00:00

abstract：BACKGROUND:Malignant fibrous histiocytoma (MFH) is a neoplasm of late adult life and often is reported in the pediatric population. It is thought to behave more benignly in children than in adults. METHOD:Clinical and pathologic features, treatment, and outcome of nine pediatric patients seen at British Columbia's Chi...

journal_title：Cancer

authors： Cole CH,Magee JF,Gianoulis M,Rogers PC

更新日期：1993-06-15 00:00:00

abstract：:The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

journal_title：Cancer

authors： Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

更新日期：1990-02-15 00:00:00

abstract：BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data for the years 1973-1992 documented that patients age < 50 years presented with more advanced disease. Because of the increase in the incidence rate of lung adenocarcinoma in the past few decades and the presentation of more advanced disease in young pat...

journal_title：Cancer

authors： Liu NS,Spitz MR,Kemp BL,Cooksley C,Fossella FV,Lee JS,Hong WK,Khuri FR

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:To enhance the efficacy of chemotherapy for medullary thyroid carcinoma (MTC), we evaluated the effect of combining radioimmunotherapy (RAIT) with 90Y-anticarcinoembryonic antigen (CEA) monoclonal antibody MN-14 and chemotherapy in nude mice bearing human MTC xenografts. A preliminary study evaluated doxorub...

journal_title：Cancer

authors： Stein R,Chen S,Reed L,Richel H,Goldenberg DM

更新日期：2002-01-01 00:00:00

abstract：:The disposition of many drugs in obesity is altered, although little is known of the effect of obesity on the pharmacokinetics of anti-cancer drugs. In this report the authors describe the pharmacokinetics of high-dose methotrexate in an obese woman (184% ideal body weight) with osteosarcoma. For this patient, both th...

journal_title：Cancer

authors： Fleming RA,Eldridge RM,Johnson CE,Stewart CF

更新日期：1991-09-15 00:00:00

abstract：BACKGROUND:Breast cancer is the second most common source of brain metastasis. Stereotactic radiosurgery (SRS) can be an effective treatment for some patients with brain metastasis (BM). Necrosis is a common feature of many brain tumors, including BM; however, the influence of tumor necrosis on treatment efficacy of SR...

journal_title：Cancer

authors： Xu Z,Marko NF,Angelov L,Barnett GH,Chao ST,Vogelbaum MA,Suh JH,Weil RJ

更新日期：2012-03-01 00:00:00

abstract：:A case of multiple myeloma is described that contained two morphologically identical but immunologically diverse subpopulations. One of the subclones produced only kappa chains, whereas the other contained only gamma chains. Additional immunohistologic investigations revealed production by one of the subpopulations of...

journal_title：Cancer

authors： Metz K,Leder LD

更新日期：1985-09-15 00:00:00

abstract：BACKGROUND:Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Scr...

journal_title：Cancer

authors： Rice K,Sharma K,Li C,Butterly L,Gersten J,DeGroff A

更新日期：2019-02-15 00:00:00

abstract：:A new Hodgkin's cell line, designated HD-70, was established from the peripheral blood of a 69-year-old man with Hodgkin's disease of nodular sclerosing type. The cell line grows in a single cell suspension and has a doubling time of 28 hours. The cells have a round or irregular nucleus or multiple nuclei in relativel...

journal_title：Cancer

authors： Kanzaki T,Kubonishi I,Eguchi T,Yano S,Sonobe H,Ohyashiki JH,Ohyashiki K,Toyama K,Ohtsuki Y,Miyoshi I

更新日期：1992-02-15 00:00:00

abstract：:Historically coal mining populations have been reported to have elevated stomach cancer incidence rates. To identify which factors might be associated with cases who reside in these high risk areas, and specifically if particulate exposures from coal mining and coal utilization are associated with risk, a mining area ...

journal_title：Cancer

authors： Weinberg GB,Kuller LH,Stehr PA

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Although flow cytometry (FCM) has become a widely used technique for the measurement of DNA content in solid tumors, the correlation of ploidy analysis by FCM with cytogenetic analysis (CGA) is not well described. The sensitivities of G-banded CGA and FCM were compared to determine the accuracy of the DNA in...

journal_title：Cancer

authors： Dressler LG,Duncan MH,Varsa EE,McConnell TS

更新日期：1993-09-15 00:00:00

abstract：BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...

journal_title：Cancer

authors： Wilder RB,Romaguera JE,Tucker SL,Ha CS,Hess MA,Cabanillas F,Cox JD

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein enzyme that extends telomere specific repeats on the ends of chromosomes. Telomerase activity has been detected frequently in various types of human tumors and has been associated with cell immortality and oncogenesis. Human telomerase reverse transcriptase (hTERT), a telome...

journal_title：Cancer

authors： Tomoda R,Seto M,Tsumuki H,Iida K,Yamazaki T,Sonoda J,Matsumine A,Uchida A

更新日期：2002-09-01 00:00:00

abstract：:The National Cancer Institute (NCI) has increased its emphasis in cancer prevention by undertaking a number of human intervention trials. Special emphasis is placed on chemoprevention, diet, and smoking and tobacco use. Some 24 clinical trials are ongoing in chemoprevention to assess the role of specific chemicals (na...

journal_title：Cancer

authors： Cullen JW

更新日期：1988-10-15 00:00:00

abstract：:During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median...

journal_title：Cancer

authors： Nisce LZ,Safai B,Kim JH

更新日期：1981-03-01 00:00:00

abstract：:The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy. Response (PR + CR) was obtained in 14 patients (40%) of a median duration of five months. Among the 14 responding patients, 10 were resistant to previous endocrine th...

journal_title：Cancer

authors： Mouridsen HT,Kristensen D,Nielsen JH,Dombernowsky P

更新日期：1980-07-15 00:00:00

abstract：:The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...

journal_title：Cancer

authors： Burotto M,Chiou VL,Lee JM,Kohn EC

更新日期：2014-11-15 00:00:00