Abstract:
BACKGROUND:Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were asked to report their experience of surgery alone used in the treatment of pediatric LPHL. METHODS:Data from 58 patients were collected by the French Society for Pediatric Cancers, the German-Austrian Pediatric Study Group/German Society of Pediatric Oncology and Hematology (Germany), and the Children's Cancer and Leukaemia Group (United Kingdom). In total, there were 50 boys and 8 girls, and the median age was 11 years (age range, 4-17 years). Fifty-four patients had stage IA disease, 2 patients had stage IIA disease, and 2 patients had stage IIIA disease. RESULTS:With a median follow-up of 43 months (range, 2-202 months), the overall survival rate was 100%, and the progression-free survival (PFS) rate was 57%. Fifty-one of 58 patients achieved complete remission (CR) after surgery. In the CR group, the overall PFS rate was 67% (95% confidence interval, 51-82%). All seven patients who had residual disease after initial surgery developed recurrences (P = .003). Among 18 patients with stage IA LPHL who developed recurrent disease, 11 patients had local recurrences, and 7 patients recurred in stage IIA. One patient with stage IIIA disease presented with high-grade B-cell non-Hodgkin lymphoma at 10 years of follow-up. CONCLUSIONS:When complete resection was achieved, a substantial proportion of patients with surgically treated, early-stage LPHL experienced long-term remission and actually may have been cured.
journal_name
Cancerjournal_title
Cancerauthors
Mauz-Körholz C,Gorde-Grosjean S,Hasenclever D,Shankar A,Dörffel W,Wallace WH,Schellong G,Robert A,Körholz D,Oberlin O,Hall GW,Landman-Parker Jdoi
10.1002/cncr.22762subject
Has Abstractpub_date
2007-07-01 00:00:00pages
179-85issue
1eissn
0008-543Xissn
1097-0142journal_volume
110pub_type
杂志文章相关文献
CANCER文献大全abstract::Twenty-six cases of anaplastic thyroid tumor were investigated and reclassified using immunoperoxidase techniques. Sections of the neoplasms were stained immunohistologically for the following thyroid associated antigens: (1) thyroglobulin, which shows a positive reaction with follicular cells of the thyroid; (2) calc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880715)62:2<319::aid-cncr28206
更新日期:1988-07-15 00:00:00
abstract::The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<2105::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract::The clinical and pathologic characteristics of 17 small carcinomas (less than 2 cm in diameter) of the pancreas are reviewed in this article. All the tumors were located in the head of the pancreas, and the clue to the diagnosis was jaundice in ten patients and abdominal pain in seven. Carcinoembryonic antigen (CEA) a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880701)62:1<135::aid-cncr28206
更新日期:1988-07-01 00:00:00
abstract::Clinicians can shed new light on the genetic and environmental origins of cancer, particularly multiple primary malignancies, by asking additional questions at the bedside. Areas to explore include occupational history, personal habits, residence, and medical and family histories with emphasis on subtle clues of disor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4+<1867::aid-cncr28204
更新日期:1977-10-01 00:00:00
abstract::Two consecutive trials for the treatment of childhood non-Hodgkin's lymphoma were evaluated, carried out by the same cooperative groups. Group A: From June, 1973 to December, 1975, 50 evaluable patients under 16 years of age participated in a study that included vincristine and prednisone plus surgery and/or radiother...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19841215)54:12<2863::aid-cncr282
更新日期:1984-12-15 00:00:00
abstract::In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This ar...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19931201)72:11+<3484::aid-cncr28
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-12-25 00:00:00
abstract::Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197903)43:3<1089::aid-cncr282043
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:This study was performed to determine the incidence of central venous device-related blood stream infection and thrombosis in patients treated with moderate dose continuous-infusion interleukin-2 (IL-2). METHODS:The records of 160 consecutive patients treated at the University of Wisconsin Hospital and Clin...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-02-15 00:00:00
abstract:BACKGROUND:Despite improvements in survival rates, cancer treatments have significant side effects that affect the quality of life of children and their families. When an ill child cannot self-report symptoms (eg, he or she is too ill), caregiver (parent) reporting becomes critical. This study evaluates the validity an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33389
更新日期:2020-12-17 00:00:00
abstract::The current study determines the prognostic factors after hepatectomy for hepatocellular carcinomas. The 295 patients who underwent hepatectomy from 1973 through 1987 were included for a univariate and a Cox multivariate analysis. The favoring conditions were determined as follows. The essential requirements are (1) t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1104::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Some patients with gastric carcinoma experience local disease recurrence despite undergoing curative resection of the tumor and regional lymph nodes (LNs), suggesting the presence of occult micrometastases. To evaluate the presence of gastric carcinoma micrometastasis in patients with otherwise histologicall...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2056::aid-cncr1545
更新日期:2001-10-15 00:00:00
abstract::Mitomycin C (MMC) has been evaluated in combination with several antitumor agents. Full dose response curves were established for all drugs and drug combinations. Synergy was shown with MMC plus either cyclophosphamide (CYC) or methotrexate (MTX). In testing MMC and CYC against P388 leukemia, the combined treatment yi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830215)51:4<600::aid-cncr28205
更新日期:1983-02-15 00:00:00
abstract::Forty-four cases of skin and soft tissue angiosarcoma seen at M. D. Anderson Hospital before 1976 were reviewed. The cases fell into six different clinical groups: scalp-face, 17 cases; postmastectomy, 14 cases; postradiation, 5 cases; leg with vascular stasis, 2 cases; breast, 2 cases; and miscellaneous, 4 cases. In ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811015)48:8<1907::aid-cncr2820
更新日期:1981-10-15 00:00:00
abstract:BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28261
更新日期:2013-10-15 00:00:00
abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative stud...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19980615)82:12<2299::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in the epidemiology of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). METHODS:Cancer registry data from 1988-2000 were linked with AIDS registry data...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21562
更新日期:2006-01-01 00:00:00
abstract::Clinical and histological correlates of survival in patients undergoing complete resection of pulmonary metastases from nonseminomatous testicular carcinoma were determined in 25 Stage C patients aged 17-38 years treated from 1969-1978. All patients had orchiectomy and retroperitoneal lymphadenectomy. Nineteen patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1152::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract:BACKGROUND:In Japan, where liver transplantation has not been used to treat patients with hepatocellular carcinoma (HCC), percutaneous ethanol injection (PEI) has been employed for those with small HCCs that are not amenable to surgical resection. In the current study, the authors evaluated PEI as a treatment for HCC p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991101)86:9<1682::aid-cn
更新日期:1999-11-01 00:00:00
abstract::Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2353::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract::The records were reviewed for all patients hospitalized at a pediatric oncology center for complications of leukemia (n = 822) or lymphoma (n = 290) during an 8-year period. The results of surveillance cultures (throat, rectal, and urine) and blood cultures were analyzed to identify cases of Candida tropicalis and C. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910801)68:3<594::aid-cncr28206
更新日期:1991-08-01 00:00:00
abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<84::aid-cncr282049
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The current study was designed to evaluate the efficacy and toxicity of the continuous oral administration of a combination of cyclophosphamide (50 mg/day given in the morning) and dexamethasone (1 mg/day given in the evening) in patients with prostate specific antigen (PSA) progression despite single or mul...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11713
更新日期:2003-10-15 00:00:00
abstract:BACKGROUND:Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12
更新日期:2000-06-15 00:00:00
abstract::The use of prostate-specific antigen (PSA) as a screening test remains controversial. There have been several attempts to refine PSA measurements to improve its predictive value. These modifications, including PSA density, PSA kinetics, and the measurement of PSA isoforms, have met with limited success. Therefore, com...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24357
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Currently, there is very low-quality evidence available regarding benefit of surgical resection of the primary tumor (SRPT), in patients with stage IV colorectal cancer (CRC). In the absence of randomization, the reported benefit may reflect selection of younger and healthier patients with good performance s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28464
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The use of docetaxel prolongs survival for patients with castrate-resistant prostate cancer (CRPC). Inhibition of vascular endothelial growth factor (VEGF) with bevacizumab may further enhance the antitumor effect of docetaxel and estramustine in patients with CRPC. METHODS:This cooperative group trial enro...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25421
更新日期:2011-02-01 00:00:00
abstract::Two children with cancer that persisted after multiple exploratory laparotomies, external beam radiation therapy, and multidrug chemotherapy had gold 198 (198Au) seeds implanted into their localized but unresectable tumor. Both children are alive, are receiving no therapy, and are disease-free more than 2 years later....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860301)57:5<951::aid-cncr28205
更新日期:1986-03-01 00:00:00
abstract::Sixty-three gastrectomy specimens (21 with early intestinal type carcinoma, 21 with early diffuse carcinoma, and 21 with benign nonneoplastic lesions) were examined histochemically to determine the distribution of intestinal metaplasia (IM), particularly the sulphomucin-secreting type (Type IIB IM). The frequency and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900815)66:4<689::aid-cncr28206
更新日期:1990-08-15 00:00:00