Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood.

abstract：:The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...

journal_title：Cancer

authors： Odom LF,Wilson H,Cullen J,Bank J,Blake M,Jamieson B

更新日期：1990-10-15 00:00:00

abstract：BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...

journal_title：Cancer

authors： Manolitsas TP,Wain GV,Williams KE,Freidlander M,Hacker NF

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Nineteen patients with Ewing sarcoma of bone, each younger than 3 years of age at the time of initial presentation, are reported. These children represent an unusually young age group for documented Ewing sarcoma and represent 2.6% of all patients registered in the Intergroup Ewing's Sarcoma Study (IESS). M...

journal_title：Cancer

authors： Maygarden SJ,Askin FB,Siegal GP,Gilula LA,Schoppe J,Foulkes M,Kissane JM,Nesbit M

更新日期：1993-03-15 00:00:00

abstract：BACKGROUND:We recently reported that peroxisome proliferator-activated receptor γ agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5. Here in the ACTIM phase 2 clinical trial, we asked whether pioglitazone add-on therapy to imatinib would impact CML residua...

journal_title：Cancer

authors： Rousselot P,Prost S,Guilhot J,Roy L,Etienne G,Legros L,Charbonnier A,Coiteux V,Cony-Makhoul P,Huguet F,Cayssials E,Cayuela JM,Relouzat F,Delord M,Bruzzoni-Giovanelli H,Morisset L,Mahon FX,Guilhot F,Leboulch P,French

更新日期：2017-05-15 00:00:00

abstract：:One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received s...

journal_title：Cancer

authors： Lederman GS,Sheldon TA,Chaffey JT,Herman TS,Gelman RS,Coleman CN

更新日期：1987-08-15 00:00:00

abstract：BACKGROUND:Uterine serous carcinoma (USC) is not recognized as part of any defined hereditary cancer syndrome, and its association with hereditary breast and ovarian carcinoma and Lynch syndrome are uncertain. METHODS:Using targeted capture and massively parallel genomic sequencing, 151 subjects with USC were assessed...

journal_title：Cancer

authors： Pennington KP,Walsh T,Lee M,Pennil C,Novetsky AP,Agnew KJ,Thornton A,Garcia R,Mutch D,King MC,Goodfellow P,Swisher EM

更新日期：2013-01-15 00:00:00

abstract：:A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologi...

journal_title：Cancer

authors： Kamesaki H,Koya M,Miwa H,Kita K,Doi S,Tatsumi E,Hatanaka M,Uchino H

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...

journal_title：Cancer

authors： Ennis RD,Katz AE,de Vries GM,Heitjan DF,O'Toole KM,Rubin M,Buttyan R,Benson MC,Schiff PB

更新日期：1997-06-15 00:00:00

abstract：BACKGROUND:Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross-sectional study of the long-term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon. METHODS:Seven hundred thirty-nine patients who were treat...

journal_title：Cancer

authors： Glendenning JL,Barbachano Y,Norman AR,Dearnaley DP,Horwich A,Huddart RA

更新日期：2010-05-15 00:00:00

abstract：:Peanut agglutinin (PNA) receptors were studied in 37 cases of reactive follicular hyperplasia and 66 follicular lymphomas, using the unlabeled peroxidase-antiperoxidase (PAP) method on paraffin embedded material. Based on the binding sites of the lectin, positively stained cells were easily recognized as either cytopl...

journal_title：Cancer

authors： Ree HJ,Hsu SM

更新日期：1983-05-01 00:00:00

abstract：:Data from the Cancer Registry in the Netherlands Antilles made clear that the incidence rate of cancer of the upper digestive tract in this country was among the highest in the world. To study the long-term trends in the incidence rate a retrospective population-based case-finding survey was performed. The author pres...

journal_title：Cancer

authors： Freni SC

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextran-coated charcoal method (DCC). Immunocytochemical assays (ICA) for ER are more recent and have been executed mostly on frozen sections with the monoclonal antibody H222...

journal_title：Cancer

authors： Pertschuk LP,Feldman JG,Kim YD,Braithwaite L,Schneider F,Braverman AS,Axiotis C

更新日期：1996-06-15 00:00:00

abstract：BACKGROUND:Many histologic classifications of thymic epithelial tumors have been reported to date, but to the authors' knowledge, none of them closely reflect the clinical behavior or prognosis of the tumor. Therefore, it is necessary to establish a biologic marker for thymic epithelial tumors. Variants of CD44 may be ...

journal_title：Cancer

authors： Sonobe S,Miyamoto H,Nobukawa B,Izumi H,Futagawa T,Ishikawa N,Yamazaki A,Uekusa T,Abe H,Suda K

更新日期：2005-05-15 00:00:00

abstract：:Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...

journal_title：Cancer

authors： Buzdar AU,Legha SS,Luna MA,Tashima CK,Hortobagyi GN,Blumenschein GR

更新日期：1980-01-15 00:00:00

abstract：BACKGROUND:The current study sought to delineate prospectively the rates and clinical course of emotional distress, cognitive impairment, and quality of life (QOL) in chemotherapy-naive patients with cancer and to consider the determinants of global QOL. METHODS:Patients who consented to participate were administered ...

journal_title：Cancer

authors： Iconomou G,Mega V,Koutras A,Iconomou AV,Kalofonos HP

更新日期：2004-07-15 00:00:00

abstract：BACKGROUND:The purpose of this article was to evaluate the utility of a pharmacokinetically modeled measure of regional contrast access, based on dynamic contrast-enhanced magnetic resonance imaging (MRI) studies after preoperative chemotherapy, as a predictor of disease free survival in osteosarcoma. METHODS:The kine...

journal_title：Cancer

authors： Reddick WE,Wang S,Xiong X,Glass JO,Wu S,Kaste SC,Pratt CB,Meyer WH,Fletcher BD

更新日期：2001-06-15 00:00:00

abstract：:The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...

journal_title：Cancer

authors： Grasso M,Buonaguidi A,Mondina R,Borsellino G,Lania C,Banfi G,Rigatti P

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND:The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS:Computed tomography (CT) scans before and after therapy were reviewed in 4...

journal_title：Cancer

authors： Amer AM,Zaid M,Chaudhury B,Elganainy D,Lee Y,Wilke CT,Cloyd J,Wang H,Maitra A,Wolff RA,Varadhachary G,Overman MJ,Lee JE,Fleming JB,Tzeng CW,Katz MH,Holliday EB,Krishnan S,Minsky BD,Herman JM,Taniguchi CM,Das P,

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. METHODS:The records of 36 patients with brain metastases from esophageal carcinoma who were treated between 1986 a...

journal_title：Cancer

authors： Ogawa K,Toita T,Sueyama H,Fuwa N,Kakinohana Y,Kamata M,Adachi G,Saito A,Yoshii Y,Murayama S

更新日期：2002-02-01 00:00:00

abstract：:To assess the efficacy of performing both computed tomography (CT) of the thorax and upper abdomen and whole-body gallium scintigraphy for staging lung cancer, the results of each test were compared with those obtained by chest radiography and clinical examination in 100 patients. Clinical efficacy was defined in term...

journal_title：Cancer

authors： MacMahon H,Scott W,Ryan JW,Montner SM,Little AG,Hoffman PC,Ferguson MK,Golomb HM

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprot...

journal_title：Cancer

authors： Ogbureke KU,Abdelsayed RA,Kushner H,Li L,Fisher LW

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Neuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF-induced cell proliferation, in pancreatic carcinoma cell lines ...

journal_title：Cancer

authors： Li M,Yang H,Chai H,Fisher WE,Wang X,Brunicardi FC,Yao Q,Chen C

更新日期：2004-11-15 00:00:00

abstract：:Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...

journal_title：Cancer

authors： Exelby PR

更新日期：1980-04-01 00:00:00

abstract：:The value of the serum level of carcinoembryonic antigen (CEA) as an indicator of recurrent colorectal carcinoma has been accepted, and the use of serial CEA levels to monitor postoperative chemotherapy has been suggested, However, elevated CEA levels may be associated with nonneoplastic conditions, of which the most ...

journal_title：Cancer

authors： Savrin RA,Martin EW Jr

更新日期：1981-02-01 00:00:00

abstract：:An unusual tumor of the cystic duct in a 28-year-old woman is described. The patient presented with a painful distended gallbladder due to a small tumor occluding the cystic duct. Microscopically the tumor cells showed a nesting pattern suggestive of endocrine differentiation, but contained numerous lipid vacuoles and...

journal_title：Cancer

authors： Goodman ZD,Albores-Saavedra J,Lundblad DM

更新日期：1984-02-01 00:00:00

abstract：:To evaluate the frequency, etiology, and outcome of diffuse interstitial pneumonitis after treatment of children with Stage IV (favorable histologic type) Wilms' tumor using whole-lung and abdominal radiation therapy, and combination chemotherapy, all cases reported in such patients entered on National Wilms' Tumor St...

journal_title：Cancer

authors： Green DM,Finklestein JZ,Tefft ME,Norkool P

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Malignant fibrous histiocytoma (MFH) is a neoplasm of late adult life and often is reported in the pediatric population. It is thought to behave more benignly in children than in adults. METHOD:Clinical and pathologic features, treatment, and outcome of nine pediatric patients seen at British Columbia's Chi...

journal_title：Cancer

authors： Cole CH,Magee JF,Gianoulis M,Rogers PC

更新日期：1993-06-15 00:00:00

abstract：:In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The tumor volume doubling times (TV); obtained by me...

journal_title：Cancer

authors： von Fournier D,Weber E,Hoeffken W,Bauer M,Kubli F,Barth V

更新日期：1980-04-15 00:00:00

abstract：BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...

journal_title：Cancer

authors： Seidinger AL,Mastellaro MJ,Paschoal Fortes F,Godoy Assumpção J,Aparecida Cardinalli I,Aparecida Ganazza M,Correa Ribeiro R,Brandalise SR,Dos Santos Aguiar S,Yunes JA

更新日期：2011-05-15 00:00:00

abstract：:The authors treated 32 patients with Stage IIIB or IV non-small cell lung cancer (NSCLC) with an outpatient regimen of edatrexate (10-ethyl-10-deaza-aminopterin) (10-EdAM) on days 1 and 8, cyclophosphamide on day 1, and cisplatin on day 1, repeated every 3 weeks with dose modification. The 22 men and 10 women (median ...

journal_title：Cancer

authors： Lee JS,Libshitz HI,Fossella FV,Murphy WK,Pang AC,Lippman SM,Shin DM,Dimery IW,Glisson BS,Hong WK

更新日期：1991-09-01 00:00:00