Abstract:
BACKGROUND:The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS:Computed tomography (CT) scans before and after therapy were reviewed in 4 cohorts: cohort 1 (99 patients with stage I/II PDAC who received neoadjuvant chemoradiation and surgery); cohort 2 (86 patients with stage IV PDAC who received chemotherapy), cohort 3 (94 patients with stage I/II PDAC who received protocol-based neoadjuvant gemcitabine chemoradiation), and cohort 4 (47 patients with stage I/II PDAC who received neoadjuvant chemoradiation and were prospectively followed in a registry). The tumor/parenchyma interface was visually classified as either a type I response (the interface remained or became well defined) or a type II response (the interface became poorly defined) after therapy. Consensus (cohorts 1-3) and individual (cohort 4) visual scoring was performed. Changes in enhancement at the interface were quantified using a proprietary platform. RESULTS:In cohort 1, type I responders had a greater probability of achieving a complete or near-complete pathologic response (21% vs 0%; P = .01). For cohorts 1, 2, and 3, type I responders had significantly longer disease-free and overall survival, independent of traditional covariates of outcomes and of baseline and normalized cancer antigen 19-9 levels. In cohort 4, 2 senior radiologists achieved a κ value of 0.8, and the interface score was associated with overall survival. The quantitative method revealed high specificity and sensitivity in classifying patients as type I or type II responders (with an area under the receiver operating curve of 0.92 in cohort 1, 0.96 in cohort 2, and 0.89 in cohort 3). CONCLUSIONS:Changes at the PDAC/parenchyma interface may serve as an early predictor of response to therapy. Cancer 2018;124:1701-9. © 2018 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
journal_name
Cancerjournal_title
Cancerauthors
Amer AM,Zaid M,Chaudhury B,Elganainy D,Lee Y,Wilke CT,Cloyd J,Wang H,Maitra A,Wolff RA,Varadhachary G,Overman MJ,Lee JE,Fleming JB,Tzeng CW,Katz MH,Holliday EB,Krishnan S,Minsky BD,Herman JM,Taniguchi CM,Das P,doi
10.1002/cncr.31251subject
Has Abstractpub_date
2018-04-15 00:00:00pages
1701-1709issue
8eissn
0008-543Xissn
1097-0142journal_volume
124pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::The incidence of gastric cancer has declined markedly in Finland during the last 4 decades. To document the changes caused by that in the ratio of the intestinal type (IT) to the diffuse type (DT) of gastric carcinoma we compared the 367 cases diagnosed from southwestern Finland at the Department of Pathology, Turku U...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930515)71:10<2926::aid-cncr282
更新日期:1993-05-15 00:00:00
abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040
更新日期:1984-08-15 00:00:00
abstract::Three bleomycin-resistant (BLMr) human carcinoma cell lines (HeLa-BLMr, KB-BLMr, and Hepd-uvBLMr) were established in culture by progressively increasing the concentration of bleomycin (BLM). HeLa-BLMr and KB-BLMr were obtained after 5 and 2 months of incubation with BLM, whereas the establishment of Hepd-uvBLMr requi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880415)61:8<1501::aid-cncr2820
更新日期:1988-04-15 00:00:00
abstract::Venous thromboembolism (VTE) is a frequent complication of cancer and cancer treatment and is associated with multiple clinical consequences, including recurrent VTE, bleeding, and an increase in the risk of death. Although the risks associated with VTE have been well recognized in surgical cancer patients, there is a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24665
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were cond...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25096
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930401)71:7<2299::aid-cncr2820
更新日期:1993-04-01 00:00:00
abstract::A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbeari...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831215)52:12<2201::aid-cncr282
更新日期:1983-12-15 00:00:00
abstract:BACKGROUND:False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS:The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31271
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20571
更新日期:2004-10-15 00:00:00
abstract:BACKGROUND:Meticulous selection of patients for esophageal cancer surgery is critical, because major surgical intervention can cause considerable consequences. For this study, the authors explored their institution's large surgical experience to examine the impact of age on long-term patient survival and surgical compl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24488
更新日期:2009-10-01 00:00:00
abstract::Thrombocytosis above 40.0 X 10(4)/mm3 occurred in five of six (83%) patients with malignant mesothelioma. In contrast, the incidence of thrombocytosis was 7.5% in patients with lung adenocarcinoma, 12.5% in squamous cell carcinoma, 5.1% in small cell carcinoma, and 41.7% in large cell carcinoma, respectively. The plat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1699::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract::In order to search for the histogenesis and progression of colorectal cancer, the background mucosas of 18 patients with a single colorectal cancer, apart from familial adenomatosis coli, were studied by a step sectioning method. Three early minute cancers (3-5 mm in diameter) were detected in the apparently normal mu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880215)61:4<829::aid-cncr28206
更新日期:1988-02-15 00:00:00
abstract::Ninety-two cases of granulosa cell tumor of the ovary have been studied. The clinical and pathologic data from this group were similar to that obtained in previous series. Because of the long natural history of many granulosa cell tumors, crude death rates over a relatively short period give little indication of the t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197501)35:1<231::aid-cncr2820350
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Telomerase activity and telomere length have been shown to be involved in the control of cell proliferation and regulation of cell senescence. The expression of telomerase activity may endow cells with the capacity of unlimited proliferation and immortality. The authors examined the telomerase activity and t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001115)89:10<2092::aid-cncr9>3
更新日期:2000-11-15 00:00:00
abstract::The relationships between cigarette smoking, occupational exposures, dietary vitamin A and lung cancer is explored in a case-control study. The study is based on 1002 primary lung cancers among white men and 1119 white male controls between 35 and 79 years of age admitted to Roswell Park Memorial Institute from 1957 t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<910::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:Modified nucleosides such as 1-methyl-adenosine and pseudouridine exist as minute components of transfer ribonucleic acid (tRNA) and are excreted in the urine in large amounts in the presence of malignancy. Although use of these modified nucleosides as tumor markers has long been studied and many reports hav...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931215)72:12<3571::aid-cncr282
更新日期:1993-12-15 00:00:00
abstract:BACKGROUND:Cancer cell expression of costimulatory molecule B7-H1 has been implicated as a potent inhibitor of T-cell-mediated antitumoral immunity. The authors recently reported that B7-H1 is aberrantly expressed in primary renal cell carcinoma (RCC). Blockade of B7-H1, as demonstrated in several murine cancer models,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21470
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:An estimated 5-10% of all pancreatic adenocarcinomas have a hereditary association. The objective of the current study was to characterize the clinical and pathologic features of familial pancreatic carcinoma and to determine potential differences in demographics, risk factors, and outcomes between familial ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20700
更新日期:2004-12-15 00:00:00
abstract::Eighty-nine primary lung carcinomas and 23 metastatic lung tumors were immunohistochemically studied for the expression of pulmonary surfactant apoproteins, by using monoclonal (PE-10) and polyclonal antibodies. Surfactant apoprotein was demonstrated in the cytoplasm and/or nuclear inclusion bodies of only primary lun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880201)61:3<532::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract::Seventeen cases of intranasal epithelial tumors are reviewed. Thirteen were epithelial papillomas and four were squamous cell carcinomas associated with epithelial papillomas. In two cases followed over a 10 year period, transformation from an initial papilloma into a carcinoma was demonstrated. The histopathologic ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197612)38:6<2503::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract::The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197604)37:4<1869::aid-cncr282037
更新日期:1976-04-01 00:00:00
abstract::Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<743::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197502)35:2<450::aid-cncr2820350
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Transitional cell carcinoma (TCC) is rare in the female genital tract. Although it is most common in the ovary, small series of cases in the cervix have been reported, with isolated cases described in the fallopian tube, adnexa uteri, and endometrium. METHODS:Eight cases of primary TCC involving the endomet...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22410
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:The usefulness of fine-needle aspiration biopsy (FNAB) for the histologic subtyping of specific sarcomas still is somewhat controversial but is becoming increasingly popular in the U.S. METHODS:To determine the accuracy and usefulness of FNAB in the differential diagnosis of myxoid sarcoma, the authors retr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20000625)90:3<167::aid-cncr5>3.0
更新日期:2000-06-25 00:00:00
abstract:BACKGROUND:Ordinary craniopharyngiomas affecting sellar regions of children and preadolescents are composed of ameloblastomatous and/or squamous constituents. The authors encountered an autopsy case of a stillborn infant with a large craniopharyngioma with unusual manifestations. METHODS:The craniopharyngioma was anal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950615)75:12<2971::aid-cncr282
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:Patients affected by neurofibromatosis type 1 (NF1) are at higher risk of developing soft-tissue sarcomas (STS) than the general population. The clinical findings and outcome in 43 children and adolescents with NF1 treated for STS in the Italian protocols between 1988 and 2004 are reported. METHODS:The stud...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.22533
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00