Abstract:
:The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14 healthy control subjects. SHBG levels were significantly higher in patients with prostatic carcinoma (37.6 +/- 8.4 nmol/l) than in those with prostatic hyperplasia (24.5 +/- 5.2 nmol/l; P less than 0.05) or control subjects (14.9 +/- 2.8 nmol/l; P less than 0.01). It is not known why SHBG levels are higher in patients with carcinoma or hyperplasia of the prostate. The contradictory results obtained in other studies may be due to heterogeneity of the binding globulin causing its values to vary in the different assays used.
journal_name
Cancerjournal_title
Cancerauthors
Grasso M,Buonaguidi A,Mondina R,Borsellino G,Lania C,Banfi G,Rigatti Pdoi
10.1002/1097-0142(19900715)66:2<354::aid-cncr28206subject
Has Abstractpub_date
1990-07-15 00:00:00pages
354-7issue
2eissn
0008-543Xissn
1097-0142journal_volume
66pub_type
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