Abstract:
BACKGROUND:The use of docetaxel prolongs survival for patients with castrate-resistant prostate cancer (CRPC). Inhibition of vascular endothelial growth factor (VEGF) with bevacizumab may further enhance the antitumor effect of docetaxel and estramustine in patients with CRPC. METHODS:This cooperative group trial enrolled men with CRPC. Patients received oral estramustine 280 mg 3 times daily on Days 1 through 5 of every cycle plus 70 mg/m² docetaxel and 15 mg/kg bevacizumab on Day 2 every 3 weeks. Prostate-specific antigen (PSA) values were monitored every cycle, and imaging studies were obtained every 3 cycles. The primary endpoint was progression-free survival (PFS), and the secondary objectives were safety, PSA decline, measurable disease response, and overall survival. RESULTS:Seventy-nine patients were enrolled; and 77 patients received a median of 8 cycles and were evaluable. A 50% PSA decline was observed in 58 patients (75%). Twenty-three of 39 patients with measurable disease had a partial response (59%). The median PFS was 8 months, and the overall median survival was 24 months. Neutropenia without fever (69%), fatigue (25%), and thrombosis/emboli (9%) were the most common severe toxicities. Twenty-four of 77 patients were removed from protocol treatment because of disease progression, 35 of 77 patients were removed because of a physician or patient decision, and 15 patients were removed secondary to toxicity. CONCLUSIONS:The combination of docetaxel, estramustine, and bevacizumab was tolerable but complicated by toxicity. Although the endpoint of PFS did not meet the desired level, encouraging antitumor activity and overall survival were observed. Further phase 3 evaluation of the role of bevacizumab in CRPC is ongoing.
journal_name
Cancerjournal_title
Cancerauthors
Picus J,Halabi S,Kelly WK,Vogelzang NJ,Whang YE,Kaplan EB,Stadler WM,Small EJ,Cancer and Leukemia Group B.doi
10.1002/cncr.25421subject
Has Abstractpub_date
2011-02-01 00:00:00pages
526-33issue
3eissn
0008-543Xissn
1097-0142journal_volume
117pub_type
杂志文章,多中心研究相关文献
CANCER文献大全abstract:BACKGROUND:Although < 1% of men present with prostate-specific antigen (PSA)-negative prostate carcinoma, in that they have serum PSA levels much lower than the tumor burden would suggest, such patients represent a management dilemma. To the authors' knowledge, little information exists in the literature regarding patt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11821
更新日期:2003-12-01 00:00:00
abstract::Multiple independent tumors were identified in specimens from 117 of 234 prostatectomies for clinical adenocarcinoma; there were 266 incidental cancers in these 117 prostates. The clinically detected carcinoma was the largest (or only) tumor in all 202 Stage B cases. However, among 32 Stage A cases (detection by trans...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2313::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:The clinical dose of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro- sourea hydrochloride (ACNU) is limited by the bone marrow suppression it produces. The authors investigated whether bone marrow transplantation (BMT) associated with a high dose of ACNU could alleviate marrow toxicity ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930115)71:2<364::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract::Renal cell carcinoma (RCC) has remained refractory to substantive change of its natural history despite intervention with a number of therapeutic modalities. Alpha interferons leukocyte interferon alpha [HuIFN-alpha (Le)] and lymphoblastoid interferon alpha [HuIFN-alpha (Ly)] initially were shown to produce regression...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860415)57:8+<1696::aid-cncr282
更新日期:1986-04-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:There is controversy regarding the effect of age on breast carcinoma, and previous analyses have often excluded the most elderly patients as well as those with advanced cancers. This study assessed treatment variations and outcome in relation to age for a complete series of patients who presented with breast...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000115)88:2<369::aid-cnc
更新日期:2000-01-15 00:00:00
abstract::The efficacy of mitoxantrone in combination with vinblastine was assessed in 156 patients with metastatic breast cancer who had been treated previously with one or multiple chemotherapeutic regimens. Mitoxantrone was given by random assignment, either as a 10 mg/m2 single intravenous dose or in five consecutive daily ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19871015)60:8<1724::aid-cncr2820
更新日期:1987-10-15 00:00:00
abstract::Clinical trials are becoming increasingly difficult to carry out in the face of a changing health care delivery system. The reluctance of third party payers to reimburse for experimental therapy and the growing practice of providers to limit resources allocated for the care of cancer patients undergoing such therapies...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820671818
更新日期:1991-03-15 00:00:00
abstract::Trastuzumab is a monoclonal antibody used for the treatment of metastatic breast carcinoma in women whose tumors overexpress the HER2 protein. Cardiotoxicity has been reported to occur with trastuzumab when administered alone and in combination with antineoplastic agents, particularly anthracyclines. The risk of cardi...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.10854
更新日期:2002-10-01 00:00:00
abstract::The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts, including surgical oncologists, medical oncologists, path...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32874
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Six human pancreatic carcinoma cell lines, designated as KMP-1 to KMP-6, were established and maintained in vitro for > 3 years. All were derived from pancreatic ductal adenocarcinomas. The six cell lines originated from either primary pancreatic tumors, metastatic liver tumors, or metastases to lymph nodes....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990215)85:4<832::aid-cnc
更新日期:1999-02-15 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951115)76:10+<1992::aid-cncr28
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c
更新日期:1999-06-01 00:00:00
abstract::A 54-year-old man with hepatocellular carcinoma (HCC) of the typical trabecular pattern exhibiting unusual histologic features, both osteoid and bone formations, is reported. The tumor was associated with well-developed cirrhosis; thus, this may be different from mixed hepatic tumors of adults with bone formations bec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860101)57:1<134::aid-cncr28205
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc
更新日期:1997-12-25 00:00:00
abstract:BACKGROUND:Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that are relatively resistant to chemotherapy and for which more effective drug therapy is needed. METHODS:The 5 listed subtypes were enrolled into a single indolent s...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.30379
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were cond...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25096
更新日期:2010-06-01 00:00:00
abstract::Between 1970 and 1989, 17 children with histologically malignant intracranial ependymomas received treatment at the University of Pennsylvania (Philadelphia, PA). Eleven were treated with prophylactic cranial or craniospinal irradiation plus a local boost (CS-XRT), five with local (L-XRT) irradiation only, and one was...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910601)67:11<2766::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract::Autopsy data of 423 cases of primary tumor of the lung over a 36-year period were evaluated for the presence of gastrointestinal tract metastases. Fifty-eight cases (14%) were found and were analyzed for histologic nature of tumor, anatomic location, symptomatology and complications. The most common histologic type of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<170::aid-cncr28204
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Various methods of detecting cancer with fluorescence have been developed. One type of fluorescence is based on the tumor-localizing properties of certain dyes. However, the phototoxicity of most known tumor-localizing dyes hinders the safe use of such diagnostic methods. The authors have developed a fluores...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990401)85:7<1421::aid-cn
更新日期:1999-04-01 00:00:00
abstract::A case of basosquamous or so-called transitional cloacogenic carcinoma of the sigmoid colon, which arose above the pelvic brim at the peritoneal reflection, is reported. We were not able to find a report of this histologic type of tumor arising this far from the pectinate line of the anus, which is the most common pri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197709)40:3<1234::aid-cncr282040
更新日期:1977-09-01 00:00:00
abstract::The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was for...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811001)48:7<1633::aid-cncr2820
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoma (CRC) may be the most frequent form of hereditary cancer. Genetic counseling and testing for heritable CRC is a promising approach for reducing the high incidence and mortality rates associated with the disease. Patients with CRC or those with at least one family member with the disease ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010101)91:1<57::aid-cncr8>3.0.
更新日期:2001-01-01 00:00:00
abstract::A single dose of N-nitrosobis(2-oxopropyl)amine, a carcinogen for hamster pancreas, was administered to hamsters with regenerating pancreas 60 hours after initiation of regeneration when the maximum number of acinar cells are in S phase of the cell cycle. This led to nucleolar segregation and mitotic abnormalities fro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6+<1552::aid-cncr282
更新日期:1981-03-15 00:00:00
abstract::The survival of cervical carcinoma patients with paraaortic/high common iliac nodal metastases was evaluated by retrospective chart review during a 13-year interval. Thirty-three patients with cervical carcinoma and surgically documented nodal metastases received primary, extended-field radiation therapy. Overall 2-ye...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<251::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract::The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no hist...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820215)49:4<819::aid-cncr28204
更新日期:1982-02-15 00:00:00
abstract::The clinical course of a 33-year-old man with generalized lymphadenopathy bearing all physical, laboratory and histologic characteristics of "angio-immunoblastic lymphadenopathy with dysproteinemia" (AILD) is described. Therapy was without significant benefit and the patient died 22 months after initial diagnosis. At ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2183::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Breast cancers that are negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) (triple negative [TN]) have been associated with high-grade histology, aggressive clinical behavior, and poor survival. It has been determined that breast cancers that ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23243
更新日期:2008-02-15 00:00:00