Controlled-release morphine tablets in patients with chronic cancer pain: a narrative review of controlled clinical trials.

Abstract:

BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative studies with CR morphine tablets administered every 12 hours to patients with cancer pain. RESULTS:CR morphine tablets were uniformly effective; 98% of patients completed a treatment course of every-12-hours therapy. Although the effective analgesic dose varied considerably from study to study (range, 90-330 mg per day), pain was well controlled with CR morphine tablets as the primary analgesic. Mean pain scores, converted to a common 10-point scale, ranged from 1.1-2.9 across all studies. There was only occasional need for IR morphine rescue medication (range, 2-39 mg per day). The mean discontinuation rate because of side effects or lack of every-12-hours efficacy was 2%. In seven studies that used IR morphine as the comparative agent, CR morphine tablets were found to be equally effective as IR morphine. CONCLUSIONS:Twice-daily dosing of CR morphine provides convenient, safe, and effective relief of cancer pain.

journal_name

Cancer

journal_title

Cancer

authors

Warfield CA

doi

10.1002/(sici)1097-0142(19980615)82:12<2299::aid-c

subject

Has Abstract

pub_date

1998-06-15 00:00:00

pages

2299-306

issue

12

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19980615)82:12<2299::AID-C

journal_volume

82

pub_type

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