Abstract:
BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediated apoptosis. Thus, OPG may protect tumor cells from lymphocyte-mediated cytotoxicity and, as a result, contribute to tumor progression. In the current study, the authors investigated this hypothesis in patients with bladder carcinoma. METHODS:Serum OPG levels for 185 patients with bladder carcinoma were determined using an enzyme-linked immunosorbent assay. These levels then were assessed for potential correlations with various disease characteristics and outcome measures. RESULTS:The mean serum OPG concentration in patients with bladder carcinoma was approximately 3 times greater than the mean concentration in healthy individuals, and among patients with bladder carcinoma, higher tumor stage and grade were found to be associated with increased serum OPG levels. Within the subpopulation of patients with superficial bladder carcinoma, after a follow-up period of 5 years, those who had low serum OPG levels tended to have a longer postoperative tumor-free interval compared with those who had high serum OPG levels. Furthermore, among patients with muscle-invasive bladder carcinoma, the 5-year disease-specific survival rate was greater for those who had low serum OPG levels than for those who had high serum OPG levels. CONCLUSIONS:To the authors' knowledge, the current study is the first to demonstrate that serum OPG concentration is correlated with both tumor stage and tumor grade and that elevated serum OPG levels are predictive of early recurrence in patients with bladder carcinoma. These findings suggest that serum OPG concentration may have utility as a prognostic parameter in this setting.
journal_name
Cancerjournal_title
Cancerauthors
Mizutani Y,Matsubara H,Yamamoto K,Nan Li Y,Mikami K,Okihara K,Kawauchi A,Bonavida B,Miki Tdoi
10.1002/cncr.20550subject
Has Abstractpub_date
2004-10-15 00:00:00pages
1794-802issue
8eissn
0008-543Xissn
1097-0142journal_volume
101pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Cancer rates in immigrant populations are frequently found to be intermediate between the country of origin and the adopted country. Such observations play an important role in establishing the environmental origin of cancer. Chinese now constitute the third largest group immigrating to New York City. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940215)73:4<1270::aid-cncr2820
更新日期:1994-02-15 00:00:00
abstract:BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930715)72:2<389::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract:BACKGROUND:The reason for the thermal abnormality associated with some breast cancers is unclear. We previously reported that a thermographic abnormality is associated with tumor size and lymph node involvement. Despite this association, we were unable to demonstrate an independent association between an abnormal therm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960401)77:7<1324::AID-CN
更新日期:1996-04-01 00:00:00
abstract::In this report, the authors describe an innovative antitobacco advertising campaign in Arizona that was aimed at youth. The campaign utilizes traditional as well as non-traditional methods of research to determine the attitudes, behavior and values of today's adolescents. These creative methodologies led to rigorously...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19981215)83:12a+<2746::aid
更新日期:1998-12-15 00:00:00
abstract::Twelve Schwann cell tumors (two neurilemomas, six neurofibromas, and four malignant schwannomas), arising in the nasal cavity, paranasal sinuses or nasopharynx, are described. Schwann cell neoplasms only rarely develop in this area. Clinically, these tumors lead to nonspecific symptoms including nasal obstruction epis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2193::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract:BACKGROUND:Male breast cancer (MBC) is considered an androgen-dependent tumor, and as in prostatic cancer, responses have been reported with use of antiandrogens or gonadotropin-releasing hormone analogs. Thus, it is reasonable to postulate that better results could be achieved by combining these two agents. METHODS:E...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<502::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract::A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850201)55:3<598::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10371
更新日期:2002-03-01 00:00:00
abstract::This survey of the incidence of melanoma in New South Wales, Australia, from 1970 to 1976 revealed a doubling of incidence in the seven year period. The most marked rise occurred in 1972. A marked preponderance of leg melanoma in women and trunk melanoma in men was noted. The incidence of melanoma in men continues to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800715)46:2<427::aid-cncr28204
更新日期:1980-07-15 00:00:00
abstract:BACKGROUND:Adjustment disorders and major depression are common psychiatric disorders in patients with cancer and have a serious impact on quality of life. The problem in clinical oncology settings is underrecognition of these disorders; as a result, screening is recommended to detect them. The goal of the current stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11358
更新日期:2003-05-15 00:00:00
abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium-67 (67Ga) imagin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<577::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract:BACKGROUND:The authors evaluated the two indicators of metastatic proclivity (namely, virulence [V; the rate of appearance of distant metastases] and metastagenicity [M; the ultimate likelihood of developing distant metastases]) of breast carcinoma in elderly women. The authors then compared these characteristics with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20206
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Recombinant tumor necrosis factor-alpha (rTNF-alpha) is a highly potential antineoplastic agent. However, its systemic administration in humans has resulted in a life-threatening septic shock-like syndrome, and its use has been abandoned. The administration of high dose rTNF-alpha and melphalan via isolated ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970315)79:6<1129::aid-cn
更新日期:1997-03-15 00:00:00
abstract::From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910515)67:10<2506::aid-cncr282
更新日期:1991-05-15 00:00:00
abstract::The greatest decrease in breast cancer mortality is likely to derive from applying globally existing therapies at an earlier stage. A high priority of the World Health Organization (WHO) cancer control program is the outreach approach that promotes worldwide access to cancer therapies of proven values. Therefore, the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19900615)65:12<2803::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract::Chemotherapy for tumors of the central nervous system has a limited efficacy presumably because of restricted blood-brain barrier permeability. The advantage of regional intra-arterial administration of anticancer drugs is an increased uptake during the first passage of the drugs through tumor capillaries. Twenty pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910601)67:11<2844::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously shown an association with response to the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25211
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:The frequency of RET rearrangements (RET/PTC) in papillary thyroid carcinomas varies significantly according to geographic area, with the greatest incidence reported in the Belarus region, which is iodine-deficient and was contaminated severely after the Chernobyl reactor accident, and with the lowest incide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21270
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940301)73:5<1515::aid-cncr2820
更新日期:1994-03-01 00:00:00
abstract::Unnecessary, inappropriate, and futile care are given in all areas of health care including cancer care. Not only does such care increase costs and waste precious resources, but patients may have adverse outcomes when the wrong care is given. One of the ways to address this issue is to measure performance with the use...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980515)82:10+<2016::aid-
更新日期:1998-05-15 00:00:00
abstract:BACKGROUND:Previous investigators have detected shifts to lower stages at diagnosis for renal cell carcinoma and prostate cancer. The authors investigated whether a similar pattern is seen for urothelial carcinomas of the bladder, ureter, and renal pelvis and sought to identify changes in cancer grade and survival tren...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24147
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Periosteal osteosarcoma is a rare variant of osteosarcoma. Wide surgical removal is the mainstay of treatment, but controversy remains about the role of chemotherapy. The objective of this study was to review and analyze the clinical and treatment-related factors that influence the survival of patients with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25718
更新日期:2011-04-15 00:00:00
abstract::Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and blood samples were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2096::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-hour infusion. The maximum t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1097-0142(19960801)78:3<527::AID-CNC
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Through this study, the authors sought to investigate the biologic and immunologic effects of preoperative trastuzumab in patients with ductal carcinoma in situ (DCIS) of the breast. METHODS:Patients with DCIS were enrolled in this open-label phase 2 trial and tested for HER2. Trastuzumab was given by intra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25399
更新日期:2011-01-01 00:00:00
abstract::Balloon-mesh cytologic screening for esophageal cancer done in 255 asymptomatic high-risk United States veterans (age greater than 40 years, ethanol abuse for greater than 20 years, and cigarette smoking greater than 20 pack years) identified 37 patients with squamous cell dysplasia. Of the 37 patients with dysplasia,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900615)65:12<2731::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract:BACKGROUND:Myelodysplastic syndromes (MDS) appear to be underreported to cancer registries, with important implications for cancer and transfusion support service planning and delivery. Two population-based databases were linked to estimate MDS incidence more accurately. METHODS:Data from the statewide Victorian Cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28641
更新日期:2014-06-01 00:00:00
abstract::A case of a dermal nerve sheath myxoma arising in a digital nerve is reported. Similar tumors and its variants have been termed neurothekeoma, pacinian neurofibroma, bizarre cutaneous neurofibroma, and plexiform neurofibroma. The perineural sheath or the Schwann cell have been presumed to be the cell of origin by seve...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890315)63:6<1215::aid-cncr2820
更新日期:1989-03-15 00:00:00
abstract:BACKGROUND:Postchemotherapy surgery is an essential component in the management of patients with metastatic germ cell tumors (GCT). The authors assessed their institutional experience of retroperitoneal lymph node dissection (RPLND) after multiple chemotherapy regimens for advanced GCT. METHODS:By analyzing the instit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22440
更新日期:2007-02-01 00:00:00