Current role of gallium scan and magnetic resonance imaging in the management of mediastinal Hodgkin lymphoma.

Abstract:

BACKGROUND:A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium-67 (67Ga) imaging has been proven to be useful for the evaluation of HD in the mediastinum. The authors compared the ability of gallium scan and magnetic resonance imaging (MRI) to evaluate the mediastinal disease in the follow-up of patients with HD. METHODS:Thirty-four patients previously treated for HD were investigated with gallium scan, MRI, and all the other investigations to evaluate the mediastinal region. Sixteen patients were in restaging after treatment, and 18 were investigated for suspected radiologic recurrence in the mediastinum (follow-up, 9-75 months). The results of gallium scan and MRI were matched with clinical findings during the follow-up. RESULTS:A sensitivity of 85.7% for 67Ga and 92.8% for MRI was found, while the specificity was 100% for the scan and 80.6% for MRI. The predictive positive value that resulted was 100% for 67Ga and 68.4% for MRI. CONCLUSIONS:Both examinations were accurate in assessing the activity of residual masses in the mediastinum after treatment. 67Ga showed a lower sensitivity in comparison with MRI, but 67Ga frequently overestimates the presence of pathologic tissue. The authors acknowledge the complementary role of these two tests, but if only one of these examinations can be performed for logistic or economic reasons, then gallium scan represents the single most adequate diagnostic procedure.

journal_name

Cancer

journal_title

Cancer

authors

Gasparini MD,Balzarini L,Castellani MR,Tesoro Tess JD,Maffioli LS,Petrillo R,Ceglia E,Musumeci R,Buraggi GL

doi

10.1002/1097-0142(19930715)72:2<577::aid-cncr28207

subject

Has Abstract

pub_date

1993-07-15 00:00:00

pages

577-82

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

72

pub_type

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