Abstract:
BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneumothorax in 1, and radiologic tumor without effusion in 13. METHODS:Thoracoscopy was performed using a rigid thoracoscope under local anesthesia with neuroleptanalgesia. A total of 10-20 biopsies were taken from the parietal, diaphragmatic, and visceral pleura. Each diagnosis was confirmed by the French panel of mesothelioma pathologists. To prevent parietal seeding, radiation therapy at a dose of 21 Gy was administered during a period of 3 days to all points of entry. RESULTS:Tolerance to thoracoscopy was good. The only complications were subcutaneous emphysema (1 patient), local pleural infection (4 patients), hemorrhage of less than 100 ml (3 patients), and temperature of 38-38.5 degrees C (26 patients). In 137 patients, the cavity was free, and complete endoscopic inspection was achieved. In 51 patients, inspection was limited by adhesions that were severed to obtain biopsy. Nonspecific inflammation was observed in 12 patients (6.5%), nodules in 92 (49%), thickening in 21 (11%), and mixed lesions in 63 (33.5%). Diagnosis was achieved by thoracoscopy in 98% of patients, by fluid cytology in 26%, and by needle biopsy in 21%. CONCLUSION:In most patients, thoracoscopy allows complete visualization of the pleural cavity and provides high-quality biopsy samples. The diagnostic accuracy of thoracoscopy is similar to open thoracotomy, but the procedure is far less invasive, usually requiring that the patient remain in the hospital only 1 day.
journal_name
Cancerjournal_title
Cancerauthors
Boutin C,Rey Fdoi
10.1002/1097-0142(19930715)72:2<389::aid-cncr28207subject
Has Abstractpub_date
1993-07-15 00:00:00pages
389-93issue
2eissn
0008-543Xissn
1097-0142journal_volume
72pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract::Currently attention is focused on the testicle as a site of leukemic relapse. Leukemic involvement of the ovary has been described in several autopsy series with an incidence of 11-50% in patients with bone marrow relapse, but has rarely been reported during the clinical course of leukemia. In this report, four girls ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820801)50:3<587::aid-cncr28205
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Telomerase activity and telomere length have been shown to be involved in the control of cell proliferation and regulation of cell senescence. The expression of telomerase activity may endow cells with the capacity of unlimited proliferation and immortality. The authors examined the telomerase activity and t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001115)89:10<2092::aid-cncr9>3
更新日期:2000-11-15 00:00:00
abstract:BACKGROUND:There is no standard therapy for surgery- and radiotherapy-resistant, recurrent, low-grade spinal cord gliomas. Therefore, a retrospective study of temozolomide (TMZ) in adults with recurrent low-grade spinal cord gliomas with a primary objective of determining progression-free survival (PFS) was performed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23677
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS:Sixty-two patients with Stage IB-IV gastric/gastroesophageal a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20591
更新日期:2004-11-01 00:00:00
abstract::Six patients with Hodgkin's disease (HD) and demonstrable serum antibodies to human immunodeficiency virus (HIV) and two additional patients with HD belonging to HIV-associated high-risk groups but with negative HIV serology were studied. All patients were men and ranged in age from 21 to 45 years. The HIV risk factor...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910401)67:7<1865::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Age-related disparities in colon cancer treatment exist, with older patients being less likely to receive recommended therapy. However, to the authors' knowledge, few studies to date have focused on receipt of surgery. The objective of the current study was to describe patterns of surgery in patients aged ≥ ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27765
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32562
更新日期:2020-02-01 00:00:00
abstract::Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197808)42:2<570::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract::Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850201)55:3<561::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract::One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<772::aid-cncr28206
更新日期:1987-08-15 00:00:00
abstract::A 42-year-old man was admitted to the Cancer Division of the American MedicalCenter in February, 1956. He had been treated for erythrocytosis beginning 6 months previously, with reduction of his hemoglobin to relatively normal values. On admission, a huge tumor of the left kidney was palable. Roentgenograms of the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197506)35:6<1701::aid-cncr282035
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Traditional single-marker and multimarker molecular profiling approaches in bladder cancer do not account for major risk factors and their influence on clinical outcome. This study examined the prognostic value of molecular alterations across all disease stages after accounting for clinicopathological factor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27763
更新日期:2013-02-15 00:00:00
abstract:BACKGROUND:Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have a dismal prognosis and increased mortality. The few studies that have focused on the evaluation of prognostic factors in patients with LC have resulted in contradictory results. Thus, the tr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24041
更新日期:2009-01-15 00:00:00
abstract::Chromosome abnormalities from 17 malignancies that were studied using direct preparations and G-, Q-, and C-banding methods are presented and the findings assessed. The material used was from 6 primary cervical carcinomas, 5 primary and metastatic ovarian carcinomas and 6 other metastatic carcinomas. In general, chrom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2108::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) has immunomodulatory effects, including stimulating the activity of cytotoxic T cells and natural killer cells, and inducing the generation of lymphokine-activated killer cells. The authors investigated whether IL-2 may improve the duration of complete remission (CR) and survival in acut...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract::Seventeen cases of malignant melanoma of soft parts (clear cell sarcoma) are reported. The patients ranged from 9 to 70 years of age, but 13 were between 10 and 40 years of age. There were eight male patients and nine female patients. The most common tumor location (seven patients) was the foot, followed by the area a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900115)65:2<367::aid-cncr28206
更新日期:1990-01-15 00:00:00
abstract::Testicular function was studied in 26 men with sarcoma who received adjuvant treatment with doxorubicin, cyclophosphamide, and high-dose methotrexate (with or without radiotherapy). Testicular size, sperm output, and serum FSH, LH and testosterone levels were assessed after treatment. Five of 17 men who received chemo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2368::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:This study assessed the impact of surgical, histopathologic and patient-related factors on the risks of local and distant recurrence and overall survival for patients with stages I through IIIA nonsmall cell lung carcinoma (NSCLC) undergoing definitive resection with or without adjuvant chemotherapy. METHOD...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24133
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The polyamine system is a promising target for anticancer therapy. Ideally, an antineoplastic compound affecting this system should inhibit both ornithine decarboxylase and the polyamine transporter, and toxicity should be mild. Agmatine, decarboxylated L-arginine, appears to be such a compound. METHODS:Ade...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20407
更新日期:2004-08-15 00:00:00
abstract::The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911215)68:12<2612::aid-cncr282
更新日期:1991-12-15 00:00:00
abstract::Since 1981, 20 patients with anaplastic giant cell carcinoma of the thyroid have been prospectively treated according to a combination regimen of chemotherapy and external beam radiation therapy. Two types of chemotherapy were used every 4 weeks, depending on the patient's age. For those younger than 65 years, a combi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910201)67:3<564::aid-cncr28206
更新日期:1991-02-01 00:00:00
abstract::Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.32078
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:Several pathologic staging systems for malignant pleural mesothelioma (MPM) have been published, but none of them provide optimal survival stratification or stage distribution among patients treated with surgery. Interpretation of prior studies that correlate pathologic factors with outcome has been confound...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24886
更新日期:2010-03-15 00:00:00
abstract::Activities of glucosephosphate isomerase, lactate dehydrogenase, and NADP-isocitrate dehydrogenase were significantly elevated in breast cancer specimens from patients who responded favorably to combination cytotoxic chemotherapy regimens compared with those in carcinomas from patients failing to respond to the same c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<695::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract::The histopathology of 43 cases of carcinoma in the extrahepatic bile ducts was reported. All four cases of noninfiltrating carcinoma were papillary or polypoid in gross shape. Only one of the eight cases of papillary or polypoid cancers penetrated beyond the fibromuscular layer of the bile ducts, while most cases of n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840701)54:1<65::aid-cncr282054
更新日期:1984-07-01 00:00:00
abstract::A comprehensive immunologic and serologic analysis was performed on 31 untreated patients with Hodgkin's disease. Immune evaluations stressed T-cell functional activity and included traditional parameters (PHA responsiveness and delayed hypersensitivity skin reactivity), as well as newer functional assays (T-cell colo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810815)48:4<964::aid-cncr28204
更新日期:1981-08-15 00:00:00
abstract::The efficacy of trioxifene mesylate, a new antiestrogen, in the management of advanced breast cancer was evaluated in 69 patients. Fifty-two patients were randomly allocated to dose schedules of 5 mg, 10 mg, and 20 mg orally twice daily. There were five complete responders (10%), 22 partial responders (42%), and 9 pat...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19860101)57:1<40::aid-cncr282057
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Failure to detect metastasis to para-aortic nodes in patients with locally advanced cervical cancer leads to suboptimal treatment. No previous studies have prospectively compared positron emission tomography (PET)/computed tomography (CT) with laparoscopic extraperitoneal staging in the evaluation of para-ao...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.25739
更新日期:2011-05-01 00:00:00
abstract::Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811201)48:11<2371::aid-cncr282
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00