Abstract:
BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC). METHODS:A hospital-based case-control study, including 201 GC cases and 196 unaffected controls, was performed. DNA from peripheral blood samples was examined by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses were used to compute odds ratio (OR) and 95% confidence interval (CI) after adjusted for Helicobacter pylori infection, smoking, and other relevant factors. RESULTS:In 196 healthy Taiwanese, the distribution of genotype C/C was 42.3%, C/A was 48.0%, and A/A was 9.7%. The frequency of variant A/A genotype in GC case (4 of 201, 2%) was significantly lower than that of controls (19 of 196, 9.7%) (P < 0.005), conferring a 5-fold decrease in the risk of GC (OR, 0.20; 95% CI, 0.06-0.56) compared with the C/C genotype. Stratification of the GC cases according to their location (cardia and noncardia), histology (intestinal and diffuse), tumor stage (early and advanced), and lymph node metastasis (positive and negative) failed to reveal any heterogeneity with respect to E-cadherin genotype. CONCLUSIONS:The authors' data suggest that individuals with E-cadherin -160 A/A genotype have a decreased risk of GC. Further work is mandatory to clarify the functional relevance of the A allele in vivo and to confirm the inverse association of the A/A genotype with GC in large epidemiologic studies.
journal_name
Cancerjournal_title
Cancerauthors
Wu MS,Huang SP,Chang YT,Lin MT,Shun CT,Chang MC,Wang HP,Chen CJ,Lin JTdoi
10.1002/cncr.10371subject
Has Abstractpub_date
2002-03-01 00:00:00pages
1443-8issue
5eissn
0008-543Xissn
1097-0142pii
10.1002/cncr.10371journal_volume
94pub_type
杂志文章相关文献
CANCER文献大全abstract::Malignant schwannomas with rhabdomyoblastic differentiation have been termed malignant "Triton" tumors (MTT). To define the natural history of MTT, we have analyzed our experience (9 cases, the largest series reported) in combination with the 27 previously described in the literature (total 36 cases). This study was i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850601)55:11<2543::aid-cncr282
更新日期:1985-06-01 00:00:00
abstract::Prostate cancer is the most common male malignancy and the second or third leading cause of cancer death among men in the West. The descriptive epidemiology of prostate cancer suggests that it is a preventable disease. Prevention has the theoretical advantage of not only saving lives, but also reduce the morbidity of ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23009
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19960215)77:4<683::aid-cnc
更新日期:1996-02-15 00:00:00
abstract::Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197903)43:3<1089::aid-cncr282043
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to determine whether a very low presenting prostate-specific antigen (PSA) level was associated with greater prostate cancer-specific mortality (PCSM) among men with a Gleason score (GS) of 8 to 10. METHODS:The Surveillance, Epidemiology, and End Results program was used to i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29691
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In the current study, the authors propose the quantitative Gleason score (qGS), a modification of the current Gleason grading system for prostate cancer, based on the weighted average of Gleason patterns present in the pathology specimen. They hypothesize that the qGS can improve prostate cancer risk stratif...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27670
更新日期:2012-12-15 00:00:00
abstract:BACKGROUND:Patients with American Joint Committee on Cancer Stage IV advanced pancreatic carcinoma have been treated by systemic chemotherapy, intraarterial chemotherapy, radiation therapy, and multidisciplinary treatment using a combination of these. However, the outcome has not always been satisfactory. In the curren...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:Although acquired somatic mutations presumably are crucial in carcinogenesis, nothing is known about the chromosome aberrations of bilateral breast carcinomas. METHODS:Eighteen specimens from 16 bilateral carcinomas were analyzed cytogenetically. The banding analysis was supplemented with fluorescence in si...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950715)76:2<250::aid-cncr28207
更新日期:1995-07-15 00:00:00
abstract::The worldwide increase in cancer mortality demands a practical and effective chemopreventive approach to this problem. Using animal bioassay, the authors demonstrated protocatechuic acid (PCA, 3,4-dihydroxybenzoic acid), a simple and antioxidative phenolic acid present in fruits, vegetables, and nuts, to be an efficac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950315)75:6+<1433::aid-cncr282
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23391
更新日期:2008-05-15 00:00:00
abstract:BACKGROUND:An increased understanding of the biology of prostate carcinoma has led to the clinical evaluation of mechanism-based and targeted therapies. Modulating the immune system has been pursued through the use of both active and passive immunity as well as the ex vivo genetic manipulation of effector cells. A vari...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000915)89:6<1329::aid-cncr19>3
更新日期:2000-09-15 00:00:00
abstract:BACKGROUND:The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23787
更新日期:2008-10-01 00:00:00
abstract::An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831015)52:8<1470::aid-cncr2820
更新日期:1983-10-15 00:00:00
abstract:BACKGROUND:The presence of tumor at the inked margins (IMs) of breast specimens is associated with an increased risk of local recurrence after breast-conserving therapy for invasive breast carcinoma and ductal carcinoma in situ (DCIS). Given the importance of margin status, some have advocated the use of shaved margins...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) have activity in solid tumors. The authors evaluated an oral EGFR TKI, erlotinib, in patients with previously treated esophageal cancer. METHODS:Thirty patients with measurable, metastatic cancer of the esophageal and gastroeso...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25602
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207
更新日期:1995-09-15 00:00:00
abstract::Fever, clinical infection, bacteriologically documented infection, and death from infection were evaluated in 95 consecutive uninfected patients with severe granulocytopenia (less than 0.5 x 10(6)/liter). Patients were randomly allocated to reverse isolation and prophylactic oral nonabsorbable antibiotics or to open w...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810715)48:2<419::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract::A case-control study was conducted to assess the risk factors associated with the development of a contralateral primary breast cancer among women who had had a first primary breast cancer. Hospital records were reviewed for 292 women with an incident contralateral breast cancer, diagnosed in one of eight hospitals be...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880715)62:2<412::aid-cncr28206
更新日期:1988-07-15 00:00:00
abstract::Six hundred fifty-eight cases of previously untreated non-Hodgkin's lymphoma seen between 1970 and 1979 at the Medical Department, the Finsen Institute, were the basis for a comparative study of the prognostic value of the Rappaport, Kiel, and Lukes & Collins classifications and the new translation system, the Working...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850515)55:10<2442::aid-cncr282
更新日期:1985-05-15 00:00:00
abstract::From April 1985 through March 1988, 24 lung cancer patients with carcinomatous pleuritis were treated with a new combined treatment modality consisting of pulmonary resection and postoperative intrathoracic chemo-thermotherapy (PICT). They consisted of 15 male patients and nine female patients. A majority of the patie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891001)64:7<1422::aid-cncr2820
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti-neuroectodermal antibodies in the absence of PND. Whether...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21088
更新日期:2005-06-15 00:00:00
abstract::Glutamine may be an essential dietary component, especially for the support of intestinal mucosal growth and function. This study evaluated the effects of a glutamine-enriched elemental diet, administered before whole-abdominal radiation on gut glutamine metabolism, mucosal morphometrics, and bacterial translocation. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900701)66:1<62::aid-cncr282066
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-08-25 00:00:00
abstract:BACKGROUND:A proposed pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen (PSA) era. The impact of margin status on the survival outcome of patients with otherwise organ-confined disease (i.e., without extraprostatic extension o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980301)82:5<902::aid-cnc
更新日期:1998-03-01 00:00:00
abstract::This article describes the clinicopathologic features of six cases of uterine papillary serous carcinoma (UPSC), which developed several years after radiation therapy (RT) for cervical carcinoma. The possible etiologic role of radiation is discussed, and the literature on endometrial carcinomas developing after RT is ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<496::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3+<1139::aid-cncr282
更新日期:1994-08-01 00:00:00
abstract::Five patients with hepatocellular carcinoma in the caudate lobe were evaluated. Computed tomography (CT) scan and/or angiography clearly demonstrated multiple intrahepatic metastases in four (80%), and tumor thrombi in the portal vein in two (40%), and in the inferior vena cava in one. Even though there was no recogni...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861001)58:7<1557::aid-cncr2820
更新日期:1986-10-01 00:00:00
abstract::One hundred twenty-three women younger than 70 years of age and at clinical Stages I or II were enrolled in a randomized clinical trial of radical versus extended radical mastectomy. The 5-year survival rates in the radical and extended radical groups were 75 +/- 6.7% and 80 +/- 6.7%, respectively. (Cox P value for co...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19850215)55:4<880::aid-cncr28205
更新日期:1985-02-15 00:00:00
abstract::The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<370::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract:BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960215)77:4<607::AID-CNC
更新日期:1996-02-15 00:00:00