Abstract:
BACKGROUND:The current study was conducted to investigate the diagnostic value of neurologic evaluation for the prediction of intracranial metastases in cancer patients with new or changed headache. METHODS:Between February 1997 and February 2000, general practitioners and specialists referred cancer patients with new or changed headache to the Department of Neurology at the study institution. All patients underwent a structured history and neurologic examination. Magnetic resonance imaging (MRI) of the brain was used as the gold standard for determining the presence of intracranial metastases. The association between baseline patient characteristics, history variables, and variables from the neurologic examination in patients with intracranial metastases was evaluated by univariate and multivariate logistic regression analyses in combination with receiver operating characteristic (ROC) curve analyses. RESULTS:Sixty-eight consecutive patients were included in the current study (48 females and 20 males). The mean age of the patients was 57 years (range, 24-88 years; standard deviation +/- 13.3 years). Breast carcinoma was the primary tumor in 32 patients (47.1%) and lung carcinoma was the primary tumor in 12 patients (17.6%). Intracranial metastases occurred in 22 patients (32.4%). The occurrence of intracranial metastases was predicted in the multivariate logistic regression analyses by one baseline patient characteristic variable and 2 history variables (i.e., headache duration of < or =10 weeks [odds ratio (OR) of 11.0; 95% confidence interval (95% CI), 1.1-108.2], emesis [OR of 4.0; 95% CI, 1.1-14.3], and pain not of tension- type [OR of 6.7; 95% CI, 1.8-25.1]). No variable from the neurologic examination was found to add information to the prediction model. When at least one of the three predictors was present, all patients with intracranial metastases could be identified with this prediction model. MRI could be omitted in 12 patients (26%) without intracranial metastases. The ROC area under curve of this model was 0.83. CONCLUSIONS:Intracranial metastases were found in 32.4% of the cancer patients with headache as the presenting symptom. Although 3 significant clinical predictors were found (headache duration < or =10 weeks, emesis, and pain not of tension- type), few patients could be excluded from undergoing MRI because of a low specificity. Therefore, MRI of the brain was considered to be warranted in all patients in the current study.
journal_name
Cancerjournal_title
Cancerauthors
Christiaans MH,Kelder JC,Arnoldus EP,Tijssen CCdoi
10.1002/cncr.10379subject
Has Abstractpub_date
2002-04-01 00:00:00pages
2063-8issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/cncr.10379journal_volume
94pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1334::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract::Available information suggests that individuals with breast cancer gain weight during adjuvant treatment and that this weight gain may be associated with poor prognosis. Exploration of the factors which affect weight gain may aid in developing weight control interventions for these patients. To determine the factors w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910401)67:7<1954::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Febrile neutropenia (FN) is a serious and potentially life-threatening condition that may develop in patients with cancer who receive myelosuppressive chemotherapy. The risk of mortality from FN is not well characterized in current clinical practice. METHODS:Patients with cancer who were receiving chemother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25332
更新日期:2010-12-01 00:00:00
abstract::Malignant salivary gland neoplasms in children are rare. Such tumors usually occur in the parotid gland of older children. Sixteen cases of major salivary gland malignancy are reviewed, 14 occurring in the parotid gland and two in the submandibular gland. Adenoid cystic carcinoma was the most common malignancy encount...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1730::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<84::aid-cncr282049
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc
更新日期:1997-12-25 00:00:00
abstract::Twenty-three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on th...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910815)68:4<916::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract:BACKGROUND:The histogenesis of carcinosarcoma is still unknown. METHODS:A new human uterine cell line, EMTOKA, derived from a carcinosarcoma of the uterus, has been passed successfully in cell culture for more than 2 years. The cell line was established on April 11, 1989, in a uterine tumor of a 64-year-old Japanese w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930201)71:3<775::aid-cncr28207
更新日期:1993-02-01 00:00:00
abstract::Actuarial progression-free survival rate at 5 years of a series of 34 patients with medulloblastoma treated by combined surgery, radiotherapy, and chemotherapy was 71%. No relapses were observed in 14 patients followed for more than 5 years. Treatment consisted of a short postoperative course of vincristine (VCR) and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1956::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-08-25 00:00:00
abstract:BACKGROUND:The diagnosis of low-grade squamous intraepithelial lesion (LSIL), cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) was not included in the 2001 Bethesda System. It is used in some institutions to diagnose cases that fulfill criteria for both the diagnosis of LSIL and atypical squamous cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20004
更新日期:2009-04-25 00:00:00
abstract::Diagnostic advances currently have exceeded therapeutic gain. The present, however, is a transition phase. Chemotherapy, for example, has become curative for some tumors in recent years, rather than merely palliative, due to the precision permitted by advances in molecular biology. At this time, acceleration in the ba...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901015)60:8+<1931::aid-cncr282
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:This study was performed to evaluate the effect of positive margins, Gleason grade, and capsular penetration on progression after radical prostatectomy. METHODS:The authors followed 507 men with totally embedded retropubic prostatectomy specimens performed for clinical Stages A and B prostate cancer for a m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3582::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract::Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2353::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract::The care of patients with cancer and chronic pain, often complicated and demanding, strains the resources of a single physician. Continuity of care programs, such as that developed by the Pain Service of Memorial Sloan-Kettering Cancer Center (New York), with good communication and liaison work between hospital and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2289::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23216
更新日期:2008-02-01 00:00:00
abstract::Lymphoid cells from two patients with hand-mirror variant of acute lymphoblastic leukemia (ALL) were studied with various monoclonal antibodies in attempts to determine their derivation and differentiation. The predominant feature of the malignant bone marrow cells was strong reactivity with antibody 3A1, which stains...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850101)55:1<77::aid-cncr282055
更新日期:1985-01-01 00:00:00
abstract::POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920601)69:11<2697::aid-cncr282
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:A study was undertaken to identify new immunogenic human leukocyte antigen (HLA)-A 2402-restricted epitopes from human papillomavirus (HPV) type 16 E7 protein for immunotherapy against cervical cancer. METHODS:Synthetic overlapping peptides were screened by measuring the frequency of CD8(+) cytotoxic T lymp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26468
更新日期:2012-04-15 00:00:00
abstract::One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<84::aid-cncr282065
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:It has been suggested that tissue factor (TF) plays an important role in tumor metastasis. Its expression in sarcoma cells was reported to up-regulate the vascular endothelial growth factor (VEGF) gene and thereby enhance tumor angiogenesis, which is essential to tumor metastasis. Although many malignant tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000115)88:2<295::aid-cnc
更新日期:2000-01-15 00:00:00
abstract::Solitary extramedullary plasmacytomas are rare tumors, reported to occur most commonly in the upper respiratory passages, but which also are rarely seen in the middle and lower gastrointestinal system. This report documents the first primary plasmacytoma of the esophagus. A 67-year-old Caucasian man complained of dysp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<943::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify biologic differences between ovarian clear cell carcinoma and other ovarian adenocarcinomas by comparing the expression of cell cycle regulatory molecules and by analyzing the survival of the patients. METHODS:In 51 cases of epithelial ovarian carcinoma, the express...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990201)85:3<669::aid-cnc
更新日期:1999-02-01 00:00:00
abstract::Turcot's syndrome is a rare, genetically transmittable disease in which patients with colonic polyposis (possibly complicated by the progression to adenocarcinoma) have malignant central nervous system neoplasms. Dominant, recessive, and sporadic cases have been described. A 26-year-old man is reported with no relevan...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911001)68:7<1633::aid-cncr2820
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow-up has tended to be short. Furthermore, the different therapeutic strategies used in these patients has made it difficult to assess survival rates and prognostic factors. METHODS:In 1989...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23003
更新日期:2007-11-01 00:00:00
abstract::Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8+<1887::aid-cncr282
更新日期:1986-10-15 00:00:00
abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820
更新日期:1988-10-15 00:00:00
abstract:METHODS:The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR). RESULTS:Nonpalpable prostate cancer was detected by TRUS alone in 18% (29 of 161) and by TUR...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1+<211::aid-cncr2820
更新日期:1992-07-01 00:00:00
abstract::The experience of 260 patients with endometrial carcinoma was reviewed. The influence of factors such as age, stage of disease, grade and degree of myometrial penetration on the survival was presented, showing that survival decreases in elderly patients, in patients with advanced stage of disease, when the tumor is un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197702)39:2<675::aid-cncr2820390
更新日期:1977-02-01 00:00:00