Abstract:
:Twenty-three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on the incidence of the second tumor. In 21 patients (four synchronous and 17 sequential tumors), histocompatibility antigens (HLA) were determined; HLA-B14 was increased significantly in the sequential tumor group. Tendencies toward an increase of HLA-DR5 and HLA-DR7 also were found. The HLA-DR1, HLA-DR3, and HLA-DR4 showed a tendency toward a decreased frequency. Therefore genetic factors might be important in the development of sequential bilateral testicular cancers.
journal_name
Cancerjournal_title
Cancerauthors
Kratzik C,Aiginger P,Kuber W,Riccabona M,Kührer I,Joos H,Frick J,Amann G,Mayr Wdoi
10.1002/1097-0142(19910815)68:4<916::aid-cncr28206subject
Has Abstractpub_date
1991-08-15 00:00:00pages
916-21issue
4eissn
0008-543Xissn
1097-0142journal_volume
68pub_type
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