Risk factors for bilateral testicular germ cell tumors. Does heredity play a role?

Abstract:

:Twenty-three bilateral testicular germ cell tumors (four synchronous and 19 sequential tumors) were investigated for potential risk factors. The incidence of maldescensus testis was not found to be higher than in patients with unilateral disease. The histologic findings of the first tumor did not have any effect on the incidence of the second tumor. In 21 patients (four synchronous and 17 sequential tumors), histocompatibility antigens (HLA) were determined; HLA-B14 was increased significantly in the sequential tumor group. Tendencies toward an increase of HLA-DR5 and HLA-DR7 also were found. The HLA-DR1, HLA-DR3, and HLA-DR4 showed a tendency toward a decreased frequency. Therefore genetic factors might be important in the development of sequential bilateral testicular cancers.

journal_name

Cancer

journal_title

Cancer

authors

Kratzik C,Aiginger P,Kuber W,Riccabona M,Kührer I,Joos H,Frick J,Amann G,Mayr W

doi

10.1002/1097-0142(19910815)68:4<916::aid-cncr28206

subject

Has Abstract

pub_date

1991-08-15 00:00:00

pages

916-21

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

68

pub_type

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