Castleman's disease in POEMS syndrome with elevated interleukin-6.

Abstract:

:POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lymph node hyperplasia). Cerebrospinal fluid (CSF) and serum interleukin-6 (IL-6) levels were abnormally elevated at various times during a 9-month period. The authors conclude that the plasma cell dyscrasia associated with the POEMS syndrome of this patient was Castleman's disease. Elevation of serum IL-6 levels might contribute to the pathogenesis of the POEMS syndrome.

journal_name

Cancer

journal_title

Cancer

authors

Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

doi

10.1002/1097-0142(19920601)69:11<2697::aid-cncr282

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

2697-703

issue

11

eissn

0008-543X

issn

1097-0142

journal_volume

69

pub_type

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