Abstract:
BACKGROUND:Tamoxifen and aminoglutethimide are two hormone therapies reported to be effective palliative approaches for patients with metastatic breast cancer. The current trial was designed to evaluate their relative therapeutic effectiveness. METHODS:Two hundred forty-nine postmenopausal women with advanced breast cancer were randomized in an Eastern Cooperative Oncology Group (ECOG) Phase III study to treatment with adrenalectomy, aminoglutethimide, or tamoxifen with crossover to alternate therapy if disease progressed. Adrenalectomy was dropped as a treatment after 2 years because of low patient accrual. RESULTS:There were 216 evaluable patients entered in the study with 108 initially randomized to aminoglutethimide and 108 to receive tamoxifen therapy. The overall response rate for aminoglutethimide was 45%, and for tamoxifen it was 27%. One institution had a response rate of 60% with aminoglutethimide and only 4% with tamoxifen, whereas all of the other institutions combined had a response rate of 41% with aminoglutethimide and 34% with tamoxifen. Eighty-seven evaluable patients crossed over to the other drug (44 to aminoglutethimide and 43 to tamoxifen). There was a 36% response rate to aminoglutethimide and 19% to tamoxifen, with stable disease in 36% of both groups. The overall survival rates were identical. Toxicity was greater with aminoglutethimide (dermatitis) but was not life-threatening. Glucocorticoid support with either dexamethasone or hydrocortisone was acceptable. CONCLUSIONS:Both aminoglutethimide and tamoxifen produced responses in postmenopausal patients with breast cancer, and a significant number of crossover responses were observed. Of interest in this randomized study was the observation that one institution had a markedly different response rate on induction, reinforcing the need for multi-institution trials in Phase III studies.
journal_name
Cancerjournal_title
Cancerauthors
Gale KE,Andersen JW,Tormey DC,Mansour EG,Davis TE,Horton J,Wolter JM,Smith TJ,Cummings FJdoi
10.1002/1097-0142(19940115)73:2<354::aid-cncr28207subject
Has Abstractpub_date
1994-01-15 00:00:00pages
354-61issue
2eissn
0008-543Xissn
1097-0142journal_volume
73pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CANCER文献大全abstract:BACKGROUND:Medical records of 50 patients with malignant mesothelioma were reviewed to determine the clinical features and factors influencing survival. METHODS:Charts of all patients whose conditions were diagnosed as malignant mesothelioma were abstracted and analyzed by statistical software. RESULTS:The male-to-fe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921215)70:12<2969::aid-cncr282
更新日期:1992-12-15 00:00:00
abstract:BACKGROUND:Some studies have suggested that women with metastatic malignant melanoma have a better survival rate than men. However, little is known about the effect of gender on survival in combination with other clinical variables and treatment variables. Thus, an analysis of 813 eligible patients from 15 consecutive ...
journal_title:Cancer
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1002/1097-0142(20010315)91:6<1148::aid-cncr1111
更新日期:2001-03-15 00:00:00
abstract::One-hundred and fifty-one adults with acute non-lymphocytic leukemia (ANLL) were entered into an Eastern Cooperative Oncology Group protocol (EST-1473) comparing twice daily cytosine arabinoside and thioguanine (AT) with weekly cyclophosphamide, cytosine arabinoside, and methotrexate (CAM) for remission induction. Of ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800115)45:2<224::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::The serial technetium 99 (99Tc) bone scans of 76 patients with Stage D-2 prostate cancers were reviewed. Sites of metastases in skeletal areas in decreasing order were vertebrae, ribs, pelvis, long bones, and skull. Patients with one or two involved skeletal areas had a significantly longer progression-free interval a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910715)68:2<316::aid-cncr28206
更新日期:1991-07-15 00:00:00
abstract:BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20782
更新日期:2005-01-01 00:00:00
abstract::On account of the functioning bigonads, true hermaphrodites show a wide range of morphological anomalies. The patient under discussion had an ovary on one side and an ovotestis on the other side; both of them functioned to some extent to produce a rudimentary uterus, fallopian tubes and a few Woolfian remnants. The ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2726::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract::Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881015)62:1+<1823::aid-cncr282
更新日期:1988-10-15 00:00:00
abstract:BACKGROUND:Recently, peripheral lung adenocarcinomas (PLA) measuring < or = 3 cm in greatest dimension often have been diagnosed using diagnostic radiology. The objective of the current study was to determine which cytologic factors are associated with a favorable outcome and an unfavorable outcome in patients with PLA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20686
更新日期:2005-02-25 00:00:00
abstract:BACKGROUND:The incidence of rectal cancer in the United States in young patients is considered to be low. Underestimating this incidence may result in a failure to diagnose younger patients with rectal cancer in a timely manner. METHODS:The authors conducted a retrospective cohort study using Surveillance, Epidemiolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25432
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:Estrogen receptor-alpha (ERalpha) is variably expressed in hepatocellular carcinoma (HCC) and is believed to be correlated with prognosis and survival. Recently, another estrogen receptor (ERbeta) has been identified, but its relevance in liver diseases is unknown. METHODS:The expression of ERbeta in the li...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11528
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Single-agent chemotherapy produces partial responses in the range of 7-27% in patients with Stage IV nonsmall cell lung carcinoma (NSCLC). Cisplatin-based combination regimens have achieved higher response rates but with significant toxicity. Two prior studies employing 24-hour infusions of paclitaxel showed...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:Previous studies have shown that low levels of p27(Kip1), an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquitin-mediated degradation. I...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010501)91:9<1745::aid-cncr1193
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Epstein-Barr virus (EBV) infection has been implicated in the pathogenesis of certain subtypes of salivary gland tumors in the adult population. However, to the authors' knowledge its role in pediatric salivary gland tumors, a rare disease, has not been explored previously. METHODS:Thirteen cases of primary...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20000715)89:2<463::aid-cncr35>3.
更新日期:2000-07-15 00:00:00
abstract::A pilot study was done to determine the feasibility of adjuvant photodynamic therapy (PDT) in recurrent retroperitoneal sarcomas. Ten patients, who had recurrences after conventional methods of treatment, had repeated resections of the tumor and intraoperative photodynamic treatment to the tumor bed. The methods and e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880315)61:6<1248::aid-cncr2820
更新日期:1988-03-15 00:00:00
abstract::Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<2040::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract::Effective management of hepatic metastases from ocular and cutaneous melanoma remains a major therapeutic challenge. Treatment options include hepatic resection, hepatic intra-arterial (HIA) chemotherapy, chemoembolization, and hepatic perfusions. Evaluating the efficacy of these interventions is limited by the retros...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28480
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS:The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:The mode of tumor growth of intrahepatic cholangiocarcinoma (CC) varies considerably from patient to patient. This study describes the clinicopathologic variety of the extraductal mass-forming type of CC. METHODS:Patients with CC characterized by an extraductal mass (n = 26) who underwent hepatectomy from 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951215)76:12<2449::aid-cncr282
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:The authors evaluated the role of 5-aminolevulinic acid (5-ALA)-induced fluorescence endoscopy (AFE) in the detection of flat urothelial lesions in light of the suggestions made for flat neoplastic lesions within the 1999 World Health Organization (WHO) classification of urinary bladder tumors. METHODS:From...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10821
更新日期:2002-09-15 00:00:00
abstract::Epithelioid sarcoma is an uncommon tumor characterized by its appearance in the distal extremities (especially the forearm, wrist, and ankle), the tendency to recur locally, and high probability of spread to regional lymph nodes. Most patients have been treated surgically, and the potential role of radiation therapy a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<1022::aid-cncr2820
更新日期:1983-09-15 00:00:00
abstract::Clinicopathologic correlations were made in 50 patients with follicular large cell (FLC) lymphoma to better define the influence of a variety of clinical and pathologic features on survival and the potential for continuous freedom from disease. The 5- and 10-year actuarial survivals for the entire group of patients ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870415)59:8<1470::aid-cncr2820
更新日期:1987-04-15 00:00:00
abstract::A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1331::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a uni...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33078
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data for the years 1973-1992 documented that patients age < 50 years presented with more advanced disease. Because of the increase in the incidence rate of lung adenocarcinoma in the past few decades and the presentation of more advanced disease in young pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000415)88:8<1837::aid-cn
更新日期:2000-04-15 00:00:00
abstract:BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1097-0142(19960201)77:3<441::AID-CNC
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending therapy was associated with their EOL care. METHODS:Coping with Cancer is a multisite, prospect...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25217
更新日期:2010-10-01 00:00:00
abstract::Flow cytometric measurements were done on 51 ovarian carcinoma specimens collected from consecutive patients in a prospective study. The ploidy status was related to the course of the disease. The tumors from 26 (52%) of 50 evaluable patients had DNA aneuploidy. Patients with diploid tumors were more often considered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<971::aid-cncr28206
更新日期:1988-03-01 00:00:00
abstract::Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed between thymidylate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890315)63:6+<1008::aid-cncr282
更新日期:1989-03-15 00:00:00
abstract::Nine years after biopsy and radiation therapy for an extramedullary plasmacytoma of the nasal cavity, a 64-year-old man developed locally recurrent tumor. Repeat biopsy revealed tumor identical in hematoxylin and eosin stain (H & E) appearance to that found originally, leading to the diagnosis of recurrent extramedull...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870701)60:1<88::aid-cncr282060
更新日期:1987-07-01 00:00:00
abstract::Breast cancer is one of the most responsive of the common solid tumors when systemic therapy is indicated in the treatment of locally advanced or disseminated cancer. Many single agents have been useful in inducing remission in mammary carcinoma, but in recent years various drug combinations have been developed that a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4+<1079::aid-cncr282
更新日期:1980-08-15 00:00:00