Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma.

Abstract:

:A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci of calcitonin-producing C-cells were demonstrable by immunocytochemical technique and were closely associated with areas of amyloid stroma of the tumor. Efforts at localization of insulin and gastrin within the tumor cells gave negative results. While the results in the present case offer additional support for an APUD cell origin of strumal carcinoids, the presence of the calcitonin-producing C-cells within the tumor raises interesting histogenetic possibilities as to whether these lesions are derived from C-cells or represent an ovarian carcinoid with foci of C-cell differentiation.

journal_name

Cancer

journal_title

Cancer

authors

Dayal Y,Tashjian AH Jr,Wolfe HJ

doi

10.1002/1097-0142(197904)43:4<1331::aid-cncr282043

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

1331-8

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

43

pub_type

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