Management of locally advanced and disseminated breast cancer--chemotherapy.

abstract：:The National Cancer Institute (NCI) has increased its emphasis in cancer prevention by undertaking a number of human intervention trials. Special emphasis is placed on chemoprevention, diet, and smoking and tobacco use. Some 24 clinical trials are ongoing in chemoprevention to assess the role of specific chemicals (na...

journal_title：Cancer

authors： Cullen JW

更新日期：1988-10-15 00:00:00

abstract：BACKGROUND:Ovarian tumors of borderline malignancy have a less aggressive behavior and tend to occur at a younger age than their invasive counterparts. The role and extent of fertility-sparing conservative treatments is under continuous evaluation. METHODS:The current study was a retrospective review of 82 patients wi...

journal_title：Cancer

authors： Gotlieb WH,Flikker S,Davidson B,Korach Y,Kopolovic J,Ben-Baruch G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Notwithstanding some controversy regarding the benefits of screening mammography, it is generally assumed that the effects are the same for women of all race/ethnic groups. Yet evidence for its efficacy from clinical trial studies comes primarily from the study of white women. It is likely that mammography i...

journal_title：Cancer

authors： Jones BA,Patterson EA,Calvocoressi L

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...

journal_title：Cancer

authors： Rausch SM,Clark MM,Patten C,Liu H,Felten S,Li Y,Sloan J,Yang P

更新日期：2010-09-01 00:00:00

abstract：:Clinical trials are becoming increasingly difficult to carry out in the face of a changing health care delivery system. The reluctance of third party payers to reimburse for experimental therapy and the growing practice of providers to limit resources allocated for the care of cancer patients undergoing such therapies...

journal_title：Cancer

authors： Engelking C

更新日期：1991-03-15 00:00:00

abstract：:Thrombocytopenia in patients with multiple myeloma is usually due to chemotherapy or marrow replacement with myeloma cells. Two patients with multiple myeloma who fulfilled criteria for the diagnosis of immune thrombocytopenic purpura are presented. The etiologic and therapeutic implications of this unusual associatio...

journal_title：Cancer

authors： Verdirame JD,Feagler JR,Commers JR

更新日期：1985-09-01 00:00:00

abstract：:Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate ...

journal_title：Cancer

authors： Creagan ET,Ingle JN,Ahmann DL,Green SJ

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Patients who present with squamous cell carcinoma metastatic to cervical lymph nodes and no clinically apparent primary site present a therapeutic dilemma. Positron emission tomography imaging with 2-[F-18]fluoro-2-deoxy-D-glucose (FDG-PET) has been shown to be useful for the examination of known primary tum...

journal_title：Cancer

authors： Greven KM,Keyes JW Jr,Williams DW 3rd,McGuirt WF,Joyce WT 3rd

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown an antiproliferative effect of tumor necrosis factor (TNF) against various nonsmall cell lung carcinoma (NSCLC) cell lines. However, clinical trials of combined interleukin-2 and TNF-alpha in patients with advanced NSCLC have demonstrated both conflicting and disappointing results...

journal_title：Cancer

authors： Tran TA,Kallakury BV,Ambros RA,Ross JS

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the source of advanced cancer patients' information about their prognosis and determine whether this source of information could explain racial disparities in the accuracy of patients' life expectancy estimates (LEEs). METHODS:Coping With Cancer was a prospective, ...

journal_title：Cancer

authors： Trevino KM,Zhang B,Shen MJ,Prigerson HG

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Secondary acute myeloid leukemia (AML) after treatment with epipodophyllotoxins is being observed with increased frequency. Therapeutic options are limited for patients with secondary AML and the role of bone marrow transplantation is unclear. METHODS:The authors report the treatment outcome of a cohort of ...

journal_title：Cancer

authors： Sandler ES,Friedman DJ,Mustafa MM,Winick NJ,Bowman WP,Buchanan GR

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND AND METHODS:A univariate and multivariate analysis for the correlation between histomorphologic factors and prognosis was made using data from 1116 patients with soft tissue sarcoma, including 1005 cases available with complete histologic and follow-up data. RESULTS:The overall 5-year survival rate was 43.6...

journal_title：Cancer

authors： Hashimoto H,Daimaru Y,Takeshita S,Tsuneyoshi M,Enjoji M

更新日期：1992-12-15 00:00:00

abstract：:The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

journal_title：Cancer

authors： Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

更新日期：1990-02-15 00:00:00

abstract：:A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...

journal_title：Cancer

authors： Antman KH,Ruxer RL Jr,Aisner J,Vawter G

更新日期：1984-07-15 00:00:00

abstract：:Interleukin-2 (IL2) is essential for the expansion of antigen-triggered lymphocytes and cytotoxic T-cells, processes necessary for tumor control that are frequently depressed in malignancy. The authors measured certain aspects of IL2 function in cancer patients and controls and correlated the findings with the general...

journal_title：Cancer

authors： Wanebo HJ,Pace R,Hargett S,Katz D,Sando J

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Recent scientific advances provide the opportunity to identify women in the general population at increased breast cancer risk and to offer effective early detection and disease prevention interventions. METHODS:A pedigree assessment tool (PAT) was designed to identify women in primary care settings who are...

journal_title：Cancer

authors： Hoskins KF,Zwaagstra A,Ranz M

更新日期：2006-10-15 00:00:00

abstract：:An adequate operation for colorectal carcinoma involves removal of the primary tumor and wide excision of the mesentery with its contained regional lymph nodes and lymphovascular pathways. Enker and DeCosse state that radical resection, i.e., total mesenteric lymphadenectomy encompassing the origins of the complete ar...

journal_title：Cancer

authors： Leffall LD Jr

更新日期：1983-06-15 00:00:00

abstract：BACKGROUND:The management of children with hypothalamic (H) and/or chiasmatic (C) tumors remains controversial. We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/...

journal_title：Cancer

authors： Fouladi M,Wallace D,Langston JW,Mulhern R,Rose SR,Gajjar A,Sanford RA,Merchant TE,Jenkins JJ,Kun LE,Heideman RL

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Several studies have recently reported on the importance of quality of life (QOL) in predicting the survival of patients with lung carcinoma. To confirm these reports, the relationship between survival and QOL, as measured by the European Organization for Research and Treatment of Cancer (EORTC) Quality of L...

journal_title：Cancer

authors： Herndon JE 2nd,Fleishman S,Kornblith AB,Kosty M,Green MR,Holland J

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activity of cancer cells an...

journal_title：Cancer

authors： Suehiro T,Matsumata T,Itasaka H,Yamamoto K,Kawahara N,Sugimachi K

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...

journal_title：Cancer

authors： Pekar G,Hofmeyer S,Tabár L,Tarján M,Chen TH,Yen AM,Chiu SY,Hellberg D,Gere M,Tot T

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Despite its established benefits, palliative care (PC) is rarely utilized for hematopoietic stem cell transplant (HSCT) patients. We sought to examine transplant physicians' perceptions of PC. METHODS:We conducted a cross-sectional survey of transplant physicians recruited from the American-Society-for-Bloo...

journal_title：Cancer

authors： El-Jawahri A,LeBlanc TW,Burns LJ,Denzen E,Meyer C,Mau LW,Roeland EJ,Wood WA,Petersdorf E

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:In a previous study of gene array data, the authors identified survivin as a candidate marker of aggressiveness in clear cell renal cell carcinoma (ccRCC). What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer-specific sur...

journal_title：Cancer

authors： Parker AS,Kosari F,Lohse CM,Houston Thompson R,Kwon ED,Murphy L,Riehle DL,Blute ML,Leibovich BC,Vasmatzis G,Cheville JC

更新日期：2006-07-01 00:00:00

abstract：:A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...

journal_title：Cancer

authors： Morgan RT,Quinn LA,Moore GE,Semple TU,Woods LK

更新日期：1980-03-15 00:00:00

abstract：BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...

journal_title：Cancer

authors： Ganesh S,Sier CF,Heerding MM,van Krieken JH,Griffioen G,Welvaart K,van de Velde CJ,Verheijen JH,Lamers CB,Verspaget HW

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:: The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy. METHODS:: The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type...

journal_title：Cancer

authors： Alderman AK,Collins ED,Schott A,Hughes ME,Ottesen RA,Theriault RL,Wong YN,Weeks JC,Niland JC,Edge SB

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:There is little information on the function of dendritic cells in women with human papillomavirus (HPV)-related cervical squamous intraepithelial lesions (SILs). In the current study the functions of dendritic cells in the development of T-cell immunity in women with cervical SILs were assessed. METHODS:The...

journal_title：Cancer

authors： Lee BN,Follen M,Rodriquez G,Shen DY,Malpica A,Shearer WT,Reuben JM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...

journal_title：Cancer

authors： Frittitta L,Sciacca L,Catalfamo R,Ippolito A,Gangemi P,Pezzino V,Filetti S,Vigneri R

更新日期：1999-01-15 00:00:00

abstract：:The American Joint Committee on Cancer proposes the following criteria for evaluating putative prognostic factors: they must be (1) significant, (2) independent, and (3) clinically important. Furthermore, we suggest the criteria for selecting a prognostic system that includes TNM and new prognostic factors. These crit...

journal_title：Cancer

authors： Burke HB,Henson DE

更新日期：1993-11-15 00:00:00

abstract：:Aggregates of cells resembling those of cutaneous nevi have been found in the capsules of lymph nodes. Although seemingly rare, this extraordinary lesion could conceivably occur often enough to be more than a pathological curiosity, and should be differentiated from metastatic tumor. Slides from every axillary lymph n...

journal_title：Cancer

authors： Ridolfi RL,Rosen PP,Thaler H

更新日期：1977-01-01 00:00:00