Abstract:
BACKGROUND:Several studies have recently reported on the importance of quality of life (QOL) in predicting the survival of patients with lung carcinoma. To confirm these reports, the relationship between survival and QOL, as measured by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire and Duke-UNC Social Support Scale, was examined within a group of 206 patients with advanced nonsmall cell lung carcinoma treated in a randomized clinical trial conducted by the Cancer and Leukemia Group B (CALGB 8931). METHODS:Patients completed the EORTC instrument and the Duke-UNC Social Support Scale at baseline in the clinic. The Cox proportional hazards model was used to determine the incremental contribution QOL provided in predicting survival beyond the effect of known clinical prognostic variables. RESULTS:Clinical factors that were jointly predictive of poorer survival included low performance status, nonadenocarcinoma histology, presence of dyspnea, weight loss greater than 5%, albumin level less than 3.5 mg/dL, and adrenal metastases. Univariate analyses showed that patient-reported EORTC subscales describing increased pain, appetite loss, fatigue, lung carcinoma symptoms, poorer overall QOL, and poorer physical functioning predicted significantly poorer survival. Multivariate analyses showed that, after adjustment for clinical factors, overall QOL was not a significant predictor of survival. Rather, the only EORTC subscale of prognostic importance was the pain subscale, in which a 40-point increase was associated with a 27% increase in the hazard rate. CONCLUSIONS:This study did not confirm the prognostic importance of overall QOL. Rather, after adjustment for significant clinical factors, a patient-provided pain report had the greatest prognostic importance.
journal_name
Cancerjournal_title
Cancerauthors
Herndon JE 2nd,Fleishman S,Kornblith AB,Kosty M,Green MR,Holland Jdoi
10.1002/(sici)1097-0142(19990115)85:2<333::aid-cncsubject
Has Abstractpub_date
1999-01-15 00:00:00pages
333-40issue
2eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19990115)85:2<333::AID-CNCjournal_volume
85pub_type
临床试验,杂志文章,随机对照试验相关文献
CANCER文献大全abstract:BACKGROUND:Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors of the nervous system. Cutaneous melanoma and nervous system tumors may independently aggregate in families. There are, however, no previous reports of increased likelihood of tumors of the nervous sys...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951101)76:9<1571::aid-cncr2820
更新日期:1995-11-01 00:00:00
abstract::Forty-two cases of sarcomatoid renal cell carcinoma were reviewed clinicopathologically. Twenty-four patients were men, and 18 women; average age was 56.2 years (range, 30-81 years). Eight, 9, 13, and 12 cases were Stages I, II, III, and IV, respectively. Three morphologic patterns of sarcomatoid components were ident...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870201)59:3<516::aid-cncr28205
更新日期:1987-02-01 00:00:00
abstract::Four hundred forty-seven women attending a breast clinic because of either suspicious lesions, anxiety about breast cancer, follow-up after the removal of a benign breast lesion, or a family history of breast cancer had a routine test for percentage of ferritin-bearing lymphocytes ( FBL ) in their peripheral blood. Am...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840701)54:1<84::aid-cncr282054
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Radiotherapy (RT) after breast-conserving surgery (BCS) has produced significant reductions in ipsilateral breast carcinoma (BC) recurrence. It was shown previously that a delay in the initiation of RT resulted in a higher local recurrence (LR) rate. In the current retrospective analysis, the authors investi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21161
更新日期:2005-07-15 00:00:00
abstract:BACKGROUND:The authors' goal was to characterize hospice enrollment and aggressiveness of care for pancreatic cancer patients at the end of life. METHODS:Surveillance, Epidemiology, and End Results and linked Medicare claims data (1992-2006) were used to identify patients with pancreatic cancer who had died (n = 22,81...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26115
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The current study tested the hypothesis that the clinical outcome of patients with localized esophageal carcinoma after preoperative chemoradiotherapy (CTRT) depends on histology. METHODS:The authors stratified patients by adenocarcinoma (ACA) or squamous cell carcinoma (SCC) and compared the overall surviv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21601
更新日期:2006-02-01 00:00:00
abstract::High tissue concentrations of human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were revealed by radioimmunoassay in a hepatic tumor which was surgically removed from a two-year, eight-month-old boy manifesting sexual precocity. Histologically the tumor showed an embryonal type hepatoblastoma admixed with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830501)51:9<1647::aid-cncr2820
更新日期:1983-05-01 00:00:00
abstract::This communication reports four patients treated with the anthracycline adriamycin and irradiation either concurrently or sequentially, who demonstrated apparent augumentation of radiation reactions. Two of these patients demonstrated the so-called "recall" phenomenon. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<946::aid-cncr2820360
更新日期:1975-09-01 00:00:00
abstract::Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leuke...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197902)43:2<718::aid-cncr2820430
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Greater than one-half of children who are treated for acute lymphoblastic leukemia (ALL) develop ≥1 treatment-related medical conditions in their lifetime, many of which are known risk factors for diabetes mellitus. In the current study, the authors evaluated the prevalence and risk factors of diabetes melli...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32596
更新日期:2020-02-15 00:00:00
abstract::C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<827::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:Patients with familial adenomatous polyposis develop periampullary adenomas at a high rate. However, little is known regarding the factors that control the growth, the natural history, or the malignant potential of these tumors. METHODS:In this study, the authors systematically evaluated the expression of t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950715)76:2<187::aid-cncr28207
更新日期:1995-07-15 00:00:00
abstract:BACKGROUND:The objective of this study was to assess whether coregistered whole brain (WB) magnetic resonance imaging-positron emission tomography (MRI-PET) would increase the number of correctly upstaged patients compared with WB PET-computed tomography (PET-CT) plus dedicated brain MRI in patients with nonsmall cell ...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28000
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Ewing sarcoma family of tumors (ESFTs) are the second most common bone tumor, that most often affects persons ages 3-40 years. The ESFTs rely on signaling through the insulin-like growth factor-1 receptor (IGF-1R) for growth and transformation. The current studies were performed to determine the levels of IG...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011201)92:11<2941::aid-cncr100
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Specialty of the endoscopist has been related to the postcolonoscopy interval risk of colorectal cancer (CRC). However, the impact of such a difference on the long-term CRC prevention rate by screening colonoscopy is largely unknown. METHODS:A Markov model was constructed to simulate the efficacy and cost o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27664
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:: Histologic parameters of melanoma deposits in sentinel lymph nodes (SLNs) have been shown to be predictive of clinical outcome and the presence or absence of tumor in non-SLNs, but assessment of these parameters is prone to interobserver variation. METHODS:: Histologic sections of 44 SLNs containing metas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24298
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Questions have existed as to whether residential segregation is a mediator of racial/ethnic disparities in breast cancer care and breast cancer mortality, or has a differential effect by race/ethnicity. METHODS:Data from the Surveillance, Epidemiology, and End Results-Medicare database on white, black, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23828
更新日期:2008-10-15 00:00:00
abstract:BACKGROUND:The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention. METHODS:By using data f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31598
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date. METHODS:The authors analyzed all patients who had localized and/...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26357
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Plasma acidic glutathione S-transferase (GST-pi) concentrations in 135 patients with gastrointestinal cancer were measured by an improved radioimmunoassay (RIA). METHODS:Blood was collected into a silicified glass tube containing a specific anticoagulant. The plasma, which was separated rapidly by centrifug...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951015)76:8<1363::aid-cncr2820
更新日期:1995-10-15 00:00:00
abstract::A prospective study was carried out on 22 patients to assess the diagnostic ability to stage renal cell carcinoma by computed tomography, dynamic computed tomography, arteriography, ultrasonography, and radionuclide scanning. Dynamic computed tomography remedied the most consequential diagnostic shortcomings of conven...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841115)54:10<2205::aid-cncr282
更新日期:1984-11-15 00:00:00
abstract::The care of patients with cancer and chronic pain, often complicated and demanding, strains the resources of a single physician. Continuity of care programs, such as that developed by the Pain Service of Memorial Sloan-Kettering Cancer Center (New York), with good communication and liaison work between hospital and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2289::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract::Sixty-four adult patients with refractory acute lymphocytic leukemia (ALL) received salvage therapy with the vincristine, doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and dexamethasone (VAD) regimen consisting of induction chemotherapy with the three agents followed by multiple-agent maintenance therapy...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1<16::aid-cncr282064
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Metallothioneins (MT) are endogenous metalloproteins involved in the homeostasis of essential metals and detoxification of toxic metals. Some recent experimental studies suggested tumor resistance to cisdiamminedichloroplatin may be associated with overexpression of MT in the tumor. METHODS:The presence of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931115)72:10<3029::aid-cncr282
更新日期:1993-11-15 00:00:00
abstract::Intraoperative radiotherapy (IOR) or "direct view" irradiation permits the delivery of a single exposure of high-energy electrons to a surgically exposed tumor. Surgical exposure permits physical retraction of normal uninvolved tissues away from the IOR beam as well as the accurate assessment of the target volume. IOR...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:2+<2807::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract::To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1262::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract::One hundred and sixty-two cases of Stage IA microinvasive carcinoma of the cervix are presented. These patients represent the combined experience at the University of Miami School of Medicine, Miami, Florida, and Downstate Medical Center, Brooklyn, New York. The criteria used in both institutions are 1) penetration of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<414::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin. METHODS:In this study, the authors prospectively enrolled 25 patients with GBM who underwent gross total resection followed by adjuvan...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.23624
更新日期:2008-08-15 00:00:00