Abstract:
BACKGROUND:Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors of the nervous system. Cutaneous melanoma and nervous system tumors may independently aggregate in families. There are, however, no previous reports of increased likelihood of tumors of the nervous system in families of patients with cutaneous melanoma or--of cutaneous melanoma in families with tumors of the nervous system. METHODS:The occurrence of nervous system tumors as second cancers was examined in a series of 904 patients with cutaneous melanoma and/or their family members. RESULTS:Fifteen families with 17 members with cutaneous melanoma from this series had one or more additional relatives with tumors of the nervous system, including astrocytoma, medulloblastoma, glioblastoma multiforme, ependymoma, glioma, meningioma, and acoustic neurilemmoma. Another subgroup of 10 patients with cutaneous melanoma had either a meningioma (n = 9) or acoustic neurilemmoma (n = 1) as a second tumor. The pattern of atypical melanocytic nevi occurring in the majority (20/25) of cutaneous melanoma patients in our series and in additional first degree relatives of 9 of 11 of the affected families, has been previously associated with the Familial Atypical Multiple Mole-Melanoma syndrome. CONCLUSIONS:This unusual familial and personal occurrence of tumors, showing differentiation toward tissues of the neural crest, neuroepithelium, and/or mesenchymal derivation, supports a putative association with a hereditary cancer susceptibility trait.
journal_name
Cancerjournal_title
Cancerauthors
Azizi E,Friedman J,Pavlotsky F,Iscovich J,Bornstein A,Shafir R,Trau H,Brenner H,Nass Ddoi
10.1002/1097-0142(19951101)76:9<1571::aid-cncr2820subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1571-8issue
9eissn
0008-543Xissn
1097-0142journal_volume
76pub_type
杂志文章相关文献
CANCER文献大全abstract::A clinicopathologic study of 51 patients with endoscopically removed large bowel polyps showing histologic evidence of malignancy, either focally, to a massive extent, or comprising the entire polyp, revealed only one absolute finding capable of predicting residual disease, namely, the presence of cancer at the resect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1691::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of comm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33232
更新日期:2021-02-15 00:00:00
abstract::The woman treated for gynecologic cancer must contend with a challenging group of issues in her efforts to recover psychologically in the months and years after treatment: chance of dying, changed self-perception, treatment-related menopause, impaired or lost fertility, sexual dysfunction, and relationship problems mu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951115)76:10+<2117::aid-cncr28
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:: Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third-generation agents (gemcitabine [G], vinorelbine, ...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.24207
更新日期:2009-05-01 00:00:00
abstract::Endoscopic neodymium yttrium aluminium garnet (Nd YAG) laser therapy, is a new and simple method for the palliative treatment of inoperable colorectal cancer. To date the authors have treated 70 patients and the value of this method was assessed prospectively in 14 patients. Quality of life was measured before, during...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890301)63:5<967::aid-cncr28206
更新日期:1989-03-01 00:00:00
abstract::Combined modality therapy consisting of CHOP-Bleo (cyclophosphamide, Adriamycin [doxorubicin], vincristine (Oncovin), prednisone, and bleomycin) and limited-field radiotherapy was given to 47 patients with Stage III and IIIE diffuse large cell lymphomas. Overall 5-year survival and disease-free survival figures are 64...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840401)53:7<1478::aid-cncr2820
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. METHODS:Based on inter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1<77::aid-cncr282070
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11937
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:An increase in resting energy expenditure (REE) is considered to contribute to the weight loss experienced by patients with cancer. However, alternations in basal metabolism vary among patients with different neoplasms. REE in patients with hepatocellular carcinoma (HCC), a common malignant tumor in Taiwan, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940201)73:3<590::aid-cncr28207
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26409
更新日期:2012-03-15 00:00:00
abstract::Some of the issues being addressed in mammography quality assurance are 1) that image quality is the most important technical aspect of mammography; 2) that image quality has improved steadily over the past two decades and will continue to improve at most mammography sites in the United States; 3) that the American Co...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930815)72:4+<1466::aid-cncr282
更新日期:1993-08-15 00:00:00
abstract::A case of meningeal melanocytoma of the left Meckel's cave associated with ipsilateral Ota's nevus in a 43-year-old woman, was studied by light and electron microscopy. The cells of the tumor were characterized by the presence of dendritic cytoplasmic processes, melanosomes and premelanosomes; hence, they were deemed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12<2304::aid-cncr282
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:Recent studies revealed that incidence rates of cutaneous melanoma (CM) were leveling off predominantly among younger people and patterns suggested birth-cohort effects. The current study analyzed the development of prognostic factors and survival in incident CM over 25 years. METHODS:All 45,483 patients wi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20816
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymph node dissection is a fundamental step in the surgical management of patients with pelvic gynecologic malignancies, but its applicability to geriatric patients is controversial. The objective of this study was to evaluate whether pelvic and aortic lymphadenectomy in elderly patients with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011115)92:10<2562::aid-cncr160
更新日期:2001-11-15 00:00:00
abstract::Solitary extramedullary plasmacytomas are rare tumors, reported to occur most commonly in the upper respiratory passages, but which also are rarely seen in the middle and lower gastrointestinal system. This report documents the first primary plasmacytoma of the esophagus. A 67-year-old Caucasian man complained of dysp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<943::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:Elderly people constitute a heterogeneous group and are at an increased risk for the development of cancer. It is not clear whether comorbid conditions and functional status influence clinical decisions and the pattern of referral in elderly cancer patients. The current study investigated functional status m...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-02-15 00:00:00
abstract::Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. However, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. Receptor activator of NF-kappaB ligand (RANKL), macrophage inflammatory protein (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11133
更新日期:2003-02-01 00:00:00
abstract::This article describes the clinicopathologic features of six cases of uterine papillary serous carcinoma (UPSC), which developed several years after radiation therapy (RT) for cervical carcinoma. The possible etiologic role of radiation is discussed, and the literature on endometrial carcinomas developing after RT is ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<496::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:For the moment, there is uncertainty about the usefulness of early treatment of localized prostate carcinoma, uncertainty about whether some patients with early cancer can be managed expectantly, and uncertainty about how such patients might be recognized. METHODS:The authors studied serial values of prosta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10443
更新日期:2002-03-15 00:00:00
abstract::The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810201)47:3<452::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract::The diagnosis and grading of chondrosarcoma of bone is best established by a complementary study of its cytology, as observed in smeared preparations, and of its tissue structure and relationship to the host bone, as observed in histologic sections. Smeared preparations demonstrate the cytologic features of chondrosar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<582::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Adjustment disorders and major depression are common psychiatric disorders in patients with cancer and have a serious impact on quality of life. The problem in clinical oncology settings is underrecognition of these disorders; as a result, screening is recommended to detect them. The goal of the current stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11358
更新日期:2003-05-15 00:00:00
abstract::The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<906::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract:BACKGROUND:: Histologic parameters of melanoma deposits in sentinel lymph nodes (SLNs) have been shown to be predictive of clinical outcome and the presence or absence of tumor in non-SLNs, but assessment of these parameters is prone to interobserver variation. METHODS:: Histologic sections of 44 SLNs containing metas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24298
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Since the introduction of the TNM residual tumor (R) classification, the involvement of resection margins has been defined either as a microscopic (R1) or a macroscopic (R2) demonstration of tumor directly at the resection margin ("tumor transected"). METHODS:The recognition of the importance of the circumf...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24320
更新日期:2009-08-01 00:00:00
abstract::Fourteen new colorectal cancer cell lines were developed as part of a tumor acquisition, propagation, and preservation program for biotherapy. Fifty-six specimens were received. Nine cell lines were generated from biopsies; seven of these cell lines were from metastatic lesions. Five additional cell lines were develop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1600::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1980.45.s7.1803
更新日期:1980-04-01 00:00:00
abstract::The endocrine action of medroxyprogesterone acetate (MPA) has been claimed to be of a glucocorticoid-like nature. Upon clinical observation, MPA has been shown to improve life quality and overall well-being in patients with advanced breast cancer, renal carcinoma, prostatic carcinoma, and uterine adenocarcinoma. The a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901101)66:9<1949::aid-cncr2820
更新日期:1990-11-01 00:00:00
abstract::Twenty of 391 newly diagnosed cases of prostatic cancer (5%) had a prior prostatectomy for benign disease. Digital rectal examination in 16 of 19 patients (84%) revealed a significant prostatic abnormality. Continued serial digital rectal examination should be performed routinely after prostatectomy for benign disease...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860815)58:4<994::aid-cncr28205
更新日期:1986-08-15 00:00:00